2020
DOI: 10.1111/crj.13277
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Adenosine deaminase cutoff value when diagnosing tuberculous pleurisy in patients aged 40 years and older

Abstract: Introduction Tuberculous pleurisy (TBP) is one of the most common manifestations of extra‐pulmonary tuberculosis. In patients aged ≥40 years, a closed needle pleural biopsy is recommended with an adenosine deaminase (ADA) level of 40‐70 U/L. We aim to investigate whether the cutoff value of ADA and the cancer ratio in patients with TBP aged ≥40 years is different and determine the effects of both compounded biomarkers on diagnosing TBP. Materials and Methods Between 2009 and 2016, the ADA levels were measured … Show more

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Cited by 3 publications
(3 citation statements)
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“…The analysis found that the ADA level [cut-off value 40 U/L, sensitivity 70%] was lower in people over 40, which was close to the results reported by Arpinar Yigitbas B 7 but lower than some previous studies, 12 , 27 which may be related to the fact that the previous literature did not classify ADA by age. Moreover, we included the complexity associated with the patient’s diagnosis requiring thoracoscopic biopsy to assist in the diagnosis.…”
Section: Discussionsupporting
confidence: 85%
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“…The analysis found that the ADA level [cut-off value 40 U/L, sensitivity 70%] was lower in people over 40, which was close to the results reported by Arpinar Yigitbas B 7 but lower than some previous studies, 12 , 27 which may be related to the fact that the previous literature did not classify ADA by age. Moreover, we included the complexity associated with the patient’s diagnosis requiring thoracoscopic biopsy to assist in the diagnosis.…”
Section: Discussionsupporting
confidence: 85%
“… 6 It is widely used in TPE diagnosis because of its economic detection, convenience, and availability. 7–9 However, ADA can also increase parapneumonic effusions (mainly in those complicated and empyema) along with some cases of malignant pleural effusions (mostly lymphomas, and by far less frequently other malignancies) and systemic lupus erythematosus (SLE). 6 Diagnostic accuracy is affected significantly by aging.…”
Section: Introductionmentioning
confidence: 99%
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