Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes

Maheshwari, Abha; Gurunath, Sumana; Fatima, F.; Bhattacharya, Siladitya

doi:10.1093/humupd/dms006

Cited by 191 publications

(146 citation statements)

References 50 publications

(54 reference statements)

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“…The pathological process of EM comprises periodic bleeding, migration of uterine cells and their attachment to other organs. In general, EM is only seen in women of childbearing age, mostly at the age of 25-45 years (3,4). The major symptoms of the disease are dysmenorrhea, chronic pelvic pain and infertility that seriously affect the quality of life of young women (5).…”

Section: Introductionmentioning

confidence: 99%

Protective role of propofol in endometriosis and its mechanism

Feng

Sun

2018

Exp Ther Med

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Abstract. Endometriosis (EM) is a common benign gynecological disorder. The present study aimed to investigate the potential role of propofol, a commonly used intravenous anesthetic agent, in the pathogenesis of EM. The EM cell line CRL-7566 was used in the present study. CRL-7566 cells were first treated with various concentrations of propofol (0, 1, 5 or 10 µg/ml) for specific duration, and the cell viability and apoptotic rate were determined by performing an MTT and a flow cytometric cell apoptosis assay, respectively. The protein and mRNA levels of cell proliferation-and apoptosis-associated genes were detected by western blot and reverse-transcription quantitative polymerase chain reaction, respectively. The results demonstrated that propofol inhibited CRL-7566 cell proliferation in a dose-and time-dependent manner. CRL-7566 cell apoptosis was dose-dependently induced by propofol treatment. In addition, propofol treatment significantly increased the levels of forkhead box (FOX)O1, FOXO3, Bim, pro-caspase-3, active caspase-3, p53 and p21. In conclusion, the present study suggested that propofol inhibited the proliferation and induced apoptosis of EM cells via inducing the expression/activation of multiple associated genes/proteins, indicating a protective role of propofol in EM.

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Section: Introductionmentioning

confidence: 99%

Protective role of propofol in endometriosis and its mechanism

Feng

Sun

2018

Exp Ther Med

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“…Costello et al [3 ]reported that the presence of adenomyosis did not adversely affect the outcome in women undergoing in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) treatment. The most recent systematic review of five existing studies failed to draw any definite conclusions about the effect of adenomyosis on the outcomes of assisted reproductive technology because of major differences in study design and populations [4]. …”

Section: Introductionmentioning

confidence: 99%

Effect of Adenomyosis on In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcomes in Infertile Women: A Retrospective Cohort Study

Yan

Ding

Tang

et al. 2013

Gynecol Obstet Invest

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Aims: To study the effect of adenomyosis on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes in infertile patients. Methods: We performed a retrospective, database-searched cohort study based on 10,268 patients undergoing controlled ovarian hyperstimulation and IVF/ICSI between 2009 and 2011 in our unit. Adenomyosis was diagnosed by transvaginal ultrasound. A high-quality matched cohort study with strict inclusion criteria was conducted. We compared the basic characteristics and main IVF/ICSI outcomes between the two groups. Results: We identified 83 patients with adenomyosis, of whom we included 77, and strictly matched them to 77 patients without adenomyosis. Higher day 3 estrogen levels and a longer duration of gonadotropin stimulation days were found in women with adenomyosis compared to control subjects. Patients with adenomyosis had a nonsignificant trend toward a lower clinical pregnancy rate and a higher miscarriage rate (p = 0.103 and 0.09, respectively). The delivery rate was significantly lower in the adenomyosis group in comparison to the matched controls (p = 0.022). Conclusions: Within the limitations of a retrospective study (albeit with a remarkably large number of observations), our results suggest that transvaginal ultrasound-diagnosed adenomyosis could have a negative impact on the main IVF/ICSI outcomes. Improving the diagnostic validity and scoring of disease severity in patients with adenomyosis is suggested.

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“…планируют сохранить свою фертильность, а чаще всего еще даже не реализовали свой репродуктивный потенциал [9,10].…”

Section: Abstract: Adenomyosis Myoma Uteri Hormone Therapy Osada Ounclassified

Successful metroplastic operation after medical therapy with selective modulators of progesteron receptors in a patient with proliferating myoma and adenomyosis (case report)

Цхай¹,

Grebennikova²,

Yametov³

et al. 2016

Probl. reprod.

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Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes

Abstract: Further studies are needed to determine the natural history of adenomyosis and implications for fertility and reproductive outcomes, with and without treatment. Currently, there is no evidence that we should find and treat adenomyosis in patients who wish to conceive.

Cited by 191 publications

References 50 publications

Protective role of propofol in endometriosis and its mechanism

Protective role of propofol in endometriosis and its mechanism

Effect of Adenomyosis on In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcomes in Infertile Women: A Retrospective Cohort Study

Successful metroplastic operation after medical therapy with selective modulators of progesteron receptors in a patient with proliferating myoma and adenomyosis (case report)

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Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes

Abstract: Further studies are needed to determine the natural history of adenomyosis and implications for fertility and reproductive outcomes, with and without treatment. Currently, there is no evidence that we should find and treat adenomyosis in patients who wish to conceive.

Cited by 191 publications

References 50 publications

Protective role of propofol in endometriosis and its mechanism

Protective role of propofol in endometriosis and its mechanism

Effect of Adenomyosis on In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcomes in Infertile Women: A Retrospective Cohort Study

Successful metroplastic operation after medical therapy with selective modulators of progesteron receptors in a patient with prolifera­ting myoma and adenomyosis (case report)

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Successful metroplastic operation after medical therapy with selective modulators of progesteron receptors in a patient with proliferating myoma and adenomyosis (case report)