Adenoviridae: Second Report

Wigand, R.; Bartha, A; Dreizin, R. S.; Esche, Helmut; Ginsberg, H.S.; Green, M.; Hierholzer, John C.; Kalter, S. S.; McFerran, J.B.; Pettersson, Ulf; Russell, W. C.; Wadell, Göran

doi:10.1159/000149322

Cited by 120 publications

(68 citation statements)

References 7 publications

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“…The low NT titer was found in the reaction only with HAdV-8 antiserum (Table 3). Consequently, the new serotype has been defined on the basis of its immunological distinctiveness, namely, a homologous neutralization titer/heterologous neutralization titer ratio of Ͼ16 in either direction (29). Therefore, these results suggest that the hexon L-1 and L-2 regions, which contain the main NT ε determinant of C075/Matsuyama/2003, are from HAdV-22.…”

Section: Resultsmentioning

confidence: 94%

“…Among these, HAdV-8, -19, and -37 cause more-severe epidemic keratoconjunctivitis (EKC) than the others (2)(3)(4). Serotyping of HAdVs is generally performed by virus isolation followed by a neutralization test (NT) and hemagglutination inhibition test (HI) using type-specific antiserum (29). To date, amplification of the genome by PCR and determination of the nucleotide sequences followed by phylogenetic analysis have become the general procedure for both the classification and identification of HAdVs (21,22,28).…”

Section: We Propose That This Virus Is a New Hexon-chimeric Intermedimentioning

confidence: 99%

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Epidemic Keratoconjunctivitis Due to the Novel Hexon-Chimeric-Intermediate 22,37/H8 Human Adenovirus

et al. 2008

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In a 2-month period in 2003, we encountered an outbreak of epidemic keratoconjunctivitis (EKC) in Japan. We detected 67 human adenoviruses (HAdVs) by PCR from eye swabs of patients with EKC at five eye clinics in different parts of Japan. Forty-one of the 67 HAdV DNAs from the swabs were identified as HAdV-37 by phylogenetic analysis using a partial hexon gene sequence. When the restriction patterns of these viral genomes were compared with that of the HAdV-37 prototype strain, one isolate showed a never-before-seen restriction pattern. Within 1 year, we encountered three more EKC cases caused by a genetically identical virus: two nosocomial infections at two different university hospitals and a sporadic infection at an eye clinic. We determined the nucleotide sequences of the full-length hexon and fiber genes of these isolates and compared them to those of the 51 prototype strains. Surprisingly, the sequence of the hexon ( determinant) loop-1 and -2 regions showed the highest nucleotide identity with HAdV-22, a rare EKC isolate. However, the nucleotide sequence of the fiber gene was identical to that of the HAdV-8 prototype strain. 22 We propose that this virus is a new hexon-chimeric intermediate HAdV-22,37/H8, and may be an etiological agent of EKC.

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Section: Resultsmentioning

confidence: 94%

Section: We Propose That This Virus Is a New Hexon-chimeric Intermedimentioning

confidence: 99%

Epidemic Keratoconjunctivitis Due to the Novel Hexon-Chimeric-Intermediate 22,37/H8 Human Adenovirus

et al. 2008

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“…These are egg-drop syndrome 76 in hens (group III), haemorrhagic enteritis of turkeys and marble spleen disease of pheasants (group II). The conventional adenoviruses (group I) are isolated from chickens (FAVI-12), geese (GAV1-3), ducks (DAV2) and turkeys (TAV1, 2; Wigand et al, 1982). The fowl adenoviruses (FAV1-12) are widely distributed in poultry flocks (Monreal, 1984).…”

Section: Introductionmentioning

confidence: 99%

Some strains of serotype 4 fowl adenoviruses cause inclusion body hepatitis and hydropericardium syndrome in chickens

et al. 1998

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Fowl adenoviruses were isolated and characterized from severe cases of hydropericardium syndrome in Ecuador and Pakistan. All were neutralized by antibodies against serotypes 4 and 11. Cross-neutralization tests and restriction enzyme analysis strengthen the classification as serotype 4 strains. The restriction endonucleases used allowed the differentiation among field isolates and reference strains. All field isolates tested induced high embryo mortality. One-day-old specific pathogen free (SPF) chicks were infected with 10 5 plaque-forming units by natural routes to reproduce the disease with plaque purified virus. Whereas no mortality was seen with the reference strain, the mortality with the field isolates was 100%. A reduced mortality occurred with a lower infectious dose. Field isolate K1013 from Ecuador was also highly pathogenic for 1-to 3-week-old SPF chicks after intramuscular inoculation. The main pathological signs were swollen livers, severe hydropericardium and nephritis, reflecting the field situation and underlining the role of FAV4 strains in the aetiology of infectious hydropericardium.

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“…The complete sequence analysis of both the CAV-1 and CAV-2 genome has revealed about 75% nucleotide identity [49,114]. Although CAV-1 and CAV-2 are related genetically and antigenically [109,168], they have different tissue tropism. Vascular endothelial cells and hepatic and renal parenchymal cells are the main targets of CAV-1, while the respiratory tract epithelium and, to a limited degree, the intestinal epithelium, are the targets of CAV-2 [3,140,153].…”

Section: Canine Adenovirus Typementioning

confidence: 99%

Canine respiratory viruses

2007

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-Acute contagious respiratory disease (kennel cough) is commonly described in dogs worldwide. The disease appears to be multifactorial and a number of viral and bacterial pathogens have been reported as potential aetiological agents, including canine parainfluenza virus, canine adenovirus and Bordetella bronchiseptica, as well as mycoplasmas, Streptococcus equi subsp. zooepidemicus, canine herpesvirus and reovirus-1,-2 and -3. Enhancement of pathogenicity by multiple infections can result in more severe clinical forms. In addition, acute respiratory diseases associated with infection by influenza A virus, and group I and II coronaviruses, have been described recently in dogs. Host species shifts and tropism changes are likely responsible for the onset of these new pathogens. The importance of the viral agents in the kennel cough complex is discussed.

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Adenoviridae: Second Report

Cited by 120 publications

References 7 publications

Epidemic Keratoconjunctivitis Due to the Novel Hexon-Chimeric-Intermediate 22,37/H8 Human Adenovirus

Epidemic Keratoconjunctivitis Due to the Novel Hexon-Chimeric-Intermediate 22,37/H8 Human Adenovirus

Some strains of serotype 4 fowl adenoviruses cause inclusion body hepatitis and hydropericardium syndrome in chickens

Canine respiratory viruses

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