Adenomyoepithelioma of the breast with features of malignancy

Pauwels, C; Potter, Christian R. De

doi:10.1111/j.1365-2559.1994.tb01280.x

Cited by 36 publications

(25 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…ABC peroxidase, x150 LGASC was intermingled with AME [29]. Furthermore, cases of AME intermingled with a spindle cell neoplastic proliferation very similar to that seen in our cases 4-6 have been previously reported [2,5,17,18,25,29]. This probably indicates that the two components represent a single neoplastic process.…”

Section: Discussionsupporting

confidence: 73%

Adenomyoepithelioma of the breast associated with low-grade adenosquamous and sarcomatoid carcinomas

Foschini

Eusebi

Pizzicannella

et al. 1995

Vichows Archiv A Pathol Anat

View full text Add to dashboard Cite

Six cases of invasive breast carcinoma with unusual morphological features are reported. The ages of the female patients ranged from 46 to 79 years (mean 60.5). All tumours had areas typical of an adenomyoepithelioma. In three cases adenomyoepithelioma gradually merged with low-grade adenosquamous carcinoma. In the other three patients a sarcomatoid carcinoma was associated with adenomyoepithelial areas. A common origin is proposed for these neoplasms, which extends the morphological spectrum of epi-myoepithelial cell tumours.

show abstract

Section: Discussionsupporting

confidence: 73%

Adenomyoepithelioma of the breast associated with low-grade adenosquamous and sarcomatoid carcinomas

Foschini

Eusebi

Pizzicannella

et al. 1995

Vichows Archiv A Pathol Anat

View full text Add to dashboard Cite

show abstract

“…Local recurrences have been described in 20 patients [7,20,28,32,37,42,45,48,53,60,64,69]. The frequency of recurrences ranged from one to six.…”

Section: Markersmentioning

confidence: 99%

“…The time within which the recurrences occurred ranged from 4 months to 23 years after initial diagnosis. The likelihood of recurrence seems to be associated with incomplete removal [48], the presence of cellular pleomorphism [7,14,32,45,64,69], mitoses [7,14,37,42,45,53,60,64,69], necrosis [37,45,60], invasion of the surrounding tissue [45,53], and association with other types of malignant tumors, such as undifferentiated carcinoma [37], invasive ductal carcinoma [45], leiomyosarcoma [7], myoepithelial carcinoma [60], acantholytic squamous cell carcinoma [20], and osteosarcoma [53].…”

Section: Markersmentioning

confidence: 99%

“…The total of 125 cases included 35 in which the tumors were considered to be potentially malignant [7,9,11,14,18,20,25,28,32,37,40,42,45,53,60,64,69,70] on the basis of either the features of the adenomyoepithelioma itself or the association with other types of malignant tumors ( Table 2). The presence of mitoses [7,9,11,14,18,32,37,40,42,45,53,64,69,70], with mitotic counts of up to 16 per 10 HPF [9,14,18,32,40,42,45,64,69], cellular pleomorphism [7,9,11,18,20,32,40,...…”

Section: Markersmentioning

confidence: 99%

“…Although most of the adenomyoepitheliomas reported have been considered to be benign [10, 16, 19, 22-24, 26, 31, 32, 36, 48-50, 55, 58, 60, 62, 63, 66, 68], they can recur locally [7,20,28,32,37,42,45,48,53,60,64,69], progress subsequently to a (more) malignant state [20,28,32,42,45,53,60], and give rise to metastases [9,20,32,37,45,53,60,64]. Morphological features of malignancy that could predict the potential for local recurrence and/or metastasis are not well established.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Malignant adenomyoepithelioma of the breast with metastasis in the thyroid gland 12 years after excision of the primary tumor

Bult¹,

Verwiel

Wobbes

et al. 2000

Virchows Archiv

View full text Add to dashboard Cite

We describe a patient who was admitted to our hospital with an enlarged left lobe of the thyroid gland. Since fine-needle aspiration showed atypical follicular cells, a surgical exploration followed. Owing to extensive tumor infiltration into the surrounding tissues curative surgery was not possible, and only an incisional biopsy was taken. Histological examination of this biopsy revealed a mixed tumor composed of epithelial and myoepithelial cells. A primary thyroid tumor, metastasis of a salivary gland, and a skin appendage tumor could be excluded based on clinical examination, conventional histology, and immunohistochemistry. A tumor of the left breast treated 12 years earlier had originally been classified as an intraductal/intracystic carcinoma with focal invasion, but was re-examined. Using immunohistochemistry, the breast tumor was reclassified as a malignant adenomyoepithelioma. The current tumor was apparently a metastasis from this primary breast tumor. An updated review of the literature is given, including current knowledge on histological and immunohistochemical features of adenomyoepithelioma of the breast, with special attention to the reported pathological characteristics of recurrent and malignant tumors. Based on the reported pathological characteristics of recurrent and metastatic tumors we offer a diagnostic tool for identifying potentially malignant and recurrent tumors.

show abstract

Adenomyoepithelioma of the breast: Report of two cases with prominent cystic changes and intranuclear inclusions

1998

View full text Add to dashboard Cite

Adenomyoepithelioma is a rare breast tumor. Histologically it may disclose different patterns of growth, and some additional features may result in diagnostic errors. We describe 2 cases of adenomyoepithelioma of the breast initially examined by fine‐needle aspiration biopsy (FNAB). Cytologic features included hypercellularity, clusters of epithelial and myoepithelial cells with occasional intranuclear inclusions, prominent apocrine metaplasia, and foam cells. Histologically, both tumors were diagnosed as adenomyoepithelioma tubular‐variant, with prominent myoepithelial clear cells, apocrine metaplasia, and foci of squamous metaplasia. Immunohistochemically, the tumors showed strong positivity for keratins CAM 5.2, AE1/AE3, and EMA in the epithelial component, while the myoepithelial cells reacted with muscle‐specific actin (A14 and HHF35) and S‐100 protein. We point out that FNAB in this rare tumor may exhibit a varied spectrum of cells that may result in confusion with other lesions, and we call attention to the presence of intranuclear inclusions. The latter observation in the present cases by cytologic and histologic assessment provides an additional feature to the morphological characteristics of adenomyoepithelioma of the breast. Diagn. Cytopathol. 1998;19:55–58. © 1998 Wiley‐Liss, Inc.

show abstract

Adenomyoepithelioma of the breast with features of malignancy

Cited by 36 publications

References 4 publications

Adenomyoepithelioma of the breast associated with low-grade adenosquamous and sarcomatoid carcinomas

Adenomyoepithelioma of the breast associated with low-grade adenosquamous and sarcomatoid carcinomas

Malignant adenomyoepithelioma of the breast with metastasis in the thyroid gland 12 years after excision of the primary tumor

Adenomyoepithelioma of the breast: Report of two cases with prominent cystic changes and intranuclear inclusions

Contact Info

Product

Resources

About