Adenoviral Infection in Suckling Arabian Foals

Five of six immunodeficient Arabian foals that died of adenoviral infection were found to be infected with an intestinal coccidian of the genus Cryptosporidium. Various developmental stages of the organism were found in the microvillous border of the intestinal mucosa. The foals had diarrhea but it was not possible to separate the effects of the cryptosporidial infection from those of the concomitant adenoviral enteritis.

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“…All foals also had typical lesions of adenovirus infection [5] and hypoplasia of all lymphoid organs as has been described [ 61.…”

Section: Resultsmentioning

confidence: 63%

Cryptosporidiosis in Immunodeficient Arabian Foals

1978

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“…The first equine SCID cases were reported in 5 to 8-monthsold 29 Arabian foals, had limited resistance to infections (10). Later, similar immunodeficiency syndromes were also described by several researchers in Arabian horses from different geographic regions (6,9,23). Studies indicated that the immunodeficiency observed in these foals was caused by lymphopenia, hypogammaglobulinaemia, the failure of germinal centers to form in lymphoid organs (7,10,12,13,25).…”

Section: Introductionmentioning

confidence: 82%

“…Most of the affected foals with severe immunodeficiency generally die before they reached to their six months of ages. Thus, SCID is one of the most frequent causes of Arabian foal deaths, which are unresponsive to the antimicrobial treatment (1,4,8,9,19). It also means that, even though all-infectious etiologies lying under the clinical course are treated, SCID maintains tremendous immunodeficiency in those foals.…”

Section: Introductionmentioning

confidence: 99%

Investigation of severe combined immunodeficiency (SCID) disease of Arabian horses raised at the state stud farms in Turkey

KUL¹,

Bengi;²,

ERTUĞRUL³

et al. 2014

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:Severe Combined Immunodeficiency (SCID) is a lethal and autosomal recessive hereditary disorder, which has frequently been reported in Arabian horses, dogs, mice and humans. The genetic basis of equine SCID is 5-base pairs deletion in the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) gene. Up to date, there is no information on the presence of SCID in Arabian horses reared in Turkey either by clinical observation or molecular diagnosis. The main aims of this study were to investigate the presence of SCID mutant allele carrier and to determine SCID incidence in Turkey using molecular techniques. In the study, DNA samples were obtained from 239 Arabian horses raised in state stud farms of Turkey (Karacabey, n=70; Anadolu, n=70 and Sultansuyu, n=99) and they were analyzed using DNA-PKcs gene specific polymerase chain reaction and fragment analysis by capillary electrophoresis. The result of the study showed that, none of the examined Arabian horses has SCID mutation on their responsible gene region. In conclusion, no SCID carrier was identified among examined stud Arabian horses that were representing the 65.5% (239 out of 365) of all officially registered stud animals in Turkey. It is believed that, this first genetic screening study focused on the SCID determination at national level and the evidence of the disease absence have the potential to increase breeding value of Arabian horses originated from Turkey.

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“…Affected foals usually develop bronchopneumonia and occasionally conjunctival infection and panuveitis, although the latter is seldom clinically evident (McChesney et al 1973). Affected foals usually develop bronchopneumonia and occasionally conjunctival infection and panuveitis, although the latter is seldom clinically evident (McChesney et al 1973).…”

Section: Local/metastatic Spread Of Diseasementioning

confidence: 99%

Ocular manifestations of systemic disease in horses

Hughes

2010

Equine Veterinary Journal

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Summary Ocular manifestations may develop in many systemic diseases of horses; however, signs may not be observed unless ophthalmological examination is specifically undertaken. Recognition and assessment of ocular lesions in horses with systemic disease is desirable to facilitate diagnosis and determination of treatment options and diagnosis for both the underlying systemic disease and ocular manifestations. The purpose of this article is to review systemic diseases of horses that may have ocular signs as part of the disease process. Systemic diseases are discussed in categories of pathways for development of ocular signs, namely immunological disease, neurological disease or local/systemic spread of disease.

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Adenoviral Infection in Suckling Arabian Foals

Cited by 48 publications

References 12 publications

Cryptosporidiosis in Immunodeficient Arabian Foals

Cryptosporidiosis in Immunodeficient Arabian Foals

Investigation of severe combined immunodeficiency (SCID) disease of Arabian horses raised at the state stud farms in Turkey

Ocular manifestations of systemic disease in horses

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