Adenosine Deaminase Genetic Polymorphism and Coronary Artery Disease

Banci, Maria; Saccucci, Patrizia; D’Annibale, Federica; Dofcaci, Alessandro; Trionfera, Gianfranco; Magrini, Andrea; Bottini, Nunzio; Bottini, E.; Gloria‐Bottini, F.

doi:10.1159/000139954

Cited by 9 publications

(4 citation statements)

References 4 publications

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“…We have confirmed in males this association [2]. An inverse relationship between birth weigh (BW) and CAD is well documented, and we have confirmed this association in females [3].…”

Section: Introductionsupporting

confidence: 77%

Coronary Artery Disease: A Study on the Joint Role of Birth Weight, Adenosine Deaminase, and Gender

Gloria‐Bottini

Banci

Saccucci

et al. 2009

Cardiology Research and Practice

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An inverse relationship between birth weight and coronary artery diseases is well documented but it remains unclear which exposure in early life might underlie such association. Recently it has been reported an association between adenosine deaminase genetic polymorphism and coronary artery diseases. Gender differences in the degree of this association have been also observed. These observations prompted us to study the possible joint effects of BW, ADA, and gender on the susceptibility to coronary artery diseases. 222 subjects admitted to hospital for nonfatal coronary artery diseases, and 762 healthy consecutive newborns were studied. ADA genotypes were determined by DNA analysis. A highly significant complex relationship has emerged among ADA, birth weight, and gender concerning their role on susceptibility to coronary artery diseases in adult life. Odds ratio analysis suggests that low birth weight is more important in females than in males. ADA∗2 allele appears protective in males, while in females such effect is obscured by birth weight.

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“…We have confirmed in males this association [2]. An inverse relationship between birth weigh (BW) and CAD is well documented, and we have confirmed this association in females [3].…”

Section: Introductionsupporting

confidence: 77%

Coronary Artery Disease: A Study on the Joint Role of Birth Weight, Adenosine Deaminase, and Gender

Gloria‐Bottini

Banci

Saccucci

et al. 2009

Cardiology Research and Practice

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“…Obesity, dyslipidemia, hypertension, smoking habit, age and sex did not show a statistically significant effect on the association between PTPN22 and CAD. ACP1 and adenosine deaminase locus 1 genetic polymorphisms previously shown to be associated with CAD [6,7,8] have been considered. A statistically significant effect has been observed for ACP1 only.…”

Section: Resultsmentioning

confidence: 99%

Atherosclerosis and PTPN22: A Study in Coronary Artery Disease

et al. 2011

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Objectives: Recently, it has been shown that PTPN22 genetic polymorphism is associated with phenotypes related to the risk of atherosclerosis. In the present note, we have searched for a possible association of PTPN22 polymorphism with coronary artery disease (CAD). Methods: One hundred and thirty-four non-diabetic subjects admitted to hospital for CAD and 174 healthy subjects (blood donors) were studied. PTPN22 genotypes were determined by DNA analysis. Statistical analyses were performed by SPSS programs. Results: In CAD patients, the proportion of carriers of the *T allele of PTPN22 is significantly higher compared to healthy controls (OR 2.66; 95% CI 1.07–6.72). Conclusions: The present observation confirms the association of PTPN22 phenotype with atherosclerosis and suggests a role of immune mechanism in the pathogenesis of CAD.

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“…An association between Adenosine Deaminase locus 1 (ADA 1 ) and Coronary Artery Disease (CAD) has been described in the Polish population [1] and confirmed in the Italian population [2]. In Italy, however, a significant association was found in males only.…”

Section: Introductionmentioning

confidence: 92%

The association of adenosine deaminase with coronary artery disease: Effect of gender and diabetes

Gloria‐Bottini

Safranow²,

Banci³

et al. 2013

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An association between ADA₁ and Coronary Artery Disease (CAD) has been observed in Polish and in Italian populations but in Italian population the association was present in males only. In order to enlighten these differences we have carried out a collaborative study in the two populations. In Italy 215 subjects admitted to the Hospital for CAD, 275 subjects with Type 2 Diabetes (T2D) without CAD and 398 healthy new-borns were studied. In Poland 173 subjects with CAD and 200 healthy newborns were studied. Written informed consent was obtained from all subjects or from their mothers to participate to the study that was approved by the I.R.B. ADA₁ polymorphism was determined by DNA analysis. Three way contingency table analysis was performed by a log linear model. The association between CAD and ADA₁is present in non diabetic male subjects only: OR = 0.195, p = 0.007 in the Italian population and OR = 0.163, p = 0.004 in the Polish population. The data suggest a significant role of immunological mechanisms in the pathogenesis of CAD without diabetes. Gender differences in immune diseases could explain the lack of association in females.

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Adenosine Deaminase Genetic Polymorphism and Coronary Artery Disease

Cited by 9 publications

References 4 publications

Coronary Artery Disease: A Study on the Joint Role of Birth Weight, Adenosine Deaminase, and Gender

Coronary Artery Disease: A Study on the Joint Role of Birth Weight, Adenosine Deaminase, and Gender

Atherosclerosis and PTPN22: A Study in Coronary Artery Disease

The association of adenosine deaminase with coronary artery disease: Effect of gender and diabetes

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