Adenoma malignum of the uterine cervix: ultrasonographic findings in 11 patients

Park, S. B.; Moon, Min Hoan; Hong, Sungchul; Lee, M. S.; Cho, H. C.; Han, Byoung Hee; Lim, Kyung-Taek

doi:10.1002/uog.9078

Cited by 28 publications

(24 citation statements)

References 19 publications

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“…With large-scale HPV vaccination programs and the projected decrease in the prevalence of HPV-associated adenocarcinomas, there is potential increase in the proportion of gastric type endocervical adenocarcinomas, making early and accurate recognition even more important. Unlike HPV-associated endocervical adenocarcinomas of usual type, gastric type adenocarcinomas, including minimal deviation type, are frequently centered in the upper endocervix, 38 present with a bulky cervix, 39 are usually p16-negative or focal, demonstrate gastric differentiation, and may contain lobular endocervical glandular hyperplasia, its putative precursor. 9,16,23,40–43 We presented a more extensive description of the morphologic spectrum of these tumors in abstract form recently (manuscript in preparation) 44 ; we hope this helps pathologists better recognize these distinct tumors.…”

Section: Discussionmentioning

confidence: 99%

Gastric-type Endocervical Adenocarcinoma

Karamurzin

Kiyokawa

Parkash

et al. 2015

American Journal of Surgical Pathology

222

119

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Gastric type adenocarcinoma of the uterine cervix (GAS) is a rare variant of mucinous endocervical adenocarcinoma not etiologically associated with human papillomavirus (HPV) infection, with minimal deviation adenocarcinoma (MDA) at the well-differentiated end of the morphologic spectrum. These tumors are reported to have worse prognosis than usual HPV-associated endocervical adenocarcinoma (UEA). A retrospective review of GAS was performed from the pathology databases of three institutions spanning 20 years. Stage, metastatic patterns, and overall survival were documented. Forty GAS cases were identified, with clinical follow-up data available for 38. The tumors were subclassified as MDA (n=13) and non-MDA GAS (n=27). Two patients were syndromic (one Li-Fraumeni, one Peutz-Jeghers). At presentation, 59% were advanced stage (FIGO II–IV), 50% had lymph node metastases, 35% had ovarian involvement, 20% had abdominal disease, 39% had at least one site of metastasis at the time of initial surgery, and 12% of patients experienced distant recurrence. The metastatic sites included lymph nodes, adnexa, omentum, bowel, peritoneum, diaphragm, abdominal wall, bladder, vagina, appendix, and brain. Follow-up ranged from 1.4 to 136.0 months (mean, 33.9 months); 20/38 (52.6%) had no evidence of disease, 3/38 (7.9%) were alive with disease, and 15/38 (39.5%) died of disease. Disease specific survival at 5 years was 42% for GAS vs. 91% for UEA. There were no survival differences between MDA and non-MDA GAS. GAS represents a distinct, biologically aggressive type of endocervical adenocarcinoma. The majority of patients present at advanced stage and pelvic, abdominal, and distant metastases are not uncommon.

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Section: Discussionmentioning

confidence: 99%

Gastric-type Endocervical Adenocarcinoma

Karamurzin

Kiyokawa

Parkash

et al. 2015

American Journal of Surgical Pathology

222

119

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“…3 In one case series, ultrasound was able to identify an adenoma malignum in 9 of 11 patients who were later confirmed to have this tumour. 8 Additional features of adenoma malignum in this series included enlargement of the cervix and smooth margins to the cervical mass. A second case series described 13 cases of adenoma malignum and their associated imaging findings.…”

Section: Discussionmentioning

confidence: 71%

“…[2][3][4][5][6] This tumour has also been associated with Peutz-Jeghers syndrome (hereditary intestinal polyposis). [7][8][9] To our knowledge, adenoma malignum presenting with severe electrolyte disturbances has not been previously reported. We describe here the case of a woman with adenoma malignum who presented with profound hyponatremia and hyperkalemia, and we describe the subsequent surgical management.…”

Section: Introductionmentioning

confidence: 87%

Adenoma Malignum Presenting With Profound Hyponatremia

Mills

Shuen

Zolis

2015

Journal of Obstetrics and Gynaecology Canada

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“…Park et al . [11] reported that ultrasound imaging with Doppler examination is more efficient and accurate in the evaluation of multilocular lesions of the uterine cervix, and in their study Doppler examination revealed that AM had an increased intralesional vascularity. Recently, magnetic resonance imaging has been shown to be useful for the diagnosis of AM.…”

Section: Discussionmentioning

confidence: 99%

Adenoma malignum of the uterine cervix: report of four cases

Byun

Park

et al. 2013

World J Surg Onc

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Adenoma malignum (AM) of the cervix is a rare disease and it is difficult to diagnose due to the deceptively benign appearance of the tumor cells. These lesions have mucin-rich cystic lesions and are usually situated deep in the cervix. Since AM is very rare, standard screening tests, diagnostic tools and treatments have not yet been established. Radiologically, it mimics multiple nabothian cysts as a benign-looking tumor. Histologically, AM is a well-differentiated adenocarcinoma and could be misdiagnosed as a benign lesion. These findings make a preoperative diagnosis of AM difficult and can result in surgery being performed based on a misdiagnosis. We report here on four cases of pathologically confirmed AM.

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Adenoma malignum of the uterine cervix: ultrasonographic findings in 11 patients

Abstract: Objective

Cited by 28 publications

References 19 publications

Gastric-type Endocervical Adenocarcinoma

Gastric-type Endocervical Adenocarcinoma

Adenoma Malignum Presenting With Profound Hyponatremia

Adenoma malignum of the uterine cervix: report of four cases

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