Adenoma detection rate metrics in colorectal cancer surveillance colonoscopy

Tjaden, Jamie M.; Hause, Jessica; Berger, Daniel; Duveneck, Samantha K.; Jakate, Shriram; Orkin, Bruce A.; Hubbard, Elizabeth; Melson, Joshua

doi:10.1007/s00464-018-6025-3

Cited by 16 publications

(10 citation statements)

References 20 publications

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“…[ 14 ] Secondary surveillance ADR after colorectal resection for colon cancer was significantly higher than first surveillance ADR colorectal resection for colon cancer. [ 15 ] Moreover, Fuccio et al reported an ADR of 25.2% on second surveillance colonoscopy with a higher rate in those who had left hemicolectomy than right hemicolectomy. [ 9 ] Furthermore, Yun et al also showed that left colon resection had a higher incidence of adenoma than right colon resection in the second surveillance colonoscopy.…”

Section: Discussionmentioning

confidence: 99%

The incidence and risk factors of sessile serrated adenomas in left side colon cancer patients after curative surgery

et al. 2020

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Sessile serrated adenomas (SSAs) are precursors of colorectal cancer (CRC). However, there are limited data on detection rates of this premalignant lesion during colonoscopy surveillance in patients with a history of left side colonic resection for cancer. We aimed to identify the incidence and risk factors of SSAs in post-left side colectomy patients. We retrospectively reviewed the medical records of patients who had undergone left side colectomy for colon and rectal cancer between September 2009 and September 2016 and had at least 1 follow-up colonoscopy. Patient baseline characteristics, SSA diagnoses and characteristics, and colonoscopy information were collected. In total, 539 patients were enrolled. At the first follow-up (mean duration 11.5 months), 98 SSAs were identified (22.2%). At the second follow-up (mean duration 25.8 months), 51 SSAs were identified in 212 patients (24.0%). Multivariate analysis showed that alcohol intake (hazard ratio [HR] 1.524; 95% confidence interval [CI] .963–2.411, P = .041), excellent bowel preparation (HR 2.081; 95% CI 1.214–3.567, P = .049), and use of a transparent cap (HR 1.702; 95% CI 1.060–2.735, P = .013) were associated with higher SSA incidence in the first surveillance colonoscopy, while body mass index (BMI) ≥ 25.0 (HR 1.602; 95% CI 1.060–2.836) was associated with a significantly increased risk of SSAs in the second surveillance. Considering the endoscopic appearance of SSAs, adequate bowel preparation and use of transparent caps during postoperative surveillance colonoscopy can increase the diagnosis rate. Modification of alcohol intake and BMI may reduce the incidence of SSAs in left side colon cancer patients.

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Section: Discussionmentioning

confidence: 99%

The incidence and risk factors of sessile serrated adenomas in left side colon cancer patients after curative surgery

et al. 2020

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“…High-quality colonoscopy requires rigorous standards of quality control [6]. The three most commonly recommended colonoscopy key performance indicators (KPIs) are the caecal intubation rate (CIR) [6][7][8], the adenoma detection rate (ADR) [9,10] and the colonoscope withdrawal time (CWT) [6], although the specific KPI calculations and targets vary between different clinical practice guidelines [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Several large population-based studies have evaluated these KPIs for colonoscopy [9,[14][15][16][17][18][19][20][21][22][23]. Some studies included all patients undergoing colonoscopy [14][15][16]18]; however, others elected to exclude patients who have previously had a colonic resection (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies included all patients undergoing colonoscopy [14][15][16]18]; however, others elected to exclude patients who have previously had a colonic resection (i.e. patients with nonintact colons) from calculations of CIR, ADR, CWT and other KPIs [9,17,[19][20][21][22][23]. Despite none of the current guidelines specifically recommending this practice, it appears to be based on the assumption that it is easier to reach the caecum in a patient with a nonintact colon and therefore inclusion of these patients may make it easier for the endoscopist to meet KPI targets.…”

Section: Introductionmentioning

confidence: 99%

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Colonoscopy quality indicators in patients with and without prior colonic resection: A single‐centre prospective comparative study

et al. 2021

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“…Although several organizations have issued guidelines on individuals or population-based CRC screening and the efforts have contributed more or less to the declined morbidity and mortality of CRC 11 - 14 , the increased annual CRC incidences worldwide highlight the need of developing more effective approaches. On the other hand, currently used screening methods either have uncertain or limited efficiency (e.g., stool-based tests) or are acceptable by few people without symptoms as routine test due to invasiveness, complicate processes and high cost (e.g., colonoscopy) despite its reliable for detection 12 , 15 - 17 . Thus, discovery and development of more reliable and feasible biomarkers, which enable the identification of individuals at high risk or with early CRC who should further undergo colonoscopy, are in urgent need.…”

Section: Introductionmentioning

confidence: 99%

Serum piRNA-54265 is a New Biomarker for early detection and clinical surveillance of Human Colorectal Cancer

et al. 2020

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Background: Our previous study has demonstrated an oncogenic role of PIWI-interacting RNA-54265 (piR-54265) in colorectal cancer (CRC). Here, we investigate whether it can be a blood biomarker for population screening and clinical applications. Methods: Serum piR-54265 levels were determined by a digital PCR method in 209 cancer-free healthy controls, 725 patients with CRC, 1303 patients with other types of digestive cancer and 192 patients with benign colorectal tumors. A prospective case-control analysis was conducted to assess the predictive value of serum piR-54265 for future CRC diagnosis. Receiver operating characteristic (ROC) curve was constructed to quantify the diagnostic performance of serum piR-54265 levels by assessing its sensitivity, specificity and respective areas under curve (AUC). The odds ratios (ORs) were computed using multivariate logistic regression models. Results: Serum piR-54265 levels were significantly elevated only in patients with CRC compared with controls and patients with other cancer types. The AUC for recognizing CRC was 0.896 (95% CI, 0.874-0.914), with a sensitivity and specificity being 85.7% and 65.1% at 1500 copies/µL as a cut-off value. The serum piR-54265 levels in patients declined substantially after surgery but increased significantly again when tumor relapses. The prediagnostic serum piR-54265 levels were significantly associated with future CRC diagnosis, with the ORs of 7.23, 2.80, 2.45, and 1.24 for those whose CRC was diagnosed within 1, 2, 3 and >3 years. Serum piR-54265 test is more sensitive than other blood CRC markers. Conclusion: Serum piR-54265 may serve as a valuable biomarker for CRC screening, early detection and clinical surveillance.

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Adenoma detection rate metrics in colorectal cancer surveillance colonoscopy

Cited by 16 publications

References 20 publications

The incidence and risk factors of sessile serrated adenomas in left side colon cancer patients after curative surgery

The incidence and risk factors of sessile serrated adenomas in left side colon cancer patients after curative surgery

Colonoscopy quality indicators in patients with and without prior colonic resection: A single‐centre prospective comparative study

Serum piRNA-54265 is a New Biomarker for early detection and clinical surveillance of Human Colorectal Cancer

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