Adenosquamous proliferation of the breast and low grade adenosquamous carcinoma: a common precursor of an uncommon cancer?

Wilsher, Mark James

doi:10.1097/pat.0000000000000115

Cited by 22 publications

(33 citation statements)

References 47 publications

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“…Although several case reports and relatively small cohorts have been reported over the years, LGASC remains poorly defined in terms of phenotype; in addition, its genetic profile is yet to be established . The immunohistochemical studies published to date have described LGASC as part of the triple‐negative breast cancer (TNBC) spectrum …”

Section: Introductionmentioning

confidence: 99%

“…6 Although several case reports and relatively small cohorts have been reported over the years, LGASC remains poorly defined in terms of phenotype; in addition, its genetic profile is yet to be established. 3,[6][7][8][9][10][11][12][13][14][15][16] The immunohistochemical studies published to date have described LGASC as part of the triple-negative breast cancer (TNBC) spectrum. 1,6,17,18 A genome-wide characterisation of copy number alterations has been performed on two cases, one of which showed a complex profile of copy number changes encompassing focal amplifications.…”

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confidence: 99%

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High rate of PIK3CA mutations but no TP53 mutations in low‐grade adenosquamous carcinoma of the breast

et al. 2018

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We reviewed the clinical and morphological features and detailed the immunohistochemical characteristics of a retrospective series of 13 LGASCs. Targeted sequencing of 50 genes was performed in 10 of 13 cases. Identified mutations were further assessed by Sanger sequencing in a validation series of 11 additional cases. All tumours showed a triple-negative immunophenotype, expressed 'basal' keratins, showed variable levels of epidermal growth factor receptor expression, and did not express androgen receptor. Sequencing analysis of the screening set of LGASCs revealed a high rate (seven of 10 cases) of PIK3CA mutations, whereas no TP53 mutations were found. All PIK3CA mutations were missense mutations located either in exon 20 (n = 6) or in exon 9 (n = 1). The global PIK3CA mutation rate, including the validation series, was 52% (11 of 21 cases). No disease recurrences were observed. [Correction added on 11 June 2018, after first online publication: The percentage of mutation rate was corrected to 52%] CONCLUSIONS: Our results indicate that LGASC of the breast is a low-grade triple-negative breast cancer that harbours a basal-like phenotype with no androgen receptor expression, and shows a high rate of PIK3CA mutations but no TP53 mutations.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

High rate of PIK3CA mutations but no TP53 mutations in low‐grade adenosquamous carcinoma of the breast

et al. 2018

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“…ST is regarded as a locally infiltrative, non‐ (or very rarely) metastasising tumour, currently thought to arise from breast ducts . Histologically, it closely resembles LGASC of the breast, which typically occurs in breast parenchyma and rarely occurs in the nipple, but has previously been reported in associated with NA It rarely metastasises, except when over 30 mm in size and after multiple recurrences . Both lesions characteristically may arise in association with benign breast lesions .…”

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confidence: 82%

Low‐grade adenosquamous carcinoma arising in association with a nipple adenoma

Wilsher¹,

Desai

Pinder

2020

Histopathology

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“…Low-grade adenosquamous carcinoma has been reported to arise in association with a number preexisting lesions, including papillomata, adenomyoepitheliomata, RS/complex sclerosing lesions, and fibroepithelial tumors. 64,[66][67][68][69] This association has led some authors to suggest that such lesions represent precursors to LGASC 62 ; however, further studies are necessary to support such a theory.…”

Section: Low-grade Adenosquamous Carcinomamentioning

confidence: 99%

“…58 Squamous metaplasia may also be seen in RSs, particularly in small glands in the nidus. [59][60][61][62] In core biopsy specimens, it may be difficult to appreciate the radial configuration of the lesion in the absence of the central nidus. Features that are helpful in suggesting RS include the centrifugal growth of the lesional glands as well as the presence of proliferative breast disease within and at the periphery of the lesion.…”

Section: Radial Scarmentioning

confidence: 99%

Small Glandular Proliferations of the Breast With Absent or Attenuated Myoepithelial Reactivity by Immunohistochemistry: A Review Focusing on the Differential Diagnosis and Interpretative Pitfalls

Ginter

Shin²,

D’Alfonso³

2016

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Small glandular proliferations of the breast encompass a variety of benign, atypical, and malignant lesions that show some overlapping morphologic features. Myoepithelial stains are frequently used in the workup of these lesions in order to rule out or establish a diagnosis of invasive carcinoma. Some benign lesions show absent or diminished myoepithelial staining, and may represent an interpretative pitfall, particularly in small core biopsy samples. Objective.—To review small glandular proliferations of the breast that show absent or diminished staining with myoepithelial immunohistochemical markers. Data Sources.—The study comprised a review of published literature and clinical case material. Conclusions.—The interpretation of myoepithelial stains in small glandular proliferations of the breast can, on some occasions, represent a challenge in diagnosing these lesions. Recognition of the key histopathologic features and immunohistochemical staining patterns of the entities in the differential diagnosis is crucial in their workup.

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Adenosquamous proliferation of the breast and low grade adenosquamous carcinoma: a common precursor of an uncommon cancer?

Cited by 22 publications

References 47 publications

High rate of PIK3CA mutations but no TP53 mutations in low‐grade adenosquamous carcinoma of the breast

High rate of PIK3CA mutations but no TP53 mutations in low‐grade adenosquamous carcinoma of the breast

Low‐grade adenosquamous carcinoma arising in association with a nipple adenoma

Small Glandular Proliferations of the Breast With Absent or Attenuated Myoepithelial Reactivity by Immunohistochemistry: A Review Focusing on the Differential Diagnosis and Interpretative Pitfalls

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