Adenosine versus intravenous calcium channel antagonists for the treatment of supraventricular tachycardia in adults

Foo, Angeline

doi:10.1002/14651858.cd005154.pub2

Cited by 31 publications

(17 citation statements)

References 18 publications

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“…The prescriptive nature of the 2012 CPG (>30 min transport time to hospital) was contributing to the low administration rates of verapamil. The reversion rate of verapamil (where administered) was similar to previous findings, indicating that it is an effective pharmacological reversion agent . However, replacing verapamil with adenosine would provide improved opportunities to treat patients while also being supported in current Australian and international resuscitation council guidelines .…”

Section: Discussionsupporting

confidence: 83%

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Prehospital management of supraventricular tachycardia in Victoria, Australia: Epidemiology and effectiveness of therapies

Smith

Taylor

Morgans

et al. 2014

Emerg Medicine Australasia

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Section: Discussionsupporting

confidence: 83%

“…Although the VM was applied in less than one‐quarter of patients, reversion success (where attempted) exceeded that demonstrated in previous studies . The low rate of application, and the variation in number of attempts made are attributable to the 2012 Ambulance Victoria CPG A0403: Supraventricular Tachycardia (Fig.…”

Section: Discussionmentioning

confidence: 79%

Prehospital management of supraventricular tachycardia in Victoria, Australia: Epidemiology and effectiveness of therapies

Smith

Taylor

Morgans

et al. 2014

Emerg Medicine Australasia

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“…One LOE 5 randomized prospective adult study 345 and 1 LOE 5 meta-analysis, primarily involving adults but including some children, 346 demonstrated the effectiveness of verapamil and adenosine in treating SVT and highlighted the cost-effectiveness of verapamil over adenosine.…”

Section: Arrhythmia Therapypeds-030mentioning

confidence: 99%

Part 10: Pediatric Basic and Advanced Life Support

Kleinman

Caen

Chameides³

et al. 2010

Circulation

184

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Note From the Writing Group: Throughout this article, the reader will notice combinations of superscripted letters and numbers (eg, “Family Presence During ResuscitationPeds-003”). These callouts are hyperlinked to evidence-based worksheets, which were used in the development of this article. An appendix of worksheets, applicable to this article, is located at the end of the text. The worksheets are available in PDF format and are open access.

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“…Previous studies have demonstrated that both adenosine and verapamil have similar reversion effectiveness, (11,12,(15)(16)(17)(18)(19) yet these pre-hospital studies reported opposing views on reversion effectiveness between the two pharmacological agents. It is likely that the study-specific treatment regimen affected these results, with the use of medical oversight through authority to intervene via telemetry also influencing both intervention rate and reversion effectiveness as not all patients were treated within the study sample.…”

Section: Discussionmentioning

confidence: 96%

“…The primary pharmacological interventions for SVT are verapamil (a calcium channel blocking agent), and adenosine (a naturally occurring purine nucleoside which acts to inhibit sodium channels) (11).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and Safety of Paramedic Administration of Verapamil and Adenosine for the Treatment of Supraventricular Tachycardia: A Review of the Literature

Smith

2014

Australasian Journal of Paramedicine

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AbstractIntroductionAdenosine and verapamil are the most commonly used pharmacological agents to treat supraventricular tachycardia (SVT). This review aims to identify the effectiveness and safety of pre-hospital use of adenosine and verapamil by paramedics.MethodsA comprehensive electronic literature search was conducted. Studies of pre-hospital comparative effectiveness of adenosine and verapamil were included for further analysis. Studies where individual effectiveness of either verapamil or adenosine was reported in either the medical or pre-hospital setting were excluded. Animal studies and those articles unavailable in English were also excluded.ResultsTwo pre-hospital studies were identified. Verapamil demonstrated greater reversion effectiveness across both studies, with side effects more commonly reported in the adenosine arm of each. The duration and severity of side effects resulting from verapamil administration was greater than that of adenosine. Paramedic electrocardiogram (ECG) interpretation was questionable, resulting in a number of errors across both studies.ConclusionAvailable studies report that verapamil is more effective for pre-hospital SVT reversion. Effective pre-hospital drug therapy for SVT must incorporate a measure of patient impact with regard to severity, duration and interventions required to correcting adverse effects. A larger contemporary study is required to further evidence paramedic use of pharmacological agents to treat SVT. Paramedic ECG interpretation is a key factor influencing correct treatment, and adequate education must form the basis of pre-hospital guidelines for SVT management.

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Adenosine versus intravenous calcium channel antagonists for the treatment of supraventricular tachycardia in adults

Cited by 31 publications

References 18 publications

Prehospital management of supraventricular tachycardia in Victoria, Australia: Epidemiology and effectiveness of therapies

Prehospital management of supraventricular tachycardia in Victoria, Australia: Epidemiology and effectiveness of therapies

Part 10: Pediatric Basic and Advanced Life Support

Effectiveness and Safety of Paramedic Administration of Verapamil and Adenosine for the Treatment of Supraventricular Tachycardia: A Review of the Literature

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