Adenovirus infection and disease in recipients of hematopoietic cell transplantation

Garnes, Natalie J. M. Dailey; Ragoonanan, Dristhi; Aboulhosn, Aya

doi:10.1097/qco.0000000000000605

Cited by 16 publications

(35 citation statements)

References 82 publications

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“…Nephrotoxicity from cidofovir is an important concern and can be worsened with the concomitant administration of some common antimicrobial and immunosuppressive medications. 26 We noted a higher incidence of renal dysfunction and CRRT utilization in the cohort of cases receiving cidofovir.…”

Section: Discussionmentioning

confidence: 67%

“…24,25 There is currently no approved antiviral treatment for adenovirus in North America or Europe though cidofovir is routinely used as a preemptive therapy in HSCT patients and we noted widespread use among our immunocompromised cases. 26 It was notable that 25% of immunocompetent cases received cidofovir despite a relatively low rate of adenoviremia in this group. Nephrotoxicity from cidofovir is an important concern and can be worsened with the concomitant administration of some common antimicrobial and immunosuppressive medications.…”

Section: Discussionmentioning

confidence: 79%

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Adenoviral Respiratory Infection-Associated Mortality in Children: A Retrospective Case Series

Spaeder

Stewart

Sharron

et al. 2020

J Pediatr Intensive Care

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Viral respiratory infections are a leading cause of illness and hospitalization in young children worldwide. Case fatality rates in pediatric patients with adenoviral lower respiratory tract infection requiring intensive care unit (ICU) admission have been reported between 7 and 22%. We investigated the demographics and clinical characteristics in pediatric mortalities associated with adenoviral respiratory infection at 12 academic children's hospitals in the United States. There were 107 mortality cases included in our study, 73% of which had a chronic medical condition. The most common chronic medical condition was immunocompromised state in 37 cases (35%). The incidences of pediatric acute respiratory distress syndrome (78%) and multiple organ dysfunction syndrome (94%) were profound. Immunocompetent cases were more likely to receive mechanical ventilation within the first hour of ICU admission (60 vs. 14%, p < 0.001) and extracorporeal membrane oxygenation (27 vs. 5%, p = 0.009), and less likely to receive continuous renal replacement therapy (20 vs. 49%, p = 0.002) or have renal dysfunction (54 vs. 78%, p = 0.014) as compared with immunocompromised cases. Immunocompromised cases were more likely to have bacteremia (57 vs. 16%, p < 0.001) and adenoviremia (51 vs. 17%, p < 0.001) and be treated with antiviral medications (81 vs. 26%, p < 0.001). We observed a high burden of nonrespiratory organ system dysfunction in a cohort of pediatric case fatalities with adenoviral respiratory infection. The majority of cases had a chronic medical condition associated with an increased risk of complications from viral respiratory illness, most notably immunocompromised state. Important treatment differences were noted between immunocompromised and immunocompetent cases.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 79%

Adenoviral Respiratory Infection-Associated Mortality in Children: A Retrospective Case Series

Spaeder

Stewart

Sharron

et al. 2020

J Pediatr Intensive Care

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“…Although these exogenous “off the shelf” cells remain experimental, they show promise and are currently in phase III clinical trials. 9,80…”

Section: Treatmentmentioning

confidence: 99%

Adenovirus Infection and Transplantation

2021

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Adenoviruses result in a wide array of clinical presentations, including primarily respiratory, gastrointestinal, genitourinary, or systemic infections. Although adenovirus causes mild disease limited to a single organ system in immunocompetent individuals, severe and life-threatening infections do rarely occur. Disseminated disease and severe localized disease resulting in significant morbidity and mortality have been well described in the immunocompromised populations. Although asymptomatic viremia, respiratory tract, and gastrointestinal infections are the most common disease in most transplant patients, renal transplant patients more commonly experience urinary tract infections, including hemorrhagic cystitis or nephritis. Diagnosis requires astute clinical awareness of the patient's clinical presentation that would be compatible with adenovirus combined with cultures, molecular testing, polymerase chain reaction, and tissue sampling. There is no Food and Drug Administration-approved treatment for adenovirus; however, several studies have evaluated therapeutic options including cidofovir, brincidofovir, and immunotherapy. This article will summarize our current understanding of adenovirus in the transplant population.

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“…Considering that no anti-HAdV drugs are presently in clinical use, disinfectants are important for preventing outbreak of HAdV (1,10) and it is important to evaluate the virucidal effects of disinfectants on HAdVs.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…HAdV-B11 associated with hemorrhagic cystitis is a major concern in hematopoietic stem cell transplantation because it causes secondary infection due to the infection of the virus in the environment (6)(7)(8)(9). Post transplantation infection caused by adenovirus species B or C, is a problem worldwide (10)(11)(12)(13)(14)(15)(16). Adenoviruses associated with these infections are known to be explosively transmitted in confined spaces such as hospitals.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Anti-Adenoviral Activity of ALTANT, an Ozonated Alcohol Disinfectant

et al. 2020

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Seven species (A-G) of human mastadenovirus (HAdV) are known, and more than 100 types have been reported. HAdV is highly resistant to common hand sanitizers. Epidemic keratoconjunctivitis and pharyngoconjunctival fever caused by HAdV can be explosively transmitted in a confined space, resulting in outbreaks such as nosocomial infections.Given the absence of an antiviral agent for HAdV infection, it is important to prevent the spread of infection using disinfectants. The bactericidal and virucidal activities of ozone have already been known widely. ALTANT is an ozonated alcohol preparation developed by E-TECH Co., Ltd.

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Adenovirus infection and disease in recipients of hematopoietic cell transplantation

Cited by 16 publications

References 82 publications

Adenoviral Respiratory Infection-Associated Mortality in Children: A Retrospective Case Series

Adenoviral Respiratory Infection-Associated Mortality in Children: A Retrospective Case Series

Adenovirus Infection and Transplantation

Evaluation of the Anti-Adenoviral Activity of ALTANT, an Ozonated Alcohol Disinfectant

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