Adenoid cystic salivary gland carcinoma: A clinicopathologic correlation

Matsuba, Howard M.; Simpson, Joseph R.; Mauney, Marc; Thawley, Stanley E.

doi:10.1002/hed.2890080312

Cited by 61 publications

(33 citation statements)

References 16 publications

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“…Several previous studies showed that advanced stage, high grade, and submandibular location were prognostic for a poorer outcome, and differences in histological features were reported to affect natural history [8,23,25,26,27,28,29]. Positive/close margins on histopathology and cT4 stage for VII nerve involvement or for involvement of other structures were the only clinical parameters at diagnosis retaining their value also at multivariate analysis (Fig.…”

Section: Discussionmentioning

confidence: 86%

Clinical History, Prognostic Factors, and Management of Facial Nerve in Malignant Tumors of the Parotid Gland

Bussu

Rigante

Giglia

et al. 2014

Clin Exp Otorhinolaryngol

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ObjectivesWe analyzed the outcomes following clinical management of parotid masses that were determined to be malignant tumors after parotidectomy.MethodsWe evaluated data from 70 patients with parotid malignancies between November 1994 and December 2005.ResultsAmong salivary histotypes (n=49), the most significant prognostic parameter was cT4 stage at diagnosis (P=0.0055, log-rank) both for clinical involvement of the facial nerve and for invasion of other structures. The main cause of cancer-related death was a distant metastasis.ConclusionThe present series confirms that the main prognostic parameter in salivary parotid malignancies was cT4 classification at diagnosis, often due to clinical involvement of the facial nerve. The oncological outcome of salivary malignancies was influenced by distant metastasis more than most other head and neck sites. We recommend dissecting and preserving the functioning VIIth cranial nerve during surgery for parotid malignancies.

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Section: Discussionmentioning

confidence: 86%

Clinical History, Prognostic Factors, and Management of Facial Nerve in Malignant Tumors of the Parotid Gland

Bussu

Rigante

Giglia

et al. 2014

Clin Exp Otorhinolaryngol

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“…Though most cases arise in head and neck, other primary locations include breast, lung, larynx, and trachea [15]. Adenoid cystic carcinoma can invade into the neighboring structures/organs by direct extension and perineural invasion and lead to distant metastases via hematogeneous route [16,17]. Adenoid cystic carcinoma arising in the laryngo-tracheal tree can invade into the thyroid gland and clinically present as a thyroid nodule [15,18].…”

Section: Discussionmentioning

confidence: 99%

Unique Growth Pattern in Papillary Carcinoma of the Thyroid Gland Mimicking Adenoid Cystic Carcinoma

2011

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We report here three cases of papillary thyroid carcinoma (PTC) with hyaline globules as seen in adenoid cystic carcinoma of the salivary glands. This unique growth pattern was seen in two cases of columnar cell and one case of cribriform morular variant of PTC. Fine-needle aspiration was performed in two cases. By immunohistochemistry, all cases demonstrated expression of TTF-1 and thyroglobulin confirming follicular cell derivation. It is important to be aware of this unusual growth pattern in thyroid carcinomas; immunohistochemistry is warranted for rendering accurate cytopathologic and histopathologic diagnosis.

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“…Adenoid cystic carcinoma occurs primarily in the major and minor salivary glands, but can also be found at other sites 2 . The disease usually presents in a localized manner, but is known for its propensity for late metastasis (up to 15 years after initial diagnosis) 3 . Although acc can be found at any age, it typically presents in the 5th decade (median age: 57.4 years), and it has a slight female preponderance (up to 60% of cases) 2 .…”

Section: Introductionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of Head and Neck: Clinical Predictors of Outcome from a Canadian Centre

Siever

Hao

et al. 2016

Current Oncology

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Objectives Adenoid cystic carcinoma (acc) is often treated with surgery, with or without adjuvant radiation therapy (rt). We evaluated disease characteristics, treatments, and potentially prognostic variables in patients with acc.Methods Our retrospective analysis considered consecutive cases of acc presenting at a tertiary care hospital between 2000 and 2014. Factors predictive of overall survival (os) and disease-free survival (dfs) were identified by univariate analysis. ResultsThe 60 patients analyzed had a mean age of 58 years (range: 22-88 years), with a 2:1 female:male ratio. Tumour locations included the major salivary glands (40% parotid, 17% submandibular and sublingual), the oro-nasopharyngeal cavity (27%), and other locations (16%). Of the 60 patients, 35 (58%) received surgery with adjuvant rt; 12 (20%), rt only; 13 (22%), surgery only. Of 18 patients (30%) who experienced a recurrence within 5 years, 3 (5%) developed local recurrence only, and the remaining 15 (25%), distant metastasis. The 5-year os and dfs were 64.5% [95% confidence interval (ci): 45.9% to 78.1%] and 46.2% (95% ci: 29.7% to 61.2%) respectively. In patients without recurrence, 5-year os was 77% (95% ci: 52.8% to 89.9%), and in patients with recurrence, it was 42.7% (95% ci: 15.8% to 67.6%). Patients treated with rt only had a 5-year os of 9.2%. Predictors of 5-year dfs were TNM stage, T stage, nodal status, treatment received, and margin status; age, nodal status, treatment received, and margin status predicted 5-year os.Conclusions Despite surgery and rt, one third of patients with acc experience distant recurrence. Patients whose tumours are not amenable to surgery have a poor prognosis, indicating a need for alternative approaches to improve outcomes.

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Adenoid cystic salivary gland carcinoma: A clinicopathologic correlation

Cited by 61 publications

References 16 publications

Clinical History, Prognostic Factors, and Management of Facial Nerve in Malignant Tumors of the Parotid Gland

Clinical History, Prognostic Factors, and Management of Facial Nerve in Malignant Tumors of the Parotid Gland

Unique Growth Pattern in Papillary Carcinoma of the Thyroid Gland Mimicking Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma of Head and Neck: Clinical Predictors of Outcome from a Canadian Centre

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