Adenomatoid odontogenic tumor: An updated analysis of the cases reported in the literature

Background Adenomatoid odontogenic tumor constitutes an uncommon benign odontogenic tumor which is well-known as “two-thirds tumor” (two-thirds of adenomatoid tumors occur in the maxilla, two-thirds occur in young females, two-thirds of the cases are associated with un-erupted teeth and two-thirds of the affected teeth are canines). Larger part of these present as intra - osseous tumors while peripheral counterparts are extremely rare. Peripheral adenomatoid odontogenic tumor is a unique entity which generally presents as a slow growing gingival swelling with minimal bone involvement. This often leads to its erroneous diagnosis as a simple gingival lesion and the real diagnosis is only revealed after its microscopic evaluation. It exhibits a marked predilection for maxillary gingiva of incisor region and most commonly affects the younger females. Case presentation We report a case of 25 years old female patient of African ethnicity who presented with a 2 × 2 cm mass attached to the left mandibular gingiva in cuspid- bicuspid region which is an unusual site for AOT. It was accompanied by slight bone loss. With the differential diagnosis of gingival epulis and peripheral ossifying fibroma; surgical excision was performed. The light microscopic examination of the specimen aided the final diagnosis of Adenomatoid odontogenic tumor with the histopathological features identical to its intra osseous counterpart. Conclusion In this case, the tumor is present on the mandibular gingiva in a 25 years old patient which is an atypical location and age for this tumor; also, the only individual case reported in an African patient. Only, a meager number of peripheral adenomatoid odontogenic tumor cases have been logged so far with majority of them occurring in maxillary gingiva. Furthermore, an ambiguity still prevails regarding its true origin and possible biological course. Hence, reporting of similar cases should be encouraged to facilitate the better understanding of its varied epidemiological details and clinical presentation.

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“…Similar clinical findings were reported by Chrcanovic BR and Gomez RS in 2019 who analyzed the data available on all the variants of AOT [ 27 ].…”

Section: Discussionsupporting

confidence: 86%

Peripheral adenomatoid odontogenic tumor in a cloak of an epulis: report of a rare case

et al. 2019

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“…In the European-American literature, controversy surrounds concerning the 1971 report of Fukaya et al 2 describing a recurrent AOT, because a Japanese-language paper on the primary lesion published in 1960 by Mabuchi and Usizima 3 is not available in Western countries. 1 For investigators whose first language is not Japanese, we illustrate here that Fukaya et al 2 made clear reference to recurrence of an AOT (Figure 1…”

Section: Dear Editormentioning

confidence: 68%

“…We were impressed with the meticulous attention to detail regarding the recurrence of adenomatoid odontogenic tumor (AOT) in the recent article by Chrcanovic and Gomez. 1 It was a pleasure to learn that they had taken an interest in our report on AOT recurrence (see Supporting Information). 1 This letter focuses on the unanswered questions relating to two cases of recurrent AOT published in Japanese to which Chrcanovic and Gomez 1 referred.…”

Section: Dear Editormentioning

confidence: 99%

Recurrence of adenomatoid odontogenic tumor

Ide

Matsumoto

Miyazaki

et al. 2018

J Oral Pathology Medicine

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In 1988, an AOT that was noteworthy for multiple recurrences and cranial extension was documented by Japanese neurosurgeons Takigami et al (see Supporting Information). 1 This perplexing lesion has been a source of debate in the AOT literature. To help understand its true nature, we retrieved two clinical abstracts provided by the referring oral surgeons at the same institution. 4,5 One abstract summarized that a 39-year-old woman was seen in 1976 complaining of a non-healing maxillary second molar extraction site. 4 A 3-cm cystic tumor occurred without associated tooth involvement, and a painful facial swelling was a clinical sign of the first recurrence. 4 These descriptions are not typical of AOT. 1 Additional information comes from another abstract that tabulated five cases of AOT including this debatable lesion. 5 In most examples, the patient age distribution (mean 44.6 years [range 30-67]), the tumor locations (three in the posterior maxilla), and the radiographic findings (two appearing to be multilocular, all lacking radiopaque foci, and four showing no relationship to a tooth) were not consistent with AOT. 1 These features imply that the so-called adenoid cystic spaces of ameloblastomas are likely to have been confused with duct-like structures of AOT by general medical pathologists who had little knowledge about the clinical and radiological properties of odontogenic tumors. A case described by Takigami et al provides a good example of this diagnostic pitfall. In summary, with the exception of several problematic reports (see Supporting Information), only two acceptable examples of AOT recurrence exist among the 1558 cases on record. 1 It seems logical that AOT is a hamartoma, even though a follicular lesion of considerable duration occasionally attains quite large dimensions. 1 CONF LICT OF I NTEREST None declared. FUN DING INF ORMATION We have research funding from the university O R C I D Fumio Ide

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“…AOT is a benign odontogenic tumor that is more common in women than men with the peak incidence in the second decades of life [17], [32]. The lesions are more prevalent in the maxilla and 90% of them occur in the anterior portion of the jaws [17], [33]. In more than 70% of cases, AOT is in association with an impacted or un-erupted tooth, mostly maxillary canine followed by lateral incisors and mandibular premolars [17].…”

Section: • Adenomatoid Odontogenic Tumor (Aot)mentioning

confidence: 99%

Vulnerability and Weaknesses of Eating Habits of Overweight School Children as an Entry Risk for COVID-19

Metwally

Shaaban

Mahmoud

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: In developing countries, overweight among children becomes an alarming problem and a health concern. Obesity is a factor in disease severity of coronavirus disease (COVID-19) having the greatest impact on patients. AIM: The aim of this study was to determine the prevalence of overweight in some of the Egyptian governmental primary school children, its nutritional and socioeconomic determinants. Special focus was directed to identify the current dietary practices including risky nutritional habits of overweight children as a weak point leading to increasing their vulnerability to catching COVID-19 infection. METHODS: A cross-sectional observational study was conducted on primary school children aged 6–12 years. General demographic data, socioeconomic data, dietary pattern, intake of a diversity of nutrient-rich food versus calorie-dense food, and anthropometrical data were collected. RESULTS: Of 1600 child, there were 8% overweight who are considered at risk of COVID-19 infection. Considering the weekly share of the stomach, only one-third of the food consumed by overweight children is nutrient-rich, with high consumption of French fries and Candies (once per day among 95% and 78 % of overweight children, respectively). Moreover, 90% of them consume sugar-sweetened beverages (SSB) more than once per day. The majority of overweight children belonged to small, middle- income families, and had illiterate or read and write mothers. CONCLUSION: Overweight children eat narrow diversity of nutrient-rich food that includes vegetables, fruits, protein, and dairy products. They eat more calorie-dense foods, every day. The increase of family income increased the likelihood of having overweight children with a high intake of SSB, candies, and chips; consumption of snacks between meals and before sleep. Protective predictors against overweight were highly educated mothers, taking breakfast before school, having dinner, and taking meals on time. RECOMMENDATION: Nutritional behavioral education aiming at choosing nutritious and varied options of food that is effective for improving children’s nutritional status is the key to decreasing vulnerability toward COVID 19.

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Adenomatoid odontogenic tumor: An updated analysis of the cases reported in the literature

Cited by 55 publications

References 32 publications

Peripheral adenomatoid odontogenic tumor in a cloak of an epulis: report of a rare case

Peripheral adenomatoid odontogenic tumor in a cloak of an epulis: report of a rare case

Recurrence of adenomatoid odontogenic tumor

Vulnerability and Weaknesses of Eating Habits of Overweight School Children as an Entry Risk for COVID-19

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