Adenosine accumulation causes metabolic disorders in testes and associates with lower testosterone level in obese mice

Yang, Xiao; Zhao, Yang; Sun, Qi; Yang, Yuxuan; Gao, Yan; Ge, Weifeng; Liu, Junhao; Xu, Xi; Zhang, Jianfa

doi:10.1002/mrd.23321

Cited by 6 publications

(2 citation statements)

References 53 publications

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“…The blood samples were kept at room temperature for 1 h. Then, the blood samples were centrifuged twice at 5,000 rpm for 10 min and the serum was transferred into new tubes. The chemiluminescent immunoassay method (Yang et al, 2020) was used to determine the quantity of the male testosterone and female estradiol. The mean values of male testosterone and female estradiol were calculated for the CK-and BP-fed voles.…”

Section: Hormone Determinationmentioning

confidence: 99%

Paper mulberry leaves as a potential sterilant: evidence from Microtus fortis—a laboratory study

Wang

Chen²,

Zhao

et al. 2023

Front. Plant Sci.

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IntroductionThe Yangtze vole (Microtus fortis) is a small herbivorous rodent that usually causes damage to crops and forests in China. Various measures were used to control their population including chemical rodenticides. However, rodenticides may cause secondary damage to the environment and the ecosystem. Therefore, the development of new rodent sterilants is urgent. Considering that some compounds of paper mulberry leaves have been verified that can inhibit the biosynthesis of sexual hormone, we aimed to explore the antifertility effect of paper mulberry leaves on M. fortis.MethodsIn this study, voles were divided into three groups including a male group, a female group, and a breeding group, and paper mulberry leaves were added into basal fodder of voles maintained in laboratory, of which the proportion of leaf weight was 50%. In each group, voles were fed with mixed fodder as treatment (BP) and voles were fed with basal fodder as contrast (CK).Results and discussionAfter feeding for more than 1 month, the results indicated that paper mulberry leaves attracted voles to feed, but inhibited their growth and reproduction. Since the second week, food intakes of BP have been significantly higher than CK (p< 0.05). However, weights of voles in male and female groups were 72.283 ± 7.394 g and 49.717 ± 2.278 g in the fifth week, and both were significantly reduced compared with their original weight (p< 0.05). Meanwhile, testicular volumes of male voles fed with BP were significantly smaller than CK (former: 318.000 ± 44.654 mm3, latter: 459.339 ± 108.755 mm3); the testosterone level, sperm number, and vitality of BP were obviously weaker than CK. Female uteruses and oophoron of BP grew slower, and the organ coefficients of uterus and oophoron fed BP were both significantly lower than CK (p< 0.05). The first reproduction of BP couple voles spent 45 days, while CK spent only 21 days. These results suggest that paper mulberry leaves could be the potential resource to produce sterilants to control rodent populations by delaying their sexual growth and reproduction. If it was practical, the apparent advantages of paper mulberry are that it is an abundant resource and the inhibitory effect could be effective in both male and female individuals. Our conclusion also supports the transformation of rodent management from lethal management to fertility control, which would be more ecologically friendly to agriculture and the ecosystem.

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Section: Hormone Determinationmentioning

confidence: 99%

Paper mulberry leaves as a potential sterilant: evidence from Microtus fortis—a laboratory study

Wang

Chen²,

Zhao

et al. 2023

Front. Plant Sci.

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“…Adenosine, a product of purine nucleotide and homocysteine catabolism has been implicated in the regulation of tissue damage in response to stressors, such as inflammation and hypoxia. In both diet-induced and genetically obese mice, adenosine accumulates in the testes, and has been causally linked to abnormalities of steroidogenesis in Leydig cells resulting in decreased production of testosterone [ 49 ].…”

Section: Obesity and Obesity Related Chronic Disorders And The Hpt Axismentioning

confidence: 99%

Obesity, type 2 diabetes, and testosterone in ageing men

Wittert

Grossmann

2022

Rev Endocr Metab Disord

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In the absence of obesity, adverse lifestyle behaviours, and use of medication such as opioids serum testosterone concentrations decrease by only a minimal amount at least until very advanced age in most men. Obesity is heterogeneous in its phenotype, and it is the accumulation of excess adipose tissue viscerally associated with insulin resistance, dyslipidaemia, inflammation, hypothalamic leptin resistance and gliosis that underpins the functional hypogonadism of obesity. Both central (hypothalamic) and peripheral mechanisms are involved resulting in a low serum total testosterone concentration, while LH and FSH are typically in the normal range. Peripherally a decrease in serum sex hormone binding globulin (SHBG) concentration only partially explains the decrease in testosterone and there is increasing evidence for direct effects in the testis. Men with obesity associated functional hypogonadism and serum testosterone concentrations below 16 nmol/L are at increased risk of incident type 2 diabetes (T2D); high testosterone concentrations are protective. The magnitude of weight loss is linearly associated with an increase in serum testosterone concentration and with the likelihood of preventing T2D or reverting newly diagnosed disease; treatment with testosterone for 2 years increases the probability of a positive outcome from a lifestyle intervention alone by approximately 40%. Whether the additional favourable benefits of testosterone treatment on muscle mass and strength and bone density and quality in the long-term remains to be determined.

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