Adenoid cystic carcinoma: triple negative breast cancer with good prognosis

Romeira, Daniel; Cardoso, Débora; Miranda, Helena; Martins, Ana

doi:10.1136/bcr-2015-213704

Cited by 9 publications

(15 citation statements)

References 16 publications

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“…There have been no large scale studies to show benefit. Therefore, based on extrapolation of evidence in other breast cancer subtypes, chemotherapy has usually been reserved for patients who are young with large tumors or extensive nodal involvement . In our case series, distant disease occurred in the pleura and in one case the liver.…”

Section: Discussionmentioning

confidence: 88%

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Is axillary surgery beneficial for patients with adenoid cystic carcinoma of the breast?

Welsh

Keeney

Hoskin

et al. 2017

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 88%

“…Adenoid cystic carcinoma (ACC) or cylindroma is an extraordinarily rare subtype of breast cancer which accounts for fewer than 0.1% of all breast cancer diagnoses . It most frequently presents in post‐menopausal women with mean age of 50‐60 years.…”

Section: Introductionmentioning

confidence: 99%

Is axillary surgery beneficial for patients with adenoid cystic carcinoma of the breast?

Welsh

Keeney

Hoskin

et al. 2017

Journal of Surgical Oncology

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“…[20] According to the percentage of the tumor that is solid, it can be divided into 3 grades. [21] Tumors with a higher percentage of solid mass always have more aggressive biological behavior. [12] The diagnosis of breast ACC in the frozen section is challenging because of histological complexity.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of axillary lymph node metastasis was less than 2% in previous reports. [21,22] Distant metastasis mostly occurred in the lung without lymph node infiltration. [20] Previous studies reported 5-year and 10-year overall survival rates of more than 95% and 90%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma of the breast in a male

Pang

Wang²,

Jin³

et al. 2019

Medicine

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Rationale: Adenoid cystic carcinoma (ACC) of the breast is an infrequent neoplasm, and the occurrence in males is rare. Therefore, diagnostic and therapeutic challenges are inevitable. Patient concerns: Herein, we present a case of a 44-year-old man with a tumor on his right breast that he had known about for 6 years. Diagnoses: The patient underwent a lumpectomy, and the histological examination confirmed a diagnosis of ACC. Interventions: Modified radical mastectomy was subsequently conducted in the patient. No positive lymph nodes were observed in the postoperative pathological examination. Following the surgery, the patient received adjuvant chemotherapy. Outcomes: The patient remained recurrence-free at 26 months. Lessons: Compared to female breast ACC, male breast ACC may behave differently biologically and have a different prognosis. Our case will provide more diagnostic and treatment experience to deal with this disease.

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“…Mean LRFS reported by case reports was 24 months (range 20-48) [3,4,8,[10][11][12]. Mean DFS reported by case series and retrospective series was 87.9% (range 69-100%) [2,5,[13][14][15][16]. Mean OS reported in case reports was 30 months (range 12-84) [3,4,8,[10][11][12].…”

Section: Resultsmentioning

confidence: 99%

The role of radiotherapy (RT) in the treatment of Adenoid Cystic Carcinoma of the Breast: case report of RT retreatment and literature review

Smaniotto¹,

Terribile²,

Marazzi³

et al. 2019

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This study reviews the recent literature on the role of definitive radiotherapy (RT) in the management of adenoid cystic carcinoma of the breast (ACCB) and presents comprehensive data on clinical outcomes. A case report of radiotherapy retreatment in ACCB is reported for first time in literature. Methods: The authors performed a literature review using PubMed (1981-2019) to identify all studies that match with keywords. Inclusion criteria were articles reporting patients underwent radiotherapy after ACCB diagnosis with follow up reporting. Data analyzed were number of pts, age, study design, multimodality treatment management with radiotherapy schedule, stage of disease, pathological risk factors, local relapse free survival (LFRS), metastases free survival (MFS) and overall survival (OS). Results: Of the 60 identified studies, 15 met the inclusion criteria. All studies had a retrospective design. Overall, 967 patients (median, 64; range, 1-478) were included. A high heterogeneity was found across studies in terms of pathological features available, local approach in multimodality management, adjuvant RT administration, and reported outcomes. Mean LRFS reported by case reports was 24 months (range 20-48). Mean DFS reported by case series and retrospective series was 87.9% (range 69-100%). Mean OS reported in case reports was 30 months (range 12-84). Mean 5-years OS reported in retrospective series was 89.7%. Mean 10-years OS reported in retrospective series was 78.7%. In some retrospective series radiotherapy was found significantly related to local control (p=0.03) and with an absolute survival benefit of 9% at 5 year and of 21% at 10 years (p=0.005). Conclusion and implications for practice: To our knowledge this is the first report on radiotherapy retreatment in ACCB local relapse. This study also reviews the recent literature on the role of adjuvant RT in the management of ACCB and presents comprehensive data on long-term clinical outcome. Some significant results about RT are improvement in local control and survival benefit also since at 10 years in some series. Further studies are needed to confirm these results.

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Adenoid cystic carcinoma: triple negative breast cancer with good prognosis

Cited by 9 publications

References 16 publications

Is axillary surgery beneficial for patients with adenoid cystic carcinoma of the breast?

Is axillary surgery beneficial for patients with adenoid cystic carcinoma of the breast?

Adenoid cystic carcinoma of the breast in a male

The role of radiotherapy (RT) in the treatment of Adenoid Cystic Carcinoma of the Breast: case report of RT retreatment and literature review

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