Adenosquamous carcinoma of the conjunctiva: A case report

Abstract

Adenosquamous carcinoma (ASC) is a rare form of malignancy which consists of two types of cell, including squamous cells and glandular-like cells. The current report presents the first known case of ASC in the conjunctiva and analyzes the histological findings. A 76-year-old female presented with right eyelid swelling in 2001. A right conjunctival tumor was noted and a biopsy was performed. Histologically, the tumor was diagnosed as a squamous cell carcinoma. The patient underwent radiotherapy, but the tumor rapidly relapsed. Subsequently, the patient underwent orbital exenteration. Histologically, the conjunctival tissues had been replaced with invasive tumor cells. A number of tumor cells demonstrated squamous differentiation with a keratinizing tendency, while other tumor cells exhibited mucin-producing activity with glandular formation. The conjunctival tumor was diagnosed as an ASC. At the time of writing, the patient is well without local recurrence or distant metastases. ASC typically exhibits aggressive biological behavior, and is associated with worse prognosis than conventional adenocarcinoma. Therefore, complete surgical excision is considered a key treatment for ASC of the conjunctiva.

Two rare cases of pancreatic adenosquamous carcinoma: A review of the literature with focus on radiologic findings

“…Imaging characteristics of PASC are nonspecific, but prior reports indicate a lobulated, infiltrative, predominantly cystic mass with rim-enhancement and central necrosis may be suggestive of this rare diagnosis—characteristics that are rarely seen with pancreatic adenocarcinoma [11], [12], [13], [14], [20], [21]. Additional findings such as portal vein thrombosis have also been described [12].…”

“…No specific imaging features distinguish PASC from adenocarcinoma, but several useful clues have been previously reported including an infiltrating round-lobulated mass, extensive central necrosis with ring-enhancement, location in the body or tail of the pancreas, or tumor thrombus in the portal venous system [11], [12], [13], [14]. Given its highly aggressive nature and dismal prognosis, accurate imaging diagnosis and determination of surgical resectability are of paramount importance, despite the rarity of this pancreatic carcinoma subtype.

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