Adenovirus and RSV infections during pregnancy and their relationship to orofacial clefts

Molnárová, Agáta; Palenčár, Drahomír; Fekiačová, Dagmar; Bieliková, Eva; Tichá, Elena; Mach, Mojmı́r

doi:10.2478/s11756-019-00404-x

Cited by 2 publications

(1 citation statement)

References 55 publications

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“…In both upper and lower respiratory tract infections (LRTIs), RSV has been implicated as the second most prevalent cause of death, largely affecting children living in low‐and‐middle‐income countries 2,3 . Acute lower respiratory infection (ALRI) is a leading cause of morbidity in children younger than 5 years, on a global scale 4 . During the first 6 months of life, children are most at risk of contracting RSV, as they are mainly protected by transferred maternal immunity.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and molecular characterization of human respiratory syncytial virus and human adenovirus among children in Ado‐Ekiti, Nigeria

Idris

Kolawole

2021

Journal of Medical Virology

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In children, the respiratory syncytial virus and adenovirus majorly cause acute respiratory infections. The study evaluated the seroprevalence and conducted the molecular characterization of human respiratory syncytial virus (HRSV) and human adenovirus (HAdV) among children. Venous blood, nasopharyngeal, and oropharyngeal swabs were collected from children presenting with acute respiratory infections in a tertiary health facility in Ado-Ekiti, Nigeria. A serological investigation was carried out on the sera samples for the detection of anti-HRSV immunoglobulin M (IgM), anti-HRSV IgG, anti-HAdV IgM, and anti-HAdV IgG using ELISA (enzyme-linked immunosorbent assay) kits. The amplification and sequencing of HRSV and HAdV were carried out using specific primer pairs that targeted the glycoprotein (G) gene of HRSV and the hexon gene of HAdV, respectively.The seroprevalence of HRSV IgG and IgM was 73% and 7.5%, respectively, while the seroprevalence of HAdV IgG and IgM was 98.5% and 8.5%, respectively. The age of enrolled children, presence of fever, and cough were associated (p < 0.05) with the infection. HRSV subtype B (HRSV-B) (13.3%), and species of HAdV (Mastadenovirus B and C) (11.7%) were detected among the studied population. There was no viral coinfection with both HRSV and HAdV. In infancy and early childhood, HRSV-B, HAdV species B and C are common etiologic agents of respiratory infections as reported in this study. Further studies on molecular characterization of respiratory tract viruses including circulating respiratory syncytial virus and adenovirus are hereby advocated.

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Section: Introductionmentioning

confidence: 99%

Seroprevalence and molecular characterization of human respiratory syncytial virus and human adenovirus among children in Ado‐Ekiti, Nigeria

Idris

Kolawole

2021

Journal of Medical Virology

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A recombinant virus-like particle vaccine against adenovirus-7 induces a potent humoral response

Mazboudi,

Mulhall Maasz,

Resch

et al. 2023

npj Vaccines

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Adenoviruses (AdVs) cause infections in humans that range from mild to severe, and can cause outbreaks particularly in close contact settings. Several human AdV types have been identified, which can cause a wide array of clinical manifestations. AdV types 4 and 7 (AdV-4 and AdV-7), which are among the most commonly circulating types in the United States, are known to cause acute respiratory disease that can result in hospitalization and rarely, death. Currently, the only vaccines approved for use in humans are live virus vaccines against AdV-4 and AdV-7, though these vaccines are only authorized for use in U.S. military personnel. While they are efficacious, use of these live virus vaccines carries considerable risks of vaccine-associated viral shedding and recombination. Here, we present an alternative vaccination strategy against AdV-7 using the virus-like particle platform (AdVLP-7). We describe the production of stable recombinant AdVLP-7, and demonstrate that AdVLP-7 is structurally analogous to wild-type AdV-7 virions (WT AdV-7). Preclinical immunogenicity studies in mice show that AdVLP-7 elicits a potent humoral immune response, comparable to that observed in mice immunized with WT AdV-7. Specifically, AdVLP-7 induces high titers of antibodies against AdV-7-specific antigens that can effectively neutralize AdV-7.

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Adenovirus and RSV infections during pregnancy and their relationship to orofacial clefts

Cited by 2 publications

References 55 publications

Seroprevalence and molecular characterization of human respiratory syncytial virus and human adenovirus among children in Ado‐Ekiti, Nigeria

Seroprevalence and molecular characterization of human respiratory syncytial virus and human adenovirus among children in Ado‐Ekiti, Nigeria

A recombinant virus-like particle vaccine against adenovirus-7 induces a potent humoral response

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