Adenomatoid tumour of the uterus is frequently associated with iatrogenic immunosuppression

Tamura, Daisuke; Maeda, Daichi; Halimi, Sultan Ahmad; Okimura, Masato; Kudo-Asabe, Yukitsugu; Ito, Satoru; Sato, Naoki; Shibahara, Junji; Nanjo, Hiroshi; Goto, Akiteru

doi:10.1111/his.13726

Cited by 19 publications

(18 citation statements)

References 32 publications

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“…TRAF7, a member in the tumor necrosis factor (TNF) receptor-associated factor family, is an E3-ubiquitin ligase in the NF-kB signaling pathway to regulate diverse processes such as transcription, survival, and cytokine production. Recurrent mutations in TRAF7 are present in a subset of meningiomas [32][33][34], intraneural perineuriomas [35], well-differentiated papillary mesotheliomas [36,37], most adenomatoid tumors of the genital type [38,39], and rare cases of diffuse malignant pleural mesothelioma [7]. The two TRAF7 mutations p.S561R and p.Q613E in localized pleural mesotheliomas are located in one of the seven Cterminal WD40 domain repeats.…”

Section: Discussionmentioning

confidence: 99%

“…The two TRAF7 mutations p.S561R and p.Q613E in localized pleural mesotheliomas are located in one of the seven Cterminal WD40 domain repeats. In fact, the pathogenic p. S561R mutation is the most common TRAF7 alteration in adenomatoid tumors of the genital type and intraneural perineuriomas [35,38,39]. While the functional role of the TRAF7 p.Q613E mutation has not been clearly established, similar mutations nearby, such as p.K615E, are pathogenic in a subset of meningiomas [34].…”

Section: Discussionmentioning

confidence: 99%

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Molecular characterization of localized pleural mesothelioma

et al. 2020

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Localized pleural mesothelioma is a rare solitary circumscribed pleural tumor that is microscopically similar to diffuse malignant pleural mesothelioma. However, the molecular characteristics and nosologic relationship with its diffuse counterpart remain unknown. In a consecutive cohort of 1110 patients with pleural mesotheliomas diagnosed in 2005-2018, we identified six (0.5%) patients diagnosed with localized pleural mesotheliomas. We gathered clinical history, evaluated the histopathology, and in select cases performed karyotypic analysis and targeted next-generation sequencing. The cohort included three women and three men (median age 63; range 28-76), often presenting incidentally during radiologic evaluation for unrelated conditions. Neoadjuvant chemotherapy was administered in two patients. All tumors (median size 5.0 cm; range 2.7-13.5 cm) demonstrated gross circumscription (with microscopic invasion into lung, soft tissue, and/or rib in four cases), mesothelioma histology (four biphasic and two epithelioid types), and mesothelial immunophenotype. Of four patients with at least 6-month follow-up, three were alive (up to 8.9 years). Genomic characterization identified several subgroups: (1) BAP1 mutations with deletions of CDKN2A and NF2 in two tumors; (2) TRAF7 mutations in two tumors, including one harboring trisomies of chromosomes 3, 5, 7, and X; and (3) genomic near-haploidization, characterized by extensive loss of heterozygosity sparing chromosomes 5 and 7. Localized pleural mesotheliomas appear genetically heterogeneous and include BAP1-mutated, TRAF7-mutated, and near-haploid subgroups. While the BAP1-mutated subgroup is similar to diffuse malignant pleural mesotheliomas, the TRAF7-mutated subgroup Yin P. Hung

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Molecular characterization of localized pleural mesothelioma

et al. 2020

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“…Integration of EBV was assessed by in situ hybridization (ISH) for the case with increased lymphocyte infiltration (n = 37) in the test cohort, as previously described 28 . EBV-encoded small RNA (EBER)-ISH was performed using the INFORM EBER probe (800–2842, Ventana Medical Systems, Tucson, AZ, USA) and the Discovery XT autostainer (Ventana), according to the manufacturer’s protocol.…”

Section: Methodsmentioning

confidence: 99%

Prognostic role of ARID1A negative expression in gastric cancer

Ashizawa

Saito

Min

et al. 2019

Sci Rep

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AT-rich interactive domain 1A ( ARID1A ) functions as a tumor suppressor and several therapeutic targets in ARID1A -mutated cancers are under development. Here, we investigated the prognostic value of ARID1A for gastric cancer and its association with expression of PD-L1 and p53. ARID1A expression was examined by immunohistochemistry and negative expression of ARID1A was detected in 39 (19.5%) of 200 cases in a test cohort and in 40 (18.2%) of 220 cases in a validation cohort. Negative expression of ARID1A was associated with worse overall survival in undifferentiated cases, particularly early-stage cases. Negative expression of ARID1A was detected in 11 (50%) of 22 PD-L1-positive cases and in 68 (17.1%) of 398 PD-L1-negative cases in a combined cohort. Negative expression of ARID1A was detected in 45 (22%) of 205 p53-positive cases and in 34 (15.8%) of 215 p53-negative cases in a combined cohort. In addition, expression of EZH2, a potential synthetic lethal target in ARID1A -mutated tumors, was detected in 79 ARID1A-negative cases. An ARID1A-knockdown gastric cancer cell line was subjected to microarray analysis, but no actionable targets or pathways were identified. The present results indicate that ARID1A may serve as an early-stage prognostic biomarker for undifferentiated gastric cancer.

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“…[63][64][65] Multifocal and diffuse architecture are more often encountered in the context of iatrogenic immunosuppression. 61 The tumor is characterized by gland-like cystic/microcystic spaces lined by flattened cells or cords and tubules made of cuboidal cells with abundant eosinophilic cytoplasm. These structures dissect smooth muscle fascicles and desmoplastic or edematous stroma.…”

Section: Discussionmentioning

confidence: 99%

Adenomatoid tumor of the skin: Differential diagnosis of an umbilical erythematous plaque

et al. 2020

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Adenomatoid tumors are benign tumors of mesothelial origin that are usually encountered in the genital tract. Although they have been observed in other organs, the skin appears to be a very rare location, with only one case reported in the literature to our knowledge. We report a second case of an adenomatoid tumor, arising in the umbilicus of a 44-year-old woman. The patient presented with an 8-month-old erythematous and firm plaque under the umbilicus. A skin biopsy showed numerous microcystic spaces dissecting a fibrous stroma and lined by flattened to cuboidal cells with focal intraluminal papillary formation. This little-known diagnosis constitutes a diagnostic pitfall for dermatopathologists and dermatologists, and could be misdiagnosed as other benign or malignant entities. Through this case report, a practical approach and diagnostic keys have been devised to avoid misdiagnosis and overtreatment.

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Adenomatoid tumour of the uterus is frequently associated with iatrogenic immunosuppression

Abstract: Uterine AT is an immunosuppression-associated mesothelial lesion characterised by p16 overexpression.

Cited by 19 publications

References 32 publications

Molecular characterization of localized pleural mesothelioma

Molecular characterization of localized pleural mesothelioma

Prognostic role of ARID1A negative expression in gastric cancer

Adenomatoid tumor of the skin: Differential diagnosis of an umbilical erythematous plaque

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