Adenovirus en Niños Menores de Cinco Años. Patrones de Circulación, Características Clínicas y Epidemiológicas en Colombia, 1997-2003

Herrera-Rodríguez, Diana H.; Hoz, Fernando de la; Mariño, Cristina; Ramirez, E.R.; López, Juan Diego; Vélez, Consuelo

doi:10.1590/s0124-00642007000300010

Cited by 16 publications

(14 citation statements)

References 13 publications

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“…This lack of seasonality of HAdv infection has been described in other South American countries such as Colombia [38], Chile [44], and Brazil [54]. Nevertheless, we noted certain periods, such as the latter half of 2008, when either the absolute number or the proportion of HAdv identified (per total number of ILI cases) were elevated.…”

Section: Discussionsupporting

confidence: 73%

“…We also found that 5.3% of children younger than 5 years with ILI or SARI were infected with HAdv, a finding similar to many other South American HAdv studies. In Colombia, 2.6% (47/1743) of respiratory samples from children under 5 with ILI or SARI contained HAdv [38]. In Brazil, samples collected from pediatric patients with ILI or SARI (<5 years old) demonstrated a broad range of proportions containing HAdv: 6.8% (23/336) in São Paulo [39], 6.0% (52/862) in Rio Grande do Sul [40], and 2.3% (11/482) in Salvador, Bahia [41].…”

Section: Discussionmentioning

confidence: 99%

“…Studies from Colombia, Chile, Argentina, Brazil, and Cuba found a significantly higher M/F ratio, 2.3 [38], 1.5 [44] and 2.2 [47], 1.8 [48], 1.5 [49], and 2.0 [45], respectively. Other authors in USA, Spain, Taiwan, and Israel also found high M/F ratios, 1.4 [50], 1.5 [25], 1.6 [51], and 1.5 [52], respectively.…”

Section: Discussionmentioning

confidence: 99%

“…In all four regions (northern coast, central coast, southern highlands, and jungle) subgroup C predominated, subgroup B was the second most common, and subgroup E was the least common (except for the central coast where B and E were identified in the same number). Likewise, the bordering country of Brazil [41], [56], as well as the non-bordering Latin American countries of Mexico [57] and Cuba [45], also observed a predominance of subgroup C. On the other hand, two other countries bordering Peru, Colombia [38], [58] and Argentina [43], noted a predominance of subgroup B.…”

Section: Discussionmentioning

confidence: 99%

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Adenovirus Respiratory Tract Infections in Peru

Ampuero

Ocaña²,

Gómez

et al. 2012

PLoS ONE

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BackgroundCurrently, there is a paucity of data regarding human adenovirus (HAdv) circulation in Andean regions of South America. To address this shortcoming, we report the clinical, phylogenetic, and epidemiologic characteristics of HAdv respiratory tract infection from a large sentinel surveillance study conducted among adults and children in Peru.Methods/Principal FindingsOropharyngeal swabs were collected from participants visiting any of 38 participating health centers, and viral pathogens were identified by immunofluorescence assay in cell culture. In addition, molecular characterization was performed on 226 randomly selected HAdv samples. Between 2000 and 2010, a total of 26,375 participants with influenza-like illness (ILI) or severe acute respiratory infection (SARI) were enrolled in the study. HAdv infection was identified in 2.5% of cases and represented 6.2% of all viral pathogens. Co-infection with a heterologous virus was found in 15.5% of HAdv cases. HAdv infection was largely confined to children under the age of 15, representing 88.6% of HAdv cases identified. No clinical characteristics were found to significantly distinguish HAdv infection from other respiratory viruses. Geographically, HAdv infections were more common in sites from the arid coastal regions than in the jungle or highland regions. Co-circulation of subgroups B and C was observed each year between 2006 and 2010, but no clear seasonal patterns of transmission were detected.Conclusions/SignificanceHAdv accounted for a significant fraction of those presenting with ILI and SARI in Peru and tended to affect the younger population disproportionately. Longitudinal studies will help better characterize the clinical course of patients with HAdv in Peru, as well as determine the role of co-infections in the evolution of illness.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Adenovirus Respiratory Tract Infections in Peru

Ampuero

Ocaña²,

Gómez

et al. 2012

PLoS ONE

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“…Se identificaron adenovirus en 5,9 % de los menores de 5 años con IRA en Bucaramanga en ambas estaciones, cercano a la prevalencia reportada en hospitales centinela de Bogotá y Manizales entre 1997-2003, donde se presentó de manera constante durante todos los meses del año, con un aumento en marzo, julio, octubre y diciembre (26).…”

Section: Discussionunclassified

Etiología y estacionalidad de las infecciones respiratorias virales en menores de cinco años en Bucaramanga, Colombia

García-Corzo

Niederbacher-Velásquez

González

et al. 2017

iatreia

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Respiratory syncytial virus, adenoviruses, and mixed acute lower respiratory infections in children in a developing country

2015

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There is growing evidence suggesting greater severity and worse outcomes in children with mixed as compared to single respiratory virus infections. However, studies that assess the risk factors that may predispose a child to a mixture of respiratory syncytial virus (RSV) and adenoviral infections, are scarce. In a retrospective cohort study, the study investigated the epidemiology of RSV and adenovirus infections and predictors of mixed RSV-adenoviral infections in young children hospitalized with acute lower respiratory infection in Bogota, Colombia, South America, over a 2-year period 2009–2011. Of a total of 5,539 children admitted with a diagnosis of acute lower respiratory infection, 2,267 (40.9%) who were positive for RSV and/or adenovirus were selected. Out the total number of cases, 1,416 (62.5%) infections occurred during the 3-month period from March to May, the first rainy season of Bogota, Colombia. After controlling for gender, month when the nasopharyngeal sample was taken, and other pre-existing conditions, it was found that an age greater than 6 months (OR:1.74; CI 95%:1.05–2.89; P = 0.030) and malnutrition as a comorbidity (OR:9.92; CI 95%:1.01–100.9; P = 0.049) were independent predictors of mixed RSV-adenoviral infections in the sample of patients. In conclusion, RSV and adenovirus are significant causes of acute lower respiratory infection in infants and young children in Bogota, Colombia, especially during the first rainy season. The identified predictors of mixed RSV-adenoviral infections should be taken into account when planning intervention, in order to reduce the burden of acute lower respiratory infection in young children living in the country.

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Adenovirus en Niños Menores de Cinco Años. Patrones de Circulación, Características Clínicas y Epidemiológicas en Colombia, 1997-2003

Abstract: The data suggested that respiratory infection due to adenovirus was a low frequency event amongst the children seeking medical care at the sentinel hospitals. However, when respiratory disease was caused by adenovirus, it was severe.

Cited by 16 publications

References 13 publications

Adenovirus Respiratory Tract Infections in Peru

Adenovirus Respiratory Tract Infections in Peru

Etiología y estacionalidad de las infecciones respiratorias virales en menores de cinco años en Bucaramanga, Colombia

Respiratory syncytial virus, adenoviruses, and mixed acute lower respiratory infections in children in a developing country

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