Adenosquamous carcinoma of the jejunum

Wada, Takeshi; Mizuno, Kotaro; Itoh, Kazuyuki; Monoe, Takashi; Ando, Hakuji; Kondo, Yutaka; Tanaka, Hiroki; Ogawa, Kento; Kanai, Masashi; Joh, Takashi; Itoh, Makoto

doi:10.1007/s00535-002-1147-7

Cited by 8 publications

(15 citation statements)

References 12 publications

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“…However, in the jejunum and ileum, it is a curiosity. Only six cases have been documented in the English‐language medical literature 1–6 . A review of our archives found that the present case was the first in 50 years.…”

Section: Discussionmentioning

confidence: 81%

“…Adenosquamous carcinomas have been described in various organs, but are extremely rare in the small intestine. To date, only three jejunal and three ileal cases have been reported in the English‐langulage medical literature 1–6 . We present here a case of jejunal adenosquamous carcinoma in an 80‐year‐old woman, with a predominant squamous component throughout the tumor, and mesenteric metastasis from the adenocarcinoma element, and with foci of morphological transition from the glandular component to the squamous component.…”

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confidence: 94%

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Primary adenosquamous carcinoma of the jejunum

Wang

Gong

et al. 2005

Pathology International

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Adenosquamous carcinomas of the small intestine are extremely rare, with only three documented jejunal and three ileal cases being reported in the English-language medical literature. Presented herein is a case of primary jejunal adenosquamous carcinoma in an 80-year-old woman. The jejunal carcinoma consisted predominantly of a squamous component throughout the tumor but peritoneal nodules carrying metastases from the adenocarcinoma element were noted, making it the first case of jejunal adenosquamous carcinoma with metastases from the adenocarcinoma component. The finding that metastases could arise from the minor component of a jejunal adenosquamous carcinoma indicates that an accurate diagnosis must be based upon thorough examination of both the primary and the metastases, not just mesenteric nodule biopsy alone. Histological foci of closely intermingled squamous and glandular components with apparent morphological transition were noted, indicating the pathogenetic possibility that the squamous component might arise by transformation from the glandular element. The squamous component was strongly positive with immunostaining for p63 (nuclear staining) and for cytokeratin 10/13 (cytoplasmic staining), while the adenocarcinoma element was negative. The immunohistochemical results suggest that p63 and cytokeratin 10/13 might be useful in identifying squamous differentiation in jejunal carcinoma.

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Section: Discussionmentioning

confidence: 81%

mentioning

confidence: 94%

Primary adenosquamous carcinoma of the jejunum

Wang

Gong

et al. 2005

Pathology International

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“…In areas where glandular and squamous epithelia are normally juxtaposed, such as the esophago-gastric or the rectal-anal junction, it is considered that both adenocarcinoma and squamous carcinoma could occur independently and collide by chance. This scenario, however, does not seem to be applicable to the case described by Wada et al, 1 …”

mentioning

confidence: 51%

“…According to this concept, cancer behavior, including the determination of phenotype, is dependent on the noncancerous cells surrounding the cancer tissue. Therefore, in the case reported by Wada et al, 1 it can be considered that there might have been some alterations defining adenocarcinoma in the surrounding normal tissue, and subsequently the different phenotype, i.e., the squamous feature, appeared. All four of the above theories provide only speculative answers in this case, and we cannot resolve this question yet.…”

Section: In Terms Of Normal Intestinalmentioning

confidence: 94%

“…Thus, the squamous cell component is most likely to arise from adenocarcinoma at a later stage of tumor development. Based on these facts, it is natural to think that this process could also have happenned in the adenocarcinoma in the case described by Wada et al, 1 with the squamous component having been induced through the development of adenocarcinoma. This phenomenon can be understood as an instance of transdifferentiation, on which there has been a strong focus recently, with growing evidence of such phenomena.…”

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confidence: 93%

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How does adenosquamous carcinoma arise in the small intestine?

Teramoto

Kawamata

Fujimori

2003

Journal of Gastroenterology

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Intestinal obstruction caused by primary adenosquamous cell carcinoma of the small intestine: A case report and review of the literature

et al. 2018

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Primary adenosquamous cell carcinoma (ASCC) arising from the ileum is an exceptionally rare malignant neoplasm exhibiting mixed glandular and squamous differentiation. The clinicopathological characteristics of ASCC have not been clearly determined due to its rarity. We herein report a case of a 74-year-old man with a successfully treated ASCC of the ileum. The patient visited a medical clinic due to abdominal pain. Abdominal computed tomography imaging revealed an intestinal tumor in the ileum. Prior to undergoing capsule endoscopy, the patient complained of severe abdominal pain due to intestinal obstruction from the patency capsule and the tumor. Thus, the patient was referred to our hospital for emergency surgery. Upon relieving the obstruction by partial resection of the ileum, an impacted patency capsule with a tumor with ulceration was identified. On histological examination, the tumor consisted of malignant glandular and squamous cell elements. The postoperative course was uneventful, without complications. The patient subsequently received adjuvant chemotherapy with oxaliplatin and capecitabine for 6 months. The patient has no evidence of recurrence 20 months after surgery. To the best of our knowledge, only 8 cases of ASCC have been reported in the English literature to date. This case serves as an important reminder to consider small intestinal carcinoma, including ASCC, in the differential diagnosis of intestinal obstruction.

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Adenosquamous carcinoma of the jejunum

Cited by 8 publications

References 12 publications

Primary adenosquamous carcinoma of the jejunum

Primary adenosquamous carcinoma of the jejunum

How does adenosquamous carcinoma arise in the small intestine?

Intestinal obstruction caused by primary adenosquamous cell carcinoma of the small intestine: A case report and review of the literature

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