Adenosquamous Carcinoma of Ampulla of Vater—a Rare Entity

Maji, Suvendu; Jha, Jayesh Kumar; Chaturvedi, Vikram

doi:10.1007/s13193-021-01327-3

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…The multivariate analysis showed that age, ethnicity, adenosquamous histology, differentiation grade, and lymphovascular invasion were independent prognostic factors for OS (Murimwa et al, 2021). ASCs of the ampulla of Vater have also been described in the literature, confirming its more aggressive behavior, with a worse prognosis than ampullary adenocarcinomas mainly due to the increased frequency of lymphovascular invasion and distant metastases (Maji et al, 2021).…”

Section: Adenosquamous Carcinoma Of Gallbladdermentioning

confidence: 83%

Rare histotypes of epithelial biliary tract tumors: A literature review

Sapuppo

Brunetti

Tessitore

et al. 2023

Critical Reviews in Oncology/Hematology

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Section: Adenosquamous Carcinoma Of Gallbladdermentioning

confidence: 83%

Rare histotypes of epithelial biliary tract tumors: A literature review

Sapuppo

Brunetti

Tessitore

et al. 2023

Critical Reviews in Oncology/Hematology

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“…The incidence of duodenal carcinoma has recently increased due to the widespread use and development of endoscopic examination [ 1 , 2 ]. Although most duodenal carcinomas are adenocarcinomas, a small number of cases have been reported of adenosquamous carcinoma (ASC), characterized by variable combinations of two malignant components: adenocarcinoma and squamous cell carcinoma [ 3 , 4 ]. Non-ampullary duodenal adenosquamous carcinoma (NADASC) is rare.…”

Section: Introductionmentioning

confidence: 99%

A case of non-ampullary duodenal adenosquamous carcinoma with successful emergency pancreaticoduodenectomy for gastrointestinal hemorrhage

Miyama,

Chikaishi,

Kobayashi

et al. 2023

surg case rep

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Background Although most duodenal carcinomas are pathological adenocarcinomas, a small number of cases have been reported of adenosquamous carcinoma, characterized by variable combinations of two malignant components: adenocarcinoma and squamous cell carcinoma. However, owing to the small number of cases of non-ampullary duodenal adenosquamous carcinoma, there have been no reported cases of emergency pancreaticoduodenectomy for gastrointestinal hemorrhage due to non-ampullary duodenal adenosquamous carcinoma. Case presentation A 66-year-old Japanese male presented to the referring hospital with a chief complaint of abdominal pain, diarrhea, and dark urine that had persisted for 1 month. The patient was referred to our hospital because of liver dysfunction on a blood examination. Laboratory results of the blood on the day of admission showed that total and direct bilirubin levels (12.0 mg/dl and 9.6 mg/dl) were markedly increased. An endoscopic retrograde biliary drainage tube was inserted for the treatment of obstructive jaundice, and imaging studies were continuously performed. Contrast-enhanced computed tomography and endoscopy revealed an ill-defined lesion involving the second portion of the duodenum, predominantly along the medial wall, and measuring 60 mm in diameter. No metastases were observed by positron emission tomography. Pancreaticoduodenectomy was planned based on the pathological findings of poorly differentiated adenocarcinoma. However, 2 days before the scheduled surgery, the patient experienced hemorrhagic shock with melena. Owing to poor hemostasis after endoscopic treatment and poor control of hemodynamic circulation despite blood transfusion, radiological embolization and hemostasis were attempted but were incomplete. An emergency pancreaticoduodenectomy was performed after embolizing the route from the gastroduodenal artery and pseudoaneurysm area to reduce bleeding. The operation was completed using an anterior approach without Kocherization or tunneling due to the huge tumor. The operation time was 4 h and 32 min, and blood loss was 595 mL The pathological diagnosis was adenosquamous carcinoma. The postoperative course was uneventful with 17 day hospital stay and the patient is currently well, with no signs of recurrence 9 months after surgery. Conclusions This report presents an extremely rare case of successful emergency pancreaticoduodenectomy for gastrointestinal hemorrhage caused by non-ampullary duodenal adenosquamous carcinoma.

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Adenosquamous Carcinoma of Ampulla of Vater—a Rare Entity

Cited by 2 publications

References 8 publications

Rare histotypes of epithelial biliary tract tumors: A literature review

Rare histotypes of epithelial biliary tract tumors: A literature review

A case of non-ampullary duodenal adenosquamous carcinoma with successful emergency pancreaticoduodenectomy for gastrointestinal hemorrhage

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