Adenomatoid odontogenic tumor: What is the true nature?

Thakur, Arush; Tupkari, Jagdish Vishnu; Joy, Tabita; Hanchate, Amrut V.

doi:10.1016/j.mehy.2016.10.024

Cited by 17 publications

(18 citation statements)

References 20 publications

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“…Adenomatoid odontogenic tumor (AOT) is a benign, slowgrowing odontogenic tumor characterized by microscopic ductlike structures [1,2]. AOT is considered the fourth most common odontogenic tumor, accounting for 2.2-7.1% of them [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

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Maxillary extrafollicular adenomatoid odontogenic tumor: root resorption and involvement of the maxillary sinus and nasal cavity

Lombardi

Sorrentino

Arianna

et al. 2021

J Oral Med Oral Surg

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Adenomatoid odontogenic tumor (AOT) is a benign, slow-growing lesion and it is considered the fourth most common odontogenic tumor. AOT affects more frequently the young subjects with a predilection for the second and third decades of life. We present here the case of a 36-year-old man affected by large extrafollicular AOT which caused roots resorption of multiple teeth. The lesion involved the entire right maxillary bone and extended into the right maxillary sinus up to the orbital floor and the nasal cavity. Intra-oral surgical excision of the AOT and functional endoscopic sinus surgery led to complete clinical healing in absence of local recurrences.

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Section: Discussionmentioning

confidence: 99%

“…At histopathological analysis AOT presents a so-called "duct-like structures" formed by spindle-shape or cuboidal epithelial cells associated with minimal stroma and surrounded by a well-defined fibrous capsule [1,2].…”

Section: Discussionmentioning

confidence: 99%

Maxillary extrafollicular adenomatoid odontogenic tumor: root resorption and involvement of the maxillary sinus and nasal cavity

Lombardi

Sorrentino

Arianna

et al. 2021

J Oral Med Oral Surg

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“…For the follicular variant, there is histologic and immunohistochemical evidence that it arises from the reduced enamel epithelium of the dental follicle, whereas origin of the extrafollicular variant is less clear [11, 12]. Philipsen et al [2] argued that the identical histology in all AOT variants points towards a common origin and implicate the dental lamina or its remains.…”

Section: Discussionmentioning

confidence: 99%

Surgical Management of Extrafollicular Variant of Adenomatoid Odontogenic Tumor in the Maxillary Posterior Region

Monaca

Gioia

Pompa

et al. 2019

Case Reports in Dentistry

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Background. Adenomatoid odontogenic tumor (AOT) is a relatively uncommon benign neoplasm of odontogenic epithelial origin, accounting for less than 5% of odontogenic tumors. Case Report. The reported case describes morphological characteristics, clinical course, radiographic and histopathological features, and surgical therapy of an extrafollicular variant of AOT in the maxillary posterior region. An asymptomatic swelling on the left side in the posterior region of the maxilla, gradually increased since approximately 12 months, developed in a 16-year-old Caucasian female patient. Radiographic images revealed a well-defined, unilocular radiolucency, with some small foci of radiopacity inside, and root resorption of the first and second molars. On the base of the histological examination of the specimen retrieved by incisional biopsy, the diagnosis of AOT was made, and the conservative surgical enucleation of the lesion was performed. Discussion. The present case was reported in agreement with an extensive review, in which it was recommended to discontinue reporting classic follicular cases because their clinicopathological profile was well-known, but to continue reporting well-documented cases of the extrafollicular variant, with indication of the exact position. Conclusion. The present case was reported in order to expand the knowledge about the clinical behavior and surgical treatment of the extrafollicular variant of AOT.

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“…25 Similarly, Thakur et al proposed that the term AOT was most apt for this entity. 26 A molecular study by Razavi et al showed that the Ki-67 labelling index was lower in AOTs as compared to SMAs, signifying a hamartomatous nature. 27 However, using a human androgen receptor gene polymorphism assay, Gomes et al found that AOTs are monoclonal and therefore neoplastic.…”

Section: Adenomatoid Odontogenic Tumourmentioning

confidence: 99%

Controversies in Odontogenic Tumours: Review

Siwach

Joy

Tupkari

et al. 2017

SQUMJ

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Odontogenic tumours are lesions that occur solely within the oral cavity and are so named because of their origin from the odontogenic (i.e. tooth-forming) apparatus. Odontogenic tumours comprise a variety of lesions ranging from non-neoplastic tissue proliferations to benign or malignant neoplasms. However, controversies exist regarding the pathogenesis, categorisation and clinical and histological variations of these tumours. The recent 2017 World Health Organization classification of odontogenic tumours included new entities such as primordial odontogenic tumours, sclerosing odontogenic carcinomas and odontogenic carcinosarcomas, while eliminating several previously included entities like keratocystic odontogenic tumours and calcifying cystic odonogenic tumours. The aim of the present review article was to discuss controversies and recent concepts regarding odontogenic tumours so as to increase understanding of these lesions.

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Adenomatoid odontogenic tumor: What is the true nature?

Cited by 17 publications

References 20 publications

Maxillary extrafollicular adenomatoid odontogenic tumor: root resorption and involvement of the maxillary sinus and nasal cavity

Maxillary extrafollicular adenomatoid odontogenic tumor: root resorption and involvement of the maxillary sinus and nasal cavity

Surgical Management of Extrafollicular Variant of Adenomatoid Odontogenic Tumor in the Maxillary Posterior Region

Controversies in Odontogenic Tumours: Review

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