2004
DOI: 10.1016/j.bbrc.2004.05.097
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Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis

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Cited by 38 publications
(36 citation statements)
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“…The dominant-negative Cx43 characterized in this study should avoid most of these issues. Unlike previous reports that suggested that introduction of wild type or mutant connexins (including Cx43del 130-136 ) might affect cell proliferation or induce cell death [13,14,32], we found no evidence that expression of either Cx43del [130][131][132][133][134][135][136] or Cx43 altered the growth or viability of our HeLa cell cultures. Additional experiments will be required to reconcile these results, but it is possible that all cell types are not similarly affected by these connexins.…”
Section: Discussioncontrasting
confidence: 99%
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“…The dominant-negative Cx43 characterized in this study should avoid most of these issues. Unlike previous reports that suggested that introduction of wild type or mutant connexins (including Cx43del 130-136 ) might affect cell proliferation or induce cell death [13,14,32], we found no evidence that expression of either Cx43del [130][131][132][133][134][135][136] or Cx43 altered the growth or viability of our HeLa cell cultures. Additional experiments will be required to reconcile these results, but it is possible that all cell types are not similarly affected by these connexins.…”
Section: Discussioncontrasting
confidence: 99%
“…The production of recombinant adenoviruses containing rat Cx43, mouse Cx40, and human Cx37 has recently been described [13]. A DNA fragment containing rat Cx43 with a deletion of amino acids 130-136 (Cx43del [130][131][132][133][134][135][136] ) and an epitope tag from the influenza hemagglutinin (HA) attached to its carboxyl terminus was obtained by the polymerase chain reaction.…”
Section: Connexin Adenovirusesmentioning
confidence: 99%
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“…Several studies have shown that changes in GJIC can influence cell survival or apoptosis. [28][29][30] In rat ventricular myocytes, reduced Cx43 expression resulted in increased apoptosis. 31 Similar effects were found in mammary epithelial cells with lower connexin 26 expression.…”
Section: Introductionmentioning
confidence: 99%
“…For instance, when HSVtk-transduced endothelial cells and non-HSVtk-transduced tumor cells were co-cultured, treatment with GCV resulted in the BE-dependent death of both endothelial and tumor cells in vitro and in vivo (Trepel et al 2009). Targeting human umbilical vein endothelial cells (HUVECs) with a Cx37-encoding adenovirus induced their death by apoptosis (Seul et al 2004). …”
Section: Targeting Tumor Cells Through Gjic With Their Cellular Envirmentioning
confidence: 99%