Adenomyoepithelioma of the skin: a case report with immunohistochemical and ultrastructural observations

Abstract

We predict that the tumour will behave in a benign fashion. There is no evidence of recurrence or metastasis 28 months later.

Adenomyoepithelioma of Skin

“…While myoepitheliomas are benign neoplasms consisting exclusively of myoepithelial cells embedded in a myxoid stroma, adenomyoepithelioma shows in addition to myoepithelial cells a second component displaying various degrees of epithelial-ductal differentiation [9,10]. Adenomyoepitheliomas of the breast have been further classified as tubular, lobulated or spindled subtype [3].…”

“…Cutaneous myoepitheliomas occur usually in children and young adults and are located on the extremities, while mixed apocrine tumors affect older individuals and are usually found on the face [9,12]. The few cases of cutaneous adenomyoepitheliomas that have been described to date were reported in older patients and were located on the extremities and on the trunk [8,9].…”

“…The few cases of cutaneous adenomyoepitheliomas that have been described to date were reported in older patients and were located on the extremities and on the trunk [8,9].…”

“…The neoplasm is composed of scattered tubules lined by ductlike cells in a background of myoepithelial cells [3]. It is exceedingly rare in the skin, with only few cases reported till date [4][5][6][7]. We present a case of a 25 year old female patient with a nodular lesion over the chin that revealed histopathologic and immunohistochemical features of adenomyoepithelioma.…”

Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours?

“…However, I am a little surprised that in both articles the problem of terminology is not discussed. Adenomyoepithelioma of the breast [14] is identical in histological and immunohistochemical structure to epithelial-myoepithelial carcinoma of the salivary glands, the lung [19,30,32] or the skin [15,31]. Such different terminology for a histologically well-defined tumour should be avoided: identical nomenclature should be used for tumours with identical histological architecture, regardless of their localization in different organs.…”