Adenoid squamous cell carcinoma of upper lip, a rare variant of squamous cell carcinoma: A case report

Bhogavaram, Bharadwaj; Sinha, Ramen; Rapolu, Keerthi; Boggarapu, Bhanu Praseedha

doi:10.4103/jfmpc.jfmpc_850_20

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…While angiosarcoma shares few similarities with ASCC histologically, the clinical and immunostaining profile aids to demarcate between the two lesions (CD31, CD34, Fli-1 protein are highly specific markers of angiosarcoma). 4,8 The present case had to be differentiated from ASC and the conventional SCC. Employing the special stains helped to rule out ASC and presence of acantholytic cells and ductlike areas rules out the latter.…”

Section: Discussionmentioning

confidence: 92%

“…However, due to less number of cases and studies on intra-oral ASCCs, no definitive etiology has been described yet. 8 The loss of cellular adhesion in ASCC is attributed to the desmosomal defects especially desmoglein 1,2 or desmoplakin or both are affected. 9 Around 50 cases of ASCC affecting the oral cavity have been reported till now with lower lip being the most affected site and with more male predilection.…”

Section: Discussionmentioning

confidence: 99%

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Adenoid (Acantholytic) squamous cell carcinoma of the alveolar ridge: A rare case report

Kulkarni

Sahana²,

T³

et al. 2022

JOOO

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Adenoid squamous cell carcinoma (ASCC) is a one of the histological variants of oral squamous cell carcinoma with a rare occurrence of less than 4% of all the cases. The tumour has a slight male predilection with lower lip being the most affected site. ASCC is said to have a varied biologic behaviour which accounts for its ability to metastasize to distant sites and hence has poor prognosis. The histopathology shows numerous duct-like structures with central acantholytic cells. Distinct cytological atypia is seen which aids in diagnosis of SCC. Special stains help in differentiating the tumour from other variants of SCC. The presented case of a 70-year-old female emphasizes the importance of histopathogical examination of the unusual and rarely observed ASCC which can be missed due to similarities with other entities. Recurrence rates being very high, proper treatment starting with definitive diagnosis is imperative.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Adenoid (Acantholytic) squamous cell carcinoma of the alveolar ridge: A rare case report

Kulkarni

Sahana²,

T³

et al. 2022

JOOO

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“…No definitive etiology has been identified because of the scarcity of cases and investigations on intra-oral ASCCs. However, several distinct mechanisms, such as Bhogavaram et al 43 have highlighted trauma as a factor. According to O'Shea et al, 12 the lack of cellular adhesion in ASCC is caused mostly by desmosomal abnormalities, specifically desmogleins 1 and 2, desmoplakin, or both.…”

Section: Discussionmentioning

confidence: 99%

Acantholytic oral squamous cell carcinoma with clear cell change - a rare amalgamated variant

Sharma,

Devi,

Kamboj

et al. 2023

Autops Case Rep

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Background Acantholytic squamous cell carcinoma (ASCC) is an uncommon histological variation of oral squamous cell carcinoma (OSCC), accounting for fewer than 4% of all occurrences. The tumor shows a slight masculine predisposition, with the lower lip being the most commonly affected location. ASCC is reported to have a diverse biologic behavior, which explains its ability to metastasize to distant places and, thus, its poor prognosis. Similarly, clear cell change in OSCC is a rare occurrence with an unknown etiology that suggests its aggressive nature. Method and Results Histopathology reveals central acantholytic cells with numerous duct-like features. The presence of distinct cytological atypia contributes to the diagnosis of SCC. Special stains and IHC aid in distinguishing tumor from other histopathologically similar entities. Conclusion The case of a 29-year-old male presented here with an updated literature review highlights the need for histological study of the unique and seldom seen oral ASCC with clear cell change, which can be ignored because of similarities with other entities. Because recurrence rates are so high for ASCC, amalgamated clear cell change makes it critical for proper treatment initiation with a definite diagnosis. To the best of our knowledge, this is the first documented occurrence. Our experience with the present case suspected a more aggressive behavior due to a high Ki-67 index, anticipating a poorer prognosis in the oral cavity considering the patient's young age.

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Adenoid (Acantholytic) Squamous Cell Carcinoma of Mandibular Gingiva

Raut

Keshwar

Jaisani

et al. 2021

Case Reports in Dentistry

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Introduction. Adenoid (acantholytic) squamous cell carcinoma (ASCC) is a histological variant of squamous cell carcinoma which occurs mainly in the sun-exposed areas of the head and neck region. It is commonly seen among males which mainly occurs in the sixth and seventh decade of life with lip being predominately affected. Limited scientific literature is documenting the intraoral presentation of ASCC in contrast to its usual extraoral lesions associated with the skin. Characteristic pseudo glandular alveolar space formation seen in ASCC often mimics carcinoma of salivary gland origin. In-depth knowledge of histopathological features of ASCC is important to diagnose this uncommon variant. Case Description. An 80-year-old female presented with the chief complaint of the nonhealing lesion in the right lower back region of the jaw for 2 months, associated with pain. A provisional diagnosis of oral cancer was considered, and an incisional biopsy was done. Histopathological presentation of the epithelial tumor island, pseudo glandular duct-like structures, and neoplastic cells showing features of dysplasia and keratin pearl formation confirmed the diagnosis as adenoid (acantholytic) squamous cell carcinoma. Conclusion. The histopathological presentation of adenoid (acantholytic) squamous cell carcinoma reflects the prognosis and metastatic behavior of the diseases. The knowledge of histopathological features of ASCC would be a guide to the untrained eye for the diagnosis and management of this uncommon variant to minimize the rate of metastasis or reoccurrence.

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Adenoid squamous cell carcinoma of upper lip, a rare variant of squamous cell carcinoma: A case report

Cited by 3 publications

References 7 publications

Adenoid (Acantholytic) squamous cell carcinoma of the alveolar ridge: A rare case report

Adenoid (Acantholytic) squamous cell carcinoma of the alveolar ridge: A rare case report

Acantholytic oral squamous cell carcinoma with clear cell change - a rare amalgamated variant

Adenoid (Acantholytic) Squamous Cell Carcinoma of Mandibular Gingiva

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