Adenosine deaminase activity in patients with the intestinal type of gastric carcinoma

Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in prostate cancer patients: Influence of Gleason score, treatment and bone metastasis

“…Our results are in agreement with other authors that showed low ADA activity values in tumor tissues or lymphocytes from cancer patients [22,23,38]. On the other hand, in some studies ADA activity was found to be increased in cancerous tissue, suggesting that increased ADA activity may be a compensatory mechanism against toxic accumulation of its substrates [39].…”

“…Due to the irreversibility of the reaction catalyzed by ADA, the reaction appears to be one of the ratelimiting steps in adenosine degradation [20]. In several studies, ADA activities have presented controversial results regarding cancerous tissues and cells [21][22][23].…”

Diagnostic Utility of Adenosine Deaminase in Serum and Bronchoalveolar Lavage Fluid for Screening Lung Cancer in Western Iran

“…Several studies investigated the change of the adenosine deaminase activity in various cancerous patients. Many authors have shown the increase of serum tADA activity in these patients (4,7,(23)(24)(25)(26). Adapted to previous data, our results showed higher ADA activity in patients with lung cancer compared to controls.…”

Chemotherapy Effects on the Activities of Some Purine Metabolic Enzymes in Sera of Ovarian Cancer Patients

“…The increase in ADA activity that was observed in this study (Table 1) in sera of patients with malignant ovarian tumors can be regarded as a local activation of cellular immune response [24,25,26].…”