Adenosine Signaling in Anxiety

Ruby, Christina L.; Adams, Chelsea A.; Mrazek, David A.; Choi, Doo Sup

doi:10.5772/19423

Anxiety Disorders 2011

DOI: 10.5772/19423

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Adenosine Signaling in Anxiety

Christina L. Ruby¹,

Chelsea A. Adams²,

David A. Mrazek³

et al.

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Cited by 2 publications

References 88 publications

(108 reference statements)

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Non-mammalian models in behavioral neuroscience: consequences for biological psychiatry

Maximino

Silva

et al. 2015

Front. Behav. Neurosci.

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Current models in biological psychiatry focus on a handful of model species, and the majority of work relies on data generated in rodents. However, in the same sense that a comparative approach to neuroanatomy allows for the identification of patterns of brain organization, the inclusion of other species and an adoption of comparative viewpoints in behavioral neuroscience could also lead to increases in knowledge relevant to biological psychiatry. Specifically, this approach could help to identify conserved features of brain structure and behavior, as well as to understand how variation in gene expression or developmental trajectories relates to variation in brain and behavior pertinent to psychiatric disorders. To achieve this goal, the current focus on mammalian species must be expanded to include other species, including non-mammalian taxa. In this article, we review behavioral neuroscientific experiments in non-mammalian species, including traditional “model organisms” (zebrafish and Drosophila) as well as in other species which can be used as “reference.” The application of these domains in biological psychiatry and their translational relevance is considered.

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Non-mammalian models in behavioral neuroscience: consequences for biological psychiatry

Maximino

Silva

et al. 2015

Front. Behav. Neurosci.

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Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression

2018

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Major depressive disorder is one of the most common and debilitating psychiatric disorders. Some of the motivational symptoms of depression, such anergia (lack of self-reported energy) and fatigue are relatively resistant to traditional treatments such as serotonin uptake inhibitors. Thus, new pharmacological targets are being investigated. Epidemiological data suggest that caffeine consumption can have an impact on aspects of depressive symptomatology. Caffeine is a non-selective adenosine antagonist for A1/A2A receptors, and has been demonstrated to modulate behavior in classical animal models of depression. Moreover, selective adenosine receptor antagonists are being assessed for their antidepressant effects in animal studies. This review focuses on how caffeine and selective adenosine antagonists can improve different aspects of depression in humans, as well as in animal models. The effects on motivational symptoms of depression such as anergia, fatigue, and psychomotor slowing receive particular attention. Thus, the ability of adenosine receptor antagonists to reverse the anergia induced by dopamine antagonism or depletion is of special interest. In conclusion, although further studies are needed, it appears that caffeine and selective adenosine receptor antagonists could be therapeutic agents for the treatment of motivational dysfunction in depression.

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Adenosine Signaling in Anxiety

Cited by 2 publications

References 88 publications

Non-mammalian models in behavioral neuroscience: consequences for biological psychiatry

Non-mammalian models in behavioral neuroscience: consequences for biological psychiatry

Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression

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