Adenosine in the lateral hypothalamus/perifornical area does not participate on the CO2 chemoreflex

Rodrigues, Laísa Taís Cabral; Salata, Bruno; Horta-Júnior, José de Anchieta C.; Gargaglioni, Luciane H.; Dias, Mirela Barros

doi:10.1016/j.resp.2020.103368

Cited by 1 publication

(1 citation statement)

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“…For LC surgeries, the coordinates were 3.4 mm caudal to lambda, 1.3 mm lateral to midline and 7.4 mm below the bone surface, with an inclination of vertical stereotaxic bar at 15 • . These coordinates were adapted from Paxinos and Watson (2014) and based on previous studies (Rodrigues et al, 2019(Rodrigues et al, , 2020Silva et al, 2017). Different animals were used for LHA and LC cannulation.…”

Section: Surgerymentioning

confidence: 99%

Melanin‐concentrating hormone regulates the hypercapnic chemoreflex by acting in the lateral hypothalamic area

Rodrigues

Patrone

Gargaglioni

et al. 2022

Experimental Physiology

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Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide involved in a broad range of homeostatic functions including regulation of the hypercapnic chemoreflex. We evaluated whether MCH modulates the hypercapnic ventilatory response by acting in the lateral hypothalamic area (LHA) and/or in the locus coeruleus (LC). Here, we measured pulmonary ventilation ( VE ), body temperature, electroencephalogram (EEG) and electromyogram (EMG) of unanaesthetized adult male Wistar rats before and after microinjection of MCH (0.4 mM) or MCH receptor 1 (MCH1-R) antagonist (SNAP-94847; 63 mM) into the LHA and LC, in room air and 7% CO 2 conditions during wakefulness and sleep in the dark and light periods. MCH intra-LHA caused a decreased CO 2 ventilatory response during wakefulness and sleep in the light period, while SNAP-94847 intra-LHA increased this response, during wakefulness in the light period. In the LC, MCH or the MCH1-R antagonist caused no change in the hypercapnic ventilatory response. Our results suggest that MCH, in the LHA, exerts an inhibitory modulation of the hypercapnic ventilatory response during the light-inactive period in rats.

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