Adenoviral gene transfer of basic fibroblast growth factor promotes angiogenesis in rat brain

Yukawa, Hiroyuki; Takahashi, Jun; Si, Miyatake; Saiki, Masaaki; Matsuoka, Norihiro; Akimoto, Masayuki; Yanamoto, Hiroji; Nagata, Izumi; Kikuchi, Hiroe; Hashimoto, Nobuo

doi:10.1038/sj.gt.3301182

Cited by 31 publications

(28 citation statements)

References 51 publications

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“…As expected, the microbubble-enhanced ultrasound method resulted in marked enhancement of the transfection efficiency as compared to naked plasmid DNA alone. In contrast to previous data using vectors such as adenovirus 22 or HVJ-envelope vector, 23 gene expression was limited to the insonated sites with intracisternal injection. Using the microbubble-enhanced ultrasound method, the transfected cells were mainly meningeal cells, but not neurons or glia.…”

Section: Discussioncontrasting

confidence: 73%

Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound

et al. 2004

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Section: Discussioncontrasting

confidence: 73%

Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound

et al. 2004

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“…This approach alleviates problems associated with existing methods for inhibiting apoptosis, including limited delivery into the cell, repeated or chronic injection/infusion protocols, and lack of specificity to apoptotic pathways. Over the past two years, several studies reported the use of replication-deficient viral-mediated gene transfer to successfully overexpress a number of proteins in the CNS (Choi-Lundberg et al, 1997;Bemelmans et al, 1999;Franklin et al, 1999;Kitagawa et al, 1999;Bohn et al, 2000;Eberhardt et al, 2000;Fathallah-Shaykh et al, 2000;Huber et al, 2000;Kordower et al, 2000;Watabe et al, 2000;Yagi et al, 2000;Yukawa et al, 2000;Boer et al, 2001;Watabe et al, 2001). Recombinant adenovirus gene transfer has also been used to express functional proteins in the spinal cord (Smith et al, 1996;Smith et al, 1997;Romero and Smith, 1998;Smith and Romero, 1999;Romero et al, 2000).…”

Section: Therapeutic Interventions: Delivery Of Anti-apoptotic Genes mentioning

confidence: 99%

Apoptotic Cell Death Following Traumatic Injury to the Central Nervous System

Springer¹

2002

BMB Reports

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Apoptotic cell death is a fundamental and highly regulated biological process in which a cell is instructed to actively participate in its own demise. This process of cellular suicide is activated by developmental and environmental cues and normally plays an essential role in eliminating superfluous, damaged, and senescent cells of many tissue types. In recent years, a number of experimental studies have provided evidence of widespread neuronal and glial apoptosis following injury to the central nervous system (CNS). These studies indicate that injury-induced apoptosis can be detected from hours to days following injury and may contribute to neurological dysfunction. Given these findings, understanding the biochemical signaling events controlling apoptosis is a first step towards developing therapeutic agents that target this cell death process. This review will focus on molecular cell death pathways that are responsible for generating the apoptotic phenotype. It will also summarize what is currently known about the apoptotic signals that are activated in the injured CNS, and what potential strategies might be pursued to reduce this cell death process as a means to promote functional recovery.

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“…Glioblastoma is among the most highly vascularized of all tumors and increased expression of bFGF correlates with progression of a wide variety of solid tumors (46). Adenoviral gene transfer of bFGF was found to promote angiogenesis in rat brains (47). However, a clear correlation between increased bFGF expression and glioma progression has not been demonstrated in glioma suggesting that bFGF is not the principle mediator of angiogenesis (48).…”

Section: Promoters Of Angiogenesismentioning

confidence: 99%