Adenomas detected during screening colonoscopies in the years 2000-2009

Świątkowski, Maciej; Meder, Agnieszka; Sobczyński, Lesław; Koza, Jarosław; Szamocka, Małgorzata; Brudny, Janina; Korenkiewicz, Jadwiga

doi:10.5114/pg.2012.32069

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…Colorectal cancer arises from the lesions known as adenomatous polyps, commonly called adenomas. Although every adenoma has the capacity of malignant transformation very few adenomas develop into cancer [10]. A survey comparing adenoma prevalence and carcinoma incidence demonstrated that the percentage of transformation is about 0.25% per year [11].…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical assessment of mitochondrial superoxide dismutase (MnSOD) in colorectal premalignant and malignant lesions

Piecuch¹,

Brzozowa-Zasada²,

Dziewit³

et al. 2016

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IntroductionIt is generally accepted that mitochondria are a primary source of intracellular reactive oxygen species (ROS). Under physiological circumstances they are permanently formed as by-products of aerobic metabolism in the mitochondria. To counter the harmful effect of ROS, cells possess an antioxidant defence system to detoxify ROS and avert them from accumulation at high concentrations. Mitochondria-located manganese superoxide dismutase (MnSOD, SOD2) successfully converts superoxide to the less reactive hydrogen peroxide (H2O2). To the best of our knowledge, there are no available data regarding immunohistochemical expression of MnSOD in colorectal neoplastic tissues.AimTo investigate the immunohistochemical expression status of MnSOD in colorectal premalignant and malignant lesions.Material and methodsThis study was performed on resected specimens obtained from 126 patients who had undergone surgical resection for primary sporadic colorectal cancer, and from 114 patients who had undergone colonoscopy at the Municipal Hospital in Jaworzno (Poland). Paraffin-embedded, 4-µm-thick tissue sections were stained for rabbit polyclonal anti SOD2 antibody obtained from GeneTex (clone TF9-10-H10 from America Diagnostica).ResultsResults of our study demonstrated that the development of colorectal cancer is connected with increased expression of MnSOD both in adenoma and adenocarcinoma stages. Samples of adenocarcinoma with G2 and G3 grade showed significantly higher levels of immunohistochemical expression of this antioxidant enzyme. Moreover, patients with the presence of lymphovascular invasion and higher degree of regional lymph node status have been also characterised by higher levels of MnSOD expression. The samples of adenoma have been characterised by higher levels of MnSOD expression in comparison to normal mucosa as well. Interestingly, there was no significant correlation between expression and histological type of adenoma.ConclusionsDevelopment of colorectal cancer is connected with increased expression of MnSOD both in adenoma and adenocarcinoma stages.

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Section: Introductionmentioning

confidence: 99%

Immunohistochemical assessment of mitochondrial superoxide dismutase (MnSOD) in colorectal premalignant and malignant lesions

Piecuch¹,

Brzozowa-Zasada²,

Dziewit³

et al. 2016

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“…The analysis of the CRC incidence register indicates that between 2001 and 2008 in the Kujawsko-Pomorskie region the number of CRC cases increased every year and that each year there were more and more men than women registered as having been diagnosed with CRC [ 26 , 27 ]. Another paper indicates that traditional adenomas, being the most frequent pre-cancer conditions in the large intestine, occurred more frequently in men than in women, with a statistically significant difference [ 28 ]. That analysis suggests that men ought to be encouraged to attend screenings as they, either at their doctor's prompting or spontaneously, come forward for screening tests less frequently than women [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Serrated polyps detected during screening colonoscopies

Świątkowski¹,

Meder²,

Sobczyński³

et al. 2014

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Aim of the studyIt is estimated that between 15% and 35% of sporadic colorectal cancers (CRC) developing from adenomas come from serrated polyps. Currently, the most effective method used to prevent CRC is the removal of adenomas, including serrated polyps, during colonoscopy. The aim of this paper is to analyze the changes characterized as serrated polyps and detected during screening colonoscopies performed as part of the Screening Program for Early Colorectal Cancer Detection (SPED).Material and methodsIn our center, as part of the nationwide SPED between 2000 and 2009, 1,442 screening colonoscopies were performed.ResultsSerrated polyps were found in 11.9% of all patients and in 45.8% of patients who had polyps removed by endoscopy. In screening colonoscopy of the large intestine, the following polyps were found most frequently: hyperplastic, < 1 cm, without a stalk, multiple, located in the distal part of the large intestine, in men and in patients with a first-degree relative with a history of abdominal cancer. Detecting and removing polyps was facilitated by the fact that the cecum was intubated and the bowel preparation had been performed either very well or well. The detection rate of serrated polyps was not influenced by patients’ place of residence or their age.ConclusionsSerrated polyps constitute a frequent, and very frequent among removed polyps, abnormality detected during screening colonoscopy.

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“…There are in Poland screening programs in many cases realised with very good effects e.g. concerning the cancer of the liver [ 7 ] or colorectal cancer [ 8 , 9 ]. The greater emphasis should be put on prevention, prophylaxis and detection of diseases in the earliest stages.…”

Section: The Main Issuementioning

confidence: 99%

Multiple endocrine neoplasia and primary hyperparathyroidism – practical approach

Koza

2015

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Adenomas detected during screening colonoscopies in the years 2000-2009

Cited by 4 publications

References 12 publications

Immunohistochemical assessment of mitochondrial superoxide dismutase (MnSOD) in colorectal premalignant and malignant lesions

Immunohistochemical assessment of mitochondrial superoxide dismutase (MnSOD) in colorectal premalignant and malignant lesions

Serrated polyps detected during screening colonoscopies

Multiple endocrine neoplasia and primary hyperparathyroidism – practical approach

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