Adenovirus as Tools in Animal Health

Rojas, José M.; Sevilla, Noemı́; Martı́n, Verónica

doi:10.5772/intechopen.79132

Cited by 8 publications

(13 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Human adenovirus 5 has been extensively used in vivo as a sustained gene delivery method in vivo [ 27 , 30 , 47 ]. While its major drawback for clinical use in humans is the widespread pre-existing immunity in the population [ 48 , 49 , 50 ], this is not the case for sheep, as this host is unlikely to have been exposed to the recombinant vector [ 30 , 51 , 52 ]. For example, inoculation of adenoviral vectors expressing bovine IFN type III has been shown to protect cattle from a subsequent FMDV challenge [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

“…Non-replicative human adenoviral vectors have been successfully used as efficient in vivo protein delivery systems [27][28][29] and their use is particularly suited for veterinary medicine, as the host lacks pre-existing immunity to this human vector. Additionally, these vectors are safe, present low toxicity, transduce a broad spectrum of host species, and are relatively easy to manipulate and distribute [30]. This work identifies the capacity of soluble ovine OX40L and CD70 forms to activate cells expressing their cognate receptor and stimulate ovine T cell responses, which points to their potential use as adjuvant for vaccination strategies in ruminants…”

Section: Introductionmentioning

confidence: 91%

See 1 more Smart Citation

Activation of OX40 and CD27 Costimulatory Signalling in Sheep through Recombinant Ovine Ligands

et al. 2020

Self Cite

View full text Add to dashboard Cite

Members of the tumour necrosis factor (TNF) superfamily OX40L and CD70 and their receptors are costimulating signalling axes critical for adequate T cell activation in humans and mice but characterisation of these molecules in other species including ruminants is lacking. Here we cloned and expressed the predicted ovine orthologues of the receptors OX40 and CD27, as well as soluble recombinant forms of their potential ovine ligands, OaOX40L and OaCD70. Using biochemical and immunofluorescence analyses, we show that both signalling axes are functional in sheep. We show that oligomeric recombinant ligand constructs are able to induce signalling through their receptors on transfected cells. Recombinant defective human adenoviruses were constructed to express the soluble forms of OaOX40L and OaCD70. Both proteins were detected in the supernatant of adenovirus-infected cells and shown to activate NF-κB signalling pathway through their cognate receptor. These adenovirus-secreted OaOX40L and OaCD70 forms could also activate ovine T cell proliferation and enhance IFN-γ production in CD4+ and CD8+ T cells. Altogether, this study provides the first characterisation of the ovine costimulatory OX40L-OX40 and CD70-CD27 signalling axes, and indicates that their activation in vivo may be useful to enhance vaccination-induced immune responses in sheep and other ruminants.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Activation of OX40 and CD27 Costimulatory Signalling in Sheep through Recombinant Ovine Ligands

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, several studies have been achieved concerning the thermal entanglement in spin diamond chains [16][17][18][19][20]. The quantum teleportation through a couple of Ising-XXZ diamond chain has also been examined in detail in reference [21]. Furthermore, the quantum correlation has been quantified by the trace distance discord to describe the quantum critical behaviors in the Ising-XXZ diamond structure at finite temperature [22].…”

Section: Introductionmentioning

confidence: 99%

Quantum entanglement in the neighborhood of pseudo-transition for a spin-1/2 Ising-XYZ diamond chain

Carvalho

Torrico

Souza

et al. 2018

Journal of Magnetism and Magnetic Materials

View full text Add to dashboard Cite

Recently has been observed for some one-dimensional models that exhibit unexpected pseudotransitions and quasi-phases. This pseudo-transition resembles a first-and second-order phase transition simultaneously. One of those models is the spin-1/2 Ising-XYZ diamond chain, composed of Ising spin particles at the nodal sites and the Heisenberg spin particles at the interstitial sites. Where we assume Ising-type interaction between the nodal and interstitial sites, the Heisenberg-type interaction between interstitial sites, and with an external magnetic field applied along the z-axis. This model presents an exact analytical solution applying the transfer matrix technique, which shows 3 phases at zero temperature in the vicinity of pseudo-transition. The pseudo-transition separates quasi-phases, these quasi-phases still hold at a finite temperature most of the pattern configurations of a true phase at zero temperature. Here we study the quantum entanglement of pair spin particles in the quasi-phase regions, which can be measured through the concurrence. Then we observe an unexpected behavior in the concurrence, that is below pseudocritical temperature the concurrence remains almost constant up to pseudo-critical temperature, but above the pseudo-critical temperature, the concurrence behaves as for the standard one-dimensional spin models.Further, we consider the entropy behavior of the system, below pseudo-critical temperature the entropy becomes almost null, while above pseudo-critical temperature the system exhibits standard behavior as for ordinary one-dimensional spin models.

show abstract

“…The thermal entanglement properties of several kinds of Ising-Heisenberg diamond chain models have been studied in Ising-XXZ model on diamond chain [9], Ising-XY Z model on diamond chain [10] and the mixed spin-1/2 and spin-1 Ising-Heisenberg model on diamond chain [11]. The quantum teleportation via a couple of quantum channels composed of XXZ dimers in an Ising-XXZ diamond chain has been reported [12]. Furthermore, the quantum correlation has been quantified by the trace distance discord to describe the quantum critical behaviors in the Ising-XXZ diamond structure at finite temperature [13].…”

Section: Introductionmentioning

confidence: 99%

Tuning the thermal entanglement in a Ising-XXZ diamond chain with two impurities

Carvalho

Rojas

Souza

et al. 2019

Quantum Inf Process

View full text Add to dashboard Cite

We study the local thermal entanglement in a spin-1/2 Ising-XXZ diamond structure with two impurities. In this spin chain, we have the two impurities with an isolated XXZ dimer between them. We focus on the study of the thermal entanglement in this dimer. The main goal of this paper is to provide a good understanding of the effect of impurities in the entanglement of the model. This model is exactly solved by a rigorous treatment based on the transfer-matrix method. Our results show that the entanglement can be tuned by varying the impurities parameters in this system. In addition, it is shown that the thermal entanglement for such a model exhibits a clear performance improvement when we control and manipulate the impurities compared to the original model without impurities. Finally, the impurities can be manipulated to locally control the thermal entanglement, unlike the original model where it is done globally. arXiv:1901.07690v1 [quant-ph] 23 Jan 2019

show abstract

Adenovirus as Tools in Animal Health

Cited by 8 publications

References 93 publications

Activation of OX40 and CD27 Costimulatory Signalling in Sheep through Recombinant Ovine Ligands

Activation of OX40 and CD27 Costimulatory Signalling in Sheep through Recombinant Ovine Ligands

Quantum entanglement in the neighborhood of pseudo-transition for a spin-1/2 Ising-XYZ diamond chain

Tuning the thermal entanglement in a Ising-XXZ diamond chain with two impurities

Contact Info

Product

Resources

About