2002
DOI: 10.1016/s0002-9440(10)61120-0
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Adenoviral Transfer of Murine Oncostatin M Elicits Periosteal Bone Apposition in Knee Joints of Mice, Despite Synovial Inflammation and Up-Regulated Expression of Interleukin-6 and Receptor Activator of Nuclear Factor-κB Ligand

Abstract: Oncostatin M (OSM) has been described as a bone-remodeling factor either stimulating osteoblast activity or osteoclast formation in vitro. To elucidate the in vivo effect of OSM on bone remodeling, we injected an adenoviral vector encoding murine OSM in knee joints of mice. OSM strongly induced interleukin (IL)-6 gene expression, a known mediator of osteoclast development. We investigated the OSM effect in wild-type and IL-6-deficient mice and found a similar degree of OSM-induced joint inflammation. Within th… Show more

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Cited by 55 publications
(66 citation statements)
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“…For example, local over-expression of OSM in the mouse knee joint induces changes to the joint that resemble OA, including cartilage destruction and periosteal bone formation similar to osteophytes (98,99). OSM also induces proteoglycan loss and cartilage damage ex-vivo (97,100).…”
Section: Osteoarthritismentioning
confidence: 99%
“…For example, local over-expression of OSM in the mouse knee joint induces changes to the joint that resemble OA, including cartilage destruction and periosteal bone formation similar to osteophytes (98,99). OSM also induces proteoglycan loss and cartilage damage ex-vivo (97,100).…”
Section: Osteoarthritismentioning
confidence: 99%
“…While it has been reported previously that gp130 family members, particularly IL-6 and OsM, regulate articular cartilage breakdown and may play a role in the pathogenesis of various aspects of arthritis (41,42), gp130 family members have not been studied in growth plate chondrocytes or in longitudinal bone growth. The LIF-Rβ knockout mouse exhibits reduced postnatal skeletal growth (15), but changes in the growth plates of these mice have not been reported.…”
Section: Figurementioning
confidence: 99%
“…hOSM has been reported either to inhibit or stimulate a bone formation-associated enzyme, alkaline phosphatase (ALP), in mouse primary osteoblasts (22) and murine stromal cells (23), respectively. Adenoviral transfer of mOSM to a mouse arthritis model stimulated bone formation (24), and administration of hOSM to human adipose-derived mesenchymal stem cells promoted ALP activity and inhibited adipocyte differentiation (25), indicating that, within species, hOSM and mOSM consistently increase osteoblast differentiation.…”
Section: Introductionmentioning
confidence: 98%