Adenosine bronchoprovocation: a promising marker of allergic inflammation in asthma?

Polosa, Riccardo; Holgate, Stephen T.

doi:10.1136/thx.52.10.919

Cited by 95 publications

(74 citation statements)

References 51 publications

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“…Adenosine has been suggested to play a role in inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD) [1][2][3]. Elevated levels of adenosine have been measured in the airway lining fluid of patients with asthma and COPD when compared to normal controls [4].…”

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confidence: 99%

Adenosine-receptor subtypes: their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease

2002

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Adenosine-receptor subtypes: their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease. R. Polosa. #ERS Journals Ltd 2002. ABSTRACT: Adenosine administration by inhalation elicits concentration-related bronchoconstriction in subjects with asthma and chronic obstructive pulmonary disease (COPD). The mechanisms of adenosine-induced bronchoconstriction appear to involve a selective interaction with activated mast cells with subsequent release of preformed and newly-formed mediators. Further evidence linking adenosine signalling to asthma and COPD comes from the finding that many cell types that play important roles in the exacerbation of these conditions express adenosine receptors and demonstrate relevant effects through stimulation of these receptors.Therefore, blockade of these receptors may be a valuable approach to the treatment of asthma and chronic obstructive pulmonary disease. Promising adenosine-receptor targets for novel therapeutics of asthma and chronic obstructive pulmonary disease have recently been identified in a number of inflammatory cell types, including mast cells, eosinophils, lymphocytes, neutrophils, and macrophages. The recent characterisation of the A 2B receptors indicates the human lung mast cell as one of the most strategic cellular targets. Eur Respir J 2002; 20: 488-496.

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confidence: 99%

Adenosine-receptor subtypes: their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease

2002

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“…Because both the release and indirect action of adenosine have been shown to be related to the number and/or activation of "primed" mast cells and other inflammatory cells present in the airways this could explain the observed relationships [1][2][3][4][5]. It also seems to be obvious that the enhanced level of adenosine in the airways would lead to potentiated airway obstruction provoked by diverse bronchoconstrictor agents in asthma [6,7].…”

Section: From the Authorsmentioning

confidence: 94%

“…Natural exposure to aeroallergens is likely to modulate the level of airway inflammation not only in asthma but also in hay fever patients. We have repeatedly shown that nonasthmatic individuals with allergic rhinitis also exhibit features of active inflammation in the lower airways which deteriorates during natural allergen exposure [4,5].…”

Section: To the Editormentioning

confidence: 99%

“…Heat transfer in the airways in the context of respiratory disease was studied by WALKER et al [2] in 1961, and since in COPD [3], cystic fibrosis [4] and thermally induced asthma [5]. There is still controversy over the relative roles of the upper airway, bronchial circulation and pulmonary circulation in airway heat exchange.…”

Section: Exhaled Breath Temperature In Airways Diseasementioning

confidence: 99%

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et al. 2003

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“…In the respiratory system, the bronchoconstrictor effects of adenosine are well known [7]. Thus, ADA polymorphism could modulate adenosine receptor activity in the respiratory tract with effects on the signal transduction pathway of adenosine and other mediators.…”

Section: To the Editormentioning

confidence: 99%

Cooperative effect of adenosine deaminase and ABO-secretor genetic complex on susceptibility to childhood asthma

Bottini¹,

Ronchetti²,

Gloria‐Bottini³

2002

Eur Respir J

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Adenosine bronchoprovocation: a promising marker of allergic inflammation in asthma?

Cited by 95 publications

References 51 publications

Adenosine-receptor subtypes: their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease

Adenosine-receptor subtypes: their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease

From the Authors

Cooperative effect of adenosine deaminase and ABO-secretor genetic complex on susceptibility to childhood asthma

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