Adenosine Deaminase as a Useful Biomarker for Diagnosis and Monitoring of Inflammatory Bowel Disease

Yordanova, M.; Gerova, Daniela; Atanassova, Antonia; Galunska, Bistra

doi:10.7754/clin.lab.2019.191124

Cited by 9 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…29 Serum adenosine deaminase levels have been found to be increased in patients with Inflammatory bowel disease, and serum adenosine deaminase is a useful biomarker for assessment of intestinal inflammation. 30 It is well established in the literature that a significantly correlation between serum adenosine deaminase and C-reactive protein has been suggested in patients with chagas disease, 31 supporting the view, our data also showed the link between serum adenosine deaminase and high-sensitivity C-reactive protein in T2DM patients.…”

Section: Discussionsupporting

confidence: 88%

Serum Adenosine Deaminase as a Useful Marker to Estimate Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients

Zhou

et al. 2021

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

We investigated the association between serum adenosine deaminase and coronary artery calcification (CAC) in type 2 diabetes mellitus (T2DM) patients. The cross-sectional study included 459 patients with T2DM, the clinical and laboratory tests were performed, and all T2DM patients were separated into the 3 groups based on the tertile of serum adenosine deaminase levels. In the baseline data, the CAC score had statistically significant differences between the 3 groups (p < 0.001). Serum adenosine deaminase levels were positively correlated with CAC score in T2DM patients (r = 0.355, p < 0.001). The results of multiple linear regression analysis showed that serum adenosine deaminase was independent positively correlated with CAC score in T2DM patients (r = 0.255, p < 0.001). Receiver-operating characteristic curve analysis showed that area under curve was 0.750 to identify T2DM patients with CAC. Serum adenosine deaminase levels are correlated with CAC scores in T2DM patients, clinically, serum adenosine deaminase should be considered as an underlying marker to determine the severity of atherosclerosis in T2DM patients.

show abstract

Section: Discussionsupporting

confidence: 88%

Serum Adenosine Deaminase as a Useful Marker to Estimate Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients

Zhou

et al. 2021

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

show abstract

“…In addition to regulating adenosine concentration by catalyzing the irreversible deamination of adenosine to inosine ( 5 ), ADA is also essential for the differentiation and maturation of T lymphocytes and is a general marker of cellular immunity ( 6 ). In some autoimmune diseases, such as psoriasis ( 7 ), autoimmune hepatitis ( 8 ), inflammatory bowel disease ( 9 ), and rheumatic disease ( 10 ), high serum concentrations of ADA were observed. Meanwhile, increased ADA activity was also observed in the peripheral blood leucocytes of patients with GD ( 11 ) and monocytes of patients with Hashimoto disease ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

The association between serum adenosine deaminase levels and Graves’ disease

Liu

et al. 2021

Endocrine Connections

View full text Add to dashboard Cite

Background: Adenosine deaminase (ADA) is essential for the differentiation and maturation of lymphocytes, while lymphocytes infiltration in thyroid tissue is a vital pathological feature of Graves' disease (GD). The aim of the present study was to compare the concentration of ADA between healthy controls (HC) and patients with GD, and evaluate the association between ADA and GD. Methods: A total of 112 GD patients and 77 matched HC were enrolled in this study. Each participant was examined for thyroid hormones and autoantibodies, ADA concentration and thyroid ultrasonography. Results: Serum ADA levels in GD patients were significantly higher than that in HC subgroup (p < 0.001). In GD patients, serum ADA levels were positively associated with serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), thyroid-stimulating hormone receptor antibody (TRAb) levels and total thyroid gland volume (thyroid VolT), and negatively associated with serum thyroid-stimulating hormone receptor (TSH) levels (all p < 0.05). There were no similar correlations in HC subgroup. Multiple linear regression analysis suggested that serum TSH, FT3 and ADA levels played an important role in serum TRAb levels. Conclusions: Our results demonstrated that serum ADA levels were closely associated with GD.

show abstract

“…Previous studies have proven that the defects in insulin action of T-lymphocyte may play an important role in inappropriate immune responses in T2D [ 24 ]. ADA is more active in T-lymphocyte than in B-lymphocyte, and it plays an important role in lymphocyte proliferation, differentiation, and maturation [ 25 , 26 ]. A small-scale study by Khemka et al [ 17 ] demonstrate that serum ADA levels were significantly higher in nonobese T2D subjects than in healthy controls, and were positively correlation with FPG in these T2D subjects.…”

Section: Discussionmentioning

confidence: 99%

Inverse relationship between serum adenosine deaminase levels and islet beta cell function in patients with type 2 diabetes

Cao

Wang

et al. 2021

Diabetol Metab Syndr

View full text Add to dashboard Cite

Objective Type 2 diabetes (T2D) is a chronic low-grade inflammatory disease, which characterized by islet beta cell dysfunction. Serum adenosine deaminase (ADA) is an important enzyme that regulates the biological activity of insulin, and its levels are greatly increased in inflammatory diseases with insulin resistance. The present study was designed to explore the relationship between serum ADA levels and islet beta cell function in patients with T2D. Methods This cross-sectional study recruited 1573 patients with T2D from the Endocrinology Department of the Affiliated Hospital 2 of Nantong University between 2015 and 2018. All participants were received serum ADA test and oral glucose tolerance test (OGTT). Insulin sensitivity index (assessed by Matsuda index using C-peptide, ISIM-cp), insulin secretion index (assessed by ratio of area under the C-peptide curve to glucose curve, AUCcp/glu) and islet beta cell function (assessed by insulin secretion-sensitivity index 2 using C-peptide, ISSI2cp) were derived from OGTT. And other clinical parameters, such as HbA1c, were also collected. Results It was showed that HbA1c was significantly increased, while ISIM-cp, AUCcp/glu and ISSI2cp significantly decreased, across ascending quartiles of serum ADA levels. Moreover, serum ADA levels were negatively correlated with ISSI2cp (r = − 0.267, p < 0.001). Furthermore, after adjusting for other clinical parameters by multiple linear regression analysis, serum ADA levels were still independently associated with ISSI2cp (β = − 0.125, t = − 5.397, p < 0.001, adjusted R2 = 0.459). Conclusions Serum ADA levels are independently associated with islet beta cell function in patients with T2D.

show abstract

Adenosine Deaminase as a Useful Biomarker for Diagnosis and Monitoring of Inflammatory Bowel Disease

Cited by 9 publications

References 0 publications

Serum Adenosine Deaminase as a Useful Marker to Estimate Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients

Serum Adenosine Deaminase as a Useful Marker to Estimate Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients

The association between serum adenosine deaminase levels and Graves’ disease

Inverse relationship between serum adenosine deaminase levels and islet beta cell function in patients with type 2 diabetes

Contact Info

Product

Resources

About