Adenosine—A drug with myriad utility in the diagnosis and treatment of arrhythmias

Gupta, Anunay; Lokhandwala, Yash; Rai, Nitish; Malviya, Amit

doi:10.1002/joa3.12453

Cited by 24 publications

(23 citation statements)

References 62 publications

(144 reference statements)

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“…Automatic diagnosis of ECG is one of the hot spots in the field of ECG research, especially in the field of real-time diagnosis of ECG signals [ 5 ]. The variability of heartbeat waveforms in various heart disease patients and the fact that the recording devices of heartbeat signals are often influenced by the working environment and introduce a large number of different types of noise information make the effective diagnosis of ECG very difficult, and it is still a challenging research problem.…”

Section: Related Workmentioning

confidence: 99%

Online Automatic Diagnosis System of Cardiac Arrhythmias Based on MIT-BIH ECG Database

Yan

Zhang

2021

Journal of Healthcare Engineering

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Arrhythmias are a relatively common type of cardiovascular disease. Most cardiovascular diseases are often accompanied by arrhythmias. In clinical practice, an electrocardiogram (ECG) can be used as a primary diagnostic tool for cardiac activity and is commonly used to detect arrhythmias. Based on the hidden and sudden nature of the MIT-BIH ECG database signal and the small-signal amplitude, this paper constructs a hybrid model for the temporal correlation characteristics of the MIT-BIH ECG database data, to learn the deep-seated essential features of the target data, combine the characteristics of the information processing mechanism of the arrhythmia online automatic diagnosis system, and automatically extract the spatial features and temporal characteristics of the diagnostic data. First, a combination of median filter and bandstop filter is used to preprocess the data in the ECG database with individual differences in ECG waveforms, and there are problems of feature inaccuracy and useful feature omission which cannot effectively extract the features implied behind the massive ECG signals. Its diagnostic algorithm integrates feature extraction and classification into one, which avoids some bias in the feature extraction process and provides a new idea for the automatic diagnosis of cardiovascular diseases. To address the problem of feature importance variability in the temporal data of the MIT-BIH ECG database, a hybrid model is constructed by introducing algorithms in deep neural networks, which can enhance its diagnostic efficiency.

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Section: Related Workmentioning

confidence: 99%

Online Automatic Diagnosis System of Cardiac Arrhythmias Based on MIT-BIH ECG Database

Yan

Zhang

2021

Journal of Healthcare Engineering

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“…The minimum initially recommended dose is 6 mg intravenously, which can be increased by 6 mg to a maximum of 18 to 24 mg. Continuous ECG recording during administration of adenosine should always be performed . Also, adenosine can rarely cause atrial fibrillation, and in patients with manifest preexcitation at baseline, it can lead to ventricular fibrillation because AV nodal block will lead to rapid antegrade accessory pathway conduction .…”

Section: Discussionmentioning

confidence: 99%

Narrow Complex Tachycardias—Therapeutic and Diagnostic Role of Adenosine

2022

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“… 5 , 6 , 7 Dosage via the peripheral intravascular (IV) route is 6 mg, followed by 12 mg if the first dose is ineffective. 2 To achieve rhythm conversion, IV administration should be performed using a rapid bolus with an immediate normal saline solution (NSS) flush through a large vein (e.g., the antecubital vein) within 1–2 s. 7 , 8 This conventional method of adenosine administration is called the double syringe technique (DST). 2 This method generally requires an IV line and/or a T‐way stopcock, and two syringes.…”

Section: Introductionmentioning

confidence: 99%

“…5,6 Adenosine prolongs atrioventricular (AV) conduction and results in a transient AV block that is responsible for reentrant tachyarrhythmia termination. [5][6][7] Dosage via the peripheral intravascular (IV) route is 6 mg, followed by 12 mg if the first dose is ineffective. 2 To achieve rhythm conversion, IV administration should be performed using a rapid bolus with an immediate normal saline solution (NSS) flush through a large vein (e.g., the antecubital vein) within 1-2 s. 7,8 This conventional method of adenosine administration is called the double syringe technique (DST).…”

Section: Introductionmentioning

confidence: 99%

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Comparison between the double‐syringe and the single‐syringe techniques of adenosine administration for terminating supraventricular tachycardia: A pilot, randomized controlled trial

Kotruchin

Chaiyakhan

Kamonsri³

et al. 2022

Clinical Cardiology

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Background Adenosine has been recommended as a first‐line treatment for stable supraventricular tachycardia (SVT). Standard guidelines recommend 6‐mg of adenosine administered intravenously (IV) with an immediate 20‐ml IV bolus of normal saline solution (NSS; double syringe technique [DST]). However, a newly proposed single‐syringe technique (SST), in which adenosine is diluted with an up to 20 ml IV bolus of NSS, was found to be beneficial. Hypothesis We hypothesized that the SST was noninferior to the DST for terminating stable SVT. Methods A pilot multicenter, single‐blind, randomized controlled study was conducted at nine hospitals in north and northeast Thailand. Thirty patients who were diagnosed with stable SVT were randomized into two groups of 15, with one receiving adenosine via the DST and the other via the SST. We examined SVT termination, the average successful dose, and the complication rate of each group. Analyses were based on the intention‐to‐treat principle. Result The termination rate was 93.3% in the DST and 100% in the SST group ( p = 1.000), and the success rate of the first 6‐mg dose of adenosine was 73.3% and 80%, respectively ( p = 1.000). The total administered dose was 8.6 ± 5.1 mg in the DST group and 7.6 ± 4.5 mg in the SST group ( p = .608). No complications were found in either group. Conclusions The SST was non‐inferior to the DST for termination of SVT. However, a further definitive study with a larger sample size is required.

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Adenosine—A drug with myriad utility in the diagnosis and treatment of arrhythmias

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 24 publications

References 62 publications

Online Automatic Diagnosis System of Cardiac Arrhythmias Based on MIT-BIH ECG Database

Online Automatic Diagnosis System of Cardiac Arrhythmias Based on MIT-BIH ECG Database

Narrow Complex Tachycardias—Therapeutic and Diagnostic Role of Adenosine

Comparison between the double‐syringe and the single‐syringe techniques of adenosine administration for terminating supraventricular tachycardia: A pilot, randomized controlled trial

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