Adenosine phosphorylase and other enzymes of purine salvage in Pulmonata snails and their Trematoda parasites

Role of the phosphorolysis of deoxyadenosine in the cytotoxic effect of the combination of deoxyadenosine and deoxycoformycin on a human colon carcinoma cell line (LoVo)

“…In mammalian tissues, the existence of this activity appears to be a novelty because its presence has been reported in several biologic sources [Jensen, 1978;Trembacz and Jezewska, 1994], however, with the only exception of an adenosine phosphorylase activity described in Sarcoma 180 cells and rat liver [Divekar, 1976], not in mammals. Although the phosphorolysis of dAdo appears to be a secondary metabolic pathway in LoVo cells when the deamination process is operating, it becomes relevant in the presence of dCF.…”