Adenosine and Other Purinergic Products in Circadian Timing

Muheim, Christine; Brown, Steven A.

doi:10.1007/978-1-4614-3903-5_11

Cited by 2 publications

(2 citation statements)

References 98 publications

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“…This evidence was recently summarized elsewhere [10]. Here, we will focus on the potential roles for adenosine and adenosine receptors in regulating the homeostatic facet of sleep and metabolism.…”

Section: Wakefulness and Sleep Are Regulated By Circadian And Homeostmentioning

confidence: 96%

Sleep Homeostasis, Metabolism, and Adenosine

Holst

Landolt

2015

Curr Sleep Medicine Rep

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Sleep is an integral and constitutive part of life, invariably observed in animals with even a simple nervous system. Importantly, sleep is an active and highly regulated state. Sleep propensity or sleep need and its best established biological marker, electroencephalographic (EEG) slow-wave (or delta) activity, is tightly associated to prior wakefulness and sleep and is homeostatically regulated. Sleep need may be considered an essential aspect of life, just like feeding, drinking, and procreation. Sleep, therefore, likely developed in a primordial state of evolution and should either aid or, at least, not interfere with other essential biological aspects of life such as metabolisms and reproduction. Consistent with this view, brain circuitries regulating sleep need, metabolism, and reward appear to involve the basal ganglia and are tightly linked. They may sense changes in the organism's major cellular energy store, adenosine-tri-phosphate (ATP), and its derivative adenosine, and act in concert with other important neuromodulatory systems including dopamine, glutamate, and hypocretin.

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Section: Wakefulness and Sleep Are Regulated By Circadian And Homeostmentioning

confidence: 96%

Sleep Homeostasis, Metabolism, and Adenosine

Holst

Landolt

2015

Curr Sleep Medicine Rep

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show abstract

“…AMP kinase, a cellular energy sensor that relies on AMP, can phosphorylate multiple clock proteins, including Sirt 1, thereby upregulating this enzyme and affecting downstream pathways. As mentioned earlier, the function of Sirt 1 is also influenced by NAD+ cofactor levels, which are regulated by both circadian and metabolic processes [92]. The neuromodulatory role of adenosine and its receptors has been observed in various neurodegenerative conditions, including Alzheimer's disease (AD) [93].…”

Section: Adenosinementioning

confidence: 99%

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2024

GJAGR

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Adenosine and Other Purinergic Products in Circadian Timing

Cited by 2 publications

References 98 publications

Sleep Homeostasis, Metabolism, and Adenosine

Sleep Homeostasis, Metabolism, and Adenosine

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