Adenovirus-associated Deaths in US Military during Postvaccination Period, 1999–2010

Potter, Robert N.; Cantrell, Joyce A.; Mallak, Craig T.; Gaydos, Joel C.

doi:10.3201/eid1803.111238

Cited by 65 publications

(52 citation statements)

References 12 publications

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“…During the 1999–2010 lapse in adenovirus vaccine coverage, 8 adenovirus-infected service members died ( 13 ). Estimates showed each infection costs ≈$3,838, and each year the vaccine prevents 1 death, 1,100–2,700 hospitalizations, and 13,000 febrile infections among military recruits.…”

Section: Discussionmentioning

confidence: 99%

Acute Respiratory Disease in US Army Trainees 3 Years after Reintroduction of Adenovirus Vaccine1

Clemmons¹,

McCormic²,

Gaydos³

et al. 2017

Emerg. Infect. Dis.

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Section: Discussionmentioning

confidence: 99%

Acute Respiratory Disease in US Army Trainees 3 Years after Reintroduction of Adenovirus Vaccine1

Clemmons¹,

McCormic²,

Gaydos³

et al. 2017

Emerg. Infect. Dis.

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“…All patients were young, previously healthy soldiers. Although several studies have described the clinical features of adenovirus infection among military personnel (7)(8)(9)(10)(11)(12)(13), few studies have compared the clinical characteristics of pneumonic and non-pneumonic adenovirus cases or evaluated the risk factors associated with military training courses. Furthermore, few reports have provided detailed descriptions of the radiological features of adenovirus infections by means such as thinsection computed tomography (CT) (7,9).…”

Section: Introductionmentioning

confidence: 99%

Outbreak of Febrile Respiratory Illness Caused by Adenovirus at a South Korean Military Training Facility: Clinical and Radiological Characteristics of Adenovirus Pneumonia

Hwang

Park²,

Yong³

et al. 2013

Jpn J Infect Dis

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SUMMARY: Adenovirus often causes respiratory disease outbreaks in military training soldiers. Compared with adenovirus pneumonia in young military adults, symptoms arising from febrile respiratory illness (FRI) caused by adenovirus have not been previously evaluated in Korean soldiers. We conducted an event-based outbreak investigation involving 712 male soldiers aged 19 to 21 years from March 14 to 30, 2012 to evaluate the epidemiological and clinical characteristics of patients with pneumonia and FRI caused by adenovirus. We described the laboratory and radiological characteristics of patients with adenovirus pneumonia. Among these, 407 cases of FRI and 15 cases of pneumonia were identified through active surveillance (attack rate of FRI, 57.16z; attack rate of pneumonia, 2.11z). Fire training and march training may present environmental risk factors for adenovirus-associated outbreaks. Most symptoms were mild. The most frequent symptom in patients with pneumonia and FRI was cough. Patients with pneumonia were associated with an increased incidence of dizziness (crude odds ratio [cOR], 9.65; 95z confidence interval [CI], 2.38-37.15) and a decreased incidence of rhinorrhea (cOR, 0.15; 95z CI, 0.04-0.53) during adenovirus-associated outbreaks. Differential leukocyte count revealed high monocytes, low lymphocytes, and low eosinophils, and chest computed tomography revealed a consolidation pattern and right lobar pneumonia. These findings warrant a high level of suspicion for adenovirus pneumonia.

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“…6H and I) and can cause increased lung pathology (Fig. 6) and more severe clinical illness (1,4,6,(29)(30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

Low-Level Expression of the E1B 20-Kilodalton Protein by Adenovirus 14p1 Enhances Viral Immunopathogenesis

Radke

Yong

Cook

2016

J Virol

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Adenovirus 14p1 (Ad14p1) is an emergent variant of Ad serotype 14 (Ad14) that has caused increased severity of respiratory illnesses during globally distributed outbreaks, including cases of acute respiratory distress syndrome and death. We found that human cell infection with Ad14p1 results in markedly decreased expression of the E1B 20-kilodalton (20K) protein compared to that with infection with wild-type (wt) Ad14. This reduced Ad14p1 E1B 20K expression caused a loss-of-function phenotype of Ad-infected cell corpses that, in contrast to cells infected with wt Ad14, either failed to repress or increased NF-B-dependent, proinflammatory cytokine responses of responder human alveolar macrophages. A small-animal model of Ad14-induced lung infection was used to test the translational relevance of these in vitro observations. Intratracheal infection of Syrian hamsters with Ad14p1 caused a marked, patchy bronchopneumonia, whereas hamster infection with wt Ad14 caused minimal peribronchial inflammation. These results suggest that this difference in E1B 20K gene expression during Ad14p1 infection and its modulating effect on the interactions between Ad14-infected cells and the host innate immune response could explain the increased immunopathogenic potential and associated increase in clinical illness in some people infected with the Ad14p1 outbreak strain. IMPORTANCE We previously reported that Ad-infected human cells exhibit E1B 19K-dependent repression of virally induced, NF-B-depen-

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Adenovirus-associated Deaths in US Military during Postvaccination Period, 1999–2010

Cited by 65 publications

References 12 publications

Acute Respiratory Disease in US Army Trainees 3 Years after Reintroduction of Adenovirus Vaccine1

Acute Respiratory Disease in US Army Trainees 3 Years after Reintroduction of Adenovirus Vaccine1

Outbreak of Febrile Respiratory Illness Caused by Adenovirus at a South Korean Military Training Facility: Clinical and Radiological Characteristics of Adenovirus Pneumonia

Low-Level Expression of the E1B 20-Kilodalton Protein by Adenovirus 14p1 Enhances Viral Immunopathogenesis

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