2010
DOI: 10.1016/j.bbrc.2010.01.023
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Adenosine up-regulates vascular endothelial growth factor in human macrophages

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Cited by 57 publications
(56 citation statements)
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“…Experimentally we have demonstrated that dipyridamole significantly restores hippocampally based spatial memory (Melani et al 2010) and has a protective effect on hippocampal CA1pyramidal neurons (Lana et al 2014) 90 days after 2VO. The increases of extracellular adenosine (Figueredo et al 1999), together with increased VEGF production (Ernens et al 2010), and the potentiation of the NO system (Aktas et al 2003;Venkatesh et al 2010) help explaining the protecting effect of dipyridamole in this rat model of hypoperfusion. Dipyridamole has a positive effect on blood flow and angiogenesis through the nitrite/NO endocrine system (Venkatesh et al 2010), increases NO levels and decreases superoxide formation both in ischemic and non-ischemic animals (Pattillo et al 2011), and has pleiotropic pharmacological effects, such as antioxidant and antiinflammatory proprieties (Blake 2004;Eisert 2002;Hsieh et al 2010;Riksen et al 2005).…”
Section: Discussionmentioning
confidence: 93%
“…Experimentally we have demonstrated that dipyridamole significantly restores hippocampally based spatial memory (Melani et al 2010) and has a protective effect on hippocampal CA1pyramidal neurons (Lana et al 2014) 90 days after 2VO. The increases of extracellular adenosine (Figueredo et al 1999), together with increased VEGF production (Ernens et al 2010), and the potentiation of the NO system (Aktas et al 2003;Venkatesh et al 2010) help explaining the protecting effect of dipyridamole in this rat model of hypoperfusion. Dipyridamole has a positive effect on blood flow and angiogenesis through the nitrite/NO endocrine system (Venkatesh et al 2010), increases NO levels and decreases superoxide formation both in ischemic and non-ischemic animals (Pattillo et al 2011), and has pleiotropic pharmacological effects, such as antioxidant and antiinflammatory proprieties (Blake 2004;Eisert 2002;Hsieh et al 2010;Riksen et al 2005).…”
Section: Discussionmentioning
confidence: 93%
“…3,10 Several studies also support the idea that adenosine stimulates the production of vascular endothelial growth factor (VEGF) and therefore supports tumor angiogenesis. [11][12][13] Adenosine in the tumor milieu is generated from extracellular nucleotides by ectonucleotidases such as CD39 and CD73. CD39 catalyzes the degradation of adenosine triphosphate (ATP) into AMP, and CD73 subsequently hydrolyzes AMP into adenosine.…”
Section: Introductionmentioning
confidence: 99%
“…Data are means ± SEM for six replicate determinations (n = [3][4][5] present, the A 3 receptor knockout has not been investigated for specific changes in the bone; however, no overt changes in phenotype have been noted [52]. Adenosine receptors display widespread expression and are involved in many biological processes including coronary vasodilation [53], VEGF production, angiogenesis [54,55] and nerve transmission [56]. Thus, it is possible that the changes in bone mass seen in the knockout mouse models are occurring indirectly via actions on other tissues.…”
Section: Discussionmentioning
confidence: 99%