Adenosquamous Carcinoma of the Skin

Fu, Jennifer; McCalmont, Tim; Yu, Siegrid S.

doi:10.1001/archdermatol.2009.218

Cited by 34 publications

(25 citation statements)

References 32 publications

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“…In the setting of composite tumors with squamous and glandular components, the differential diagnosis includes adenosquamous carcinoma (ASC), mucoepidermoid carcinoma (MEC), and BD with invasive sweat‐gland differentiation. The characteristics of these entities are summarized in Table . Largely on morphological grounds our case is best categorized as BD with invasive mucin‐secreting sweat gland differentiation and it corresponds with examples of such cases in the literature …”

Section: Discussionmentioning

confidence: 77%

Bowen disease with invasive mucin‐secreting sweat gland differentiation: Report of a case and review of the literature

et al. 2019

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Bowen disease (BD) with divergent adnexal differentiation is a rare composite cutaneous tumor featuring different phenotypic elements. Sebaceous, poroid and trichilemmal invasive components have been described in this setting and very infrequent reports of mucinous glandular differentiation are extant. Clinically, these tumors are not sufficiently distinctive to enable recognition without histopathological evaluation. From a microscopic perspective, care must be taken to exclude a collision tumor as well as other combined cutaneous neoplasms featuring squamous and glandular differentiation. Direct continuity between the two epithelial phenotypes helps to establish the correct diagnosis and generates interesting speculation about the pathogenesis of these and other epithelial skin tumors. We describe a case of BD in continuity with an invasive adenocarcinoma exhibiting mucinous sweat gland differentiation on the face of an elderly man. Details of the case are outlined with the objective of adding to a scant literature on this topic.

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Section: Discussionmentioning

confidence: 77%

Bowen disease with invasive mucin‐secreting sweat gland differentiation: Report of a case and review of the literature

et al. 2019

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“…1 Focal luminal positivity with CK7 may also be a more notable feature of ASC than SEDC. 1,[12][13][14][15] The rarity of MEC makes it difficult to analyse whether histological differences, such as squamoid differentiation, translate to specific clinical behaviour. This will become clearer as more cases are documented using the current nomenclature.…”

Section: Discussionmentioning

confidence: 99%

Squamoid eccrine ductal carcinoma of the scalp

et al. 2015

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“…They are currently regarded as being of low-grade malignant potential with significant risk for local recurrence and occasional involvement of locoregional lymph nodes. [6][7][8] Distant metastasis and disease-related mortality are, however, rare. The main treatment modalities are wide local excision and Mohs surgery.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Malignant Sweat Gland Tumors

Brenn

2015

Advances in Anatomic Pathology

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Sweat gland carcinomas represent an important and somewhat contentious group of tumors in diagnostic skin pathology. Although their overall incidence is rare, they show a wide range of histologic features, and reliable classification is often challenging. Awareness and recognition of these tumors is, however, important as they may be associated with significant morbidity and even disease-related mortality, especially if left untreated. According to their behavior, sweat gland carcinomas are traditionally separated into tumors with low-grade and high-grade malignant behavior. This article is aimed at increasing awareness and providing an overview of malignant sweat gland tumors with emphasis on recently reported and novel findings and diagnostically challenging and potentially underrecognized entities. It further aims to illustrate the wide morphologic range of these tumors and provides a discussion of the relevant immunohistochemistry, disease-specific behavior, and differential diagnosis.

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Adenosquamous Carcinoma of the Skin

Abstract: Background: Adenosquamous carcinoma is an uncommon cutaneous malignant neoplasm with mixed glandular and squamous differentiation and a propensity for aggressive clinical behavior.

Cited by 34 publications

References 32 publications

Bowen disease with invasive mucin‐secreting sweat gland differentiation: Report of a case and review of the literature

Bowen disease with invasive mucin‐secreting sweat gland differentiation: Report of a case and review of the literature

Squamoid eccrine ductal carcinoma of the scalp

Malignant Sweat Gland Tumors

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