Adenosquamous carcinoma of the liver

Park, Shin Young; Jung, Eun Jung; Moon, Woo Sung

doi:10.3350/cmh.2012.18.3.326

Cited by 13 publications

(5 citation statements)

References 6 publications

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“…Adenosquamous cholangiocarcinoma (ASC) is a rare variant of cholangiocarcinoma, which was first described by Barr and Hancock in 1975 [11] and consists of malignant glandular and squamous components. Tumor cells have both mucin-producing glandular structures as in adenocarcinoma and irregularly shaped solid nests of polygonal cells with distinct cellular borders, eosinophilic cytoplasm, varying degrees of keratinization, and intercellular bridges as in squamous cell cancer [12][13] . Cholangiocarcinoma with squamous features have been previously described as ASC but also as mucoepidermoid carcinoma (mucus-producing cells and squamoid cells without keratin formation) and adenoacanthoma (squamous metaplasia) [6,14] .…”

Section: Discussionmentioning

confidence: 99%

Cholangiocarcinoma Presenting as Humoral Hypercalcemia of Malignancy: A Case Report and Literature Review

Erdinc¹,

Ramachandran²,

Yadav³

et al. 2019

Cureus

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Humoral hypercalcemia of malignancy (HHM) is most commonly encountered in squamous cell carcinoma (SCC) of different organs, and It is characterized by elevated parathyroid hormonerelated peptide (PTHrP) levels. It may be seen as a manifestation of cholangiocarcinoma (CCC) at presentation and later in the course of the disease. However, HHM due to intrahepatic cholangiocarcinoma is a rare association and is associated with a poor prognosis. We herein report a case of hypercalcemia presenting as the first manifestation of an underlying rare variant of intrahepatic cholangiocarcinoma. Our patient is a 57-year-old male who presented to the emergency room with severe symptoms of constipation and polyuria and was admitted to the hospital for symptomatic hypercalcemia. He was found to have a hypermetabolic 15 cm liver mass, abdominal lymph nodes on imaging, which was subsequently diagnosed as adenosquamous cholangiocarcinoma by liver biopsy. This necessitated an urgent inpatient treatment with gemcitabine/cisplatin combination chemotherapy to control the aggressive nature of the malignancy. However, he deteriorated and expired after three months of his diagnosis. Adenosquamous cholangiocarcinoma is a very rare variant of a liver tumor. It develops due to squamous metaplasia of an underlying cholangiocarcinoma and usually has aggressive clinicopathological features. HMM is a life-threatening, yet unrecognized, phenomenon of cholangiocarcinoma, which represents a poor prognostic marker. Prompt recognition of this complication is important for preventing serious complications associated with hypercalcemia and to improve the quality of life of these patients.

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Section: Discussionmentioning

confidence: 99%

Cholangiocarcinoma Presenting as Humoral Hypercalcemia of Malignancy: A Case Report and Literature Review

Erdinc¹,

Ramachandran²,

Yadav³

et al. 2019

Cureus

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“…Histologically, ASC exhibits two components: glandular (adenocarcinoma) and squamous (squamous cell carcinoma). The adenocarcinoma component is formed by variable-sized glandular structures containing intracellular and extracellular mucin, whereas the squamous cell carcinoma component is characterized by irregularly shaped solid and nests of polygonal cells with distinct cellular border, eosinophilic cytoplasm, varying degrees of keratinization, and intercellular bridges [ 2 , 6 ]. Cholangiocarcinoma with a squamous differentiation have been previously described as ASC, mucoepidermoid carcinoma, and adenoacanthoma [ 2 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…In Korea, 10 cases with primary hepatic ASC (including our case) have been reported ( Table 1 ) [ 6 , 11 - 18 ]. The mean age of these cases was 62.5±7.9 years and a male predominance was noted (M/F=7:3).…”

Section: Discussionmentioning

confidence: 99%

Primary adenosquamous carcinoma of the liver: a case report

Nam

Kim

2016

Clin Mol Hepatol

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Adenosquamous carcinoma of the liver is a rare variant of cholangiocarcinoma. It is known to be a highly aggressive tumor with a poor prognosis, but its pathogenesis remains unclear owing to limited data in the literature. We report a case of 56-year-old woman who presented with a 1-week history of epigastric pain. Magnetic resonance imaging revealed a 6.5-cm ill-defined mass with low signal intensity in the left lobe of the liver, which was suspicious of cholangiocarcinoma. The patient underwent left hemihepatectomy. Microscopically, the tumor consisted of malignant glandular and squamous components and staged as pT2aN1. Despite postoperative chemoradiation, the patient had recurrence 8 months after surgery.

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“…It rarely occurs in the bile duct, especially the intrahepatic bile duct 4 . ASC generally has a worse prognosis than common adenocarcinoma as it tends to present more invasive clinicopathological profile 5 . Early diagnosis of this rare condition allows the delivery of effective treatment and better outcomes.…”

Section: Figurementioning

confidence: 99%