Adenomyosis: What the Patient Needs

Alabiso, G.; Alio, L.; Arena, Saverio; Prun, Allegra Barbasetti di; Bergamini, Valentino; Berlanda, Nicola; Busacca, Mauro; Candiani, Massimo; Centini, Gabriele; Cello, Annalisa Di; Exacoustòs, C.; Fedele, Luigi; Fuggetta, Eliana; Gabbi, Laura; Geraci, E.; Imperiale, Ludovica; Lavarini, E.; Incandela, Domenico; Lazzeri, Lucia; Luisi, Stefano; Maiorana, Antonio; Maneschi, Francesco; Mannini, Luca; Mattei, Alberto; Muzii, Ludovico; Pagliardini, Luca; Perandini, Alessio; Perelli, Federica; Pinzauti, Serena; Porpora, Maria Grazia; Remorgida, Valentino; Maggiore, Umberto Leone Roberti; Seracchioli, Renato; Solima, Eugenio; Somigliana, Edgardo; Tosti, Claudia; Venturella, Roberta; Vercellini, Paolo; Viganò, Paola; Vignali, Michele; Zannoni, Letizia; Zullo, Fulvio; Zupi, Errico

doi:10.1016/j.jmig.2015.12.017

Cited by 39 publications

(25 citation statements)

References 103 publications

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“…Although the age of onset is getting younger and incidence is rising in recent years, the mechanism of pathogenesis of adenomyosis is still incompletely understood. Both hysterectomy and many other kinds of conservative treatments can fail to completely relieve patient’s sufferings, and treatment options are especially limited for those planning for future pregnancies[ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Abnormal expression of Nrf2 may play an important role in the pathogenesis and development of adenomyosis

Chen

Zhou

et al. 2017

PLoS ONE

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ObjectiveTo explore the expression level of Nrf2 in adenomyosis and study the mechanism of abnormal expression of Nrf2 in the pathogenesis of adenomyosis.MethodsWestern blot, immunohistochemistry(IHC) and real time PCR were used to measure Nrf2 expression levels in tissue and cell samples. Knockdown and overexpression of Nrf2 were used to investigate the variation of migration ability of endometrial glandular cells as well as the regulatory mechanism.ResultsNrf2 protein levels were significantly higher in the eutopic and ectopic endometrial glands when compared with control cases using IHC and western blot methods. (p< 0.05). However, there was no statistical difference in Nrf2 mRNA expression levels between the adenomyosis and control groups. Using an agonist and Nrf2 siRNA, we regulated the Nrf2 protein levels of primary cultured endometrial glandular cells. With increased expression of Nrf2, cell scratch assay showed that the agonist-treated group migrated significantly faster than the control group, with MMP9 protein level markedly elevated. In contrast, Nrf2 siRNA-treated group migrated slower than the control group, with decreased expression of MMP9 protein. All of the scratching healing spaces and protein levels between the treated and control groups were statistically significant (p< 0.05).ConclusionsAbnormal expression of Nrf2 may play an important role in the pathogenesis and development of adenomyosis. Specified reduction of Nrf2 expression could prove to be a new therapeutic target in the clinical treatment of adenomyosis.

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Section: Introductionmentioning

confidence: 99%

Abnormal expression of Nrf2 may play an important role in the pathogenesis and development of adenomyosis

Chen

Zhou

et al. 2017

PLoS ONE

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“…At TVUS, ectopic endometrial glands appear as echogenic nodules, striations radiating from the endometrium into the myometrium or myometrial cysts, whereas muscular hyperplasia and hypertrophy are seen as focal or diffuse myometrial thickening or asymmetric globular uterine enlargement. MRI is particularly useful in detecting the thickening, hyperplasia, or disruption of the uterine junctional zone (JZ) located between the endometrium and the internal myometrium [8,9]. It has been shown that the accuracies of two-dimensional TVUS, MRI, and histology are comparable in diagnosing adenomyosis [8].…”

Section: Introductionmentioning

confidence: 99%

“…MRI is particularly useful in detecting the thickening, hyperplasia, or disruption of the uterine junctional zone (JZ) located between the endometrium and the internal myometrium [8,9]. It has been shown that the accuracies of two-dimensional TVUS, MRI, and histology are comparable in diagnosing adenomyosis [8].…”

Section: Introductionmentioning

confidence: 99%

Adenomyosis and infertility: is there a causal link?

Vercellini

Bonfanti

Berlanda

2019

Expert Review of Endocrinology & Metabolism

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“…Adenomyosis is a common benign condition in women of reproductive age and it characterized by the presence of endometrial glands and stroma within the uterine myometrium [ 1 , 2 ].Adenomyosis is a serious disease for women because of dysmenorrheal, infertility, abnormal uterine bleeding, chronic pelvic pain and menorrhagia. A series of hypotheses that attempt to explain the genesis of adenomyosis has been established [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Elevated plasma levels of lysophosphatidic acid and aberrant expression of lysophosphatidic acid receptors in adenomyosis

et al. 2017

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BackgroundGiven the important roles of the receptor-mediated lysophosphatidic acid (LPA) signaling in both reproductive tract function and gynecological cancers, it will be informative to investigate the potential role of LPA in the development of adenomyosis. The objective of this study was to evaluate the levels of LPA in plasma and the expression of six LPA receptors in the endometrial tissue collected from women with and without adenomyosis.MethodsPlasma and endometrial tissue samples were collected form women with and without adenomyosis. The levels of LPA in plasma were determined by using high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Immunohistochemistry was performed to evaluate the expression of six LPA receptors (LPA1–6) in endometrial tissue samples. The effects of LPA on IL-8 production, VEGF production and cell proliferation in human endometrial stromal cells (ESCs) were also assessed.ResultsLPA1 staining was localized to the cytoplasm, membrances of the epithelial cells of the endometrial glands, and there was little staining in the stromal cells. LPA2–5 staining were localized to the nuclei of stromal and glandular cells. Plasma levels of LPA were increased in adenomyosis. LPA1, LPA4 and LPA5 immunoreactivity were significantly higher in the adenomyosis group than in the control group, while LPA2 and LPA3 immunoreactivity were significantly lower in the adenomyosis group than in the control group. LPA6 was undetectable in the endometria. LPA induced the release of IL-8 from ESCs but did not affect cell proliferation and VEGF production.ConclusionThese results indicate that elevated plasma levels of LPA and aberrant expression of LPA receptors in the endometria may be associated with the development of adenomyosis.

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Adenomyosis: What the Patient Needs

Cited by 39 publications

References 103 publications

Abnormal expression of Nrf2 may play an important role in the pathogenesis and development of adenomyosis

Abnormal expression of Nrf2 may play an important role in the pathogenesis and development of adenomyosis

Adenomyosis and infertility: is there a causal link?

Elevated plasma levels of lysophosphatidic acid and aberrant expression of lysophosphatidic acid receptors in adenomyosis

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