Adenovirus-mediated intralesional interferon-γ gene transfer induces tumor regressions in cutaneous lymphomas

Dummer, Reinhard; Hassel, Jessica C.; Fellenberg, Friederike; Eichmüller, Stefan B.; Maier, Tanja; Seksik, Philippe; Acres, Bruce; Bleuzen, Pascal; Bataille, Vincent; Squiban, Patrick; Burg, G.; Urosevic, Mirjana

doi:10.1182/blood-2004-01-0360

Cited by 97 publications

(69 citation statements)

References 31 publications

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“…However, RRMs can have a structural role in proteinprotein interactions independent of RNA binding (Fribourg et al 2003), so we cannot determine the molecular function of Swm and its homologs by genetic methods alone. We are intrigued by the fact that the other vertebrate homolog, RBM-26, was identified as se70-2, an autoantigen that is recognized by sera of cutaneous T-cell lymphoma patients and has been used as a diagnostic marker for this tumor (Eichmuller et al 2001;Dummer et al 2004). In addition, the mouse RBM-26/se70-2 locus was identified as one of four genes deleted in a region required for normal murine skeletal, cartilage, and craniofacial development (Peterson et al 2002).…”

Section: Discussionmentioning

confidence: 99%

A Screen for Modifiers of Hedgehog Signaling inDrosophila melanogasterIdentifiesswmandmts

et al. 2008

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Signaling by Hedgehog (Hh) proteins shapes most tissues and organs in both vertebrates and invertebrates, and its misregulation has been implicated in many human diseases. Although components of the signaling pathway have been identified, key aspects of the signaling mechanism and downstream targets remain to be elucidated. We performed an enhancer/suppressor screen in Drosophila to identify novel components of the pathway and identified 26 autosomal regions that modify a phenotypic readout of Hh signaling. Three of the regions include genes that contribute constituents to the pathway-patched, engrailed, and hh. One of the other regions includes the gene microtubule star (mts) that encodes a subunit of protein phosphatase 2A. We show that mts is necessary for full activation of Hh signaling. A second region includes the gene second mitotic wave missing (swm). swm is recessive lethal and is predicted to encode an evolutionarily conserved protein with RNA binding and Zn 1 finger domains. Characterization of newly isolated alleles indicates that swm is a negative regulator of Hh signaling and is essential for cell polarity.

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Section: Discussionmentioning

confidence: 99%

A Screen for Modifiers of Hedgehog Signaling inDrosophila melanogasterIdentifiesswmandmts

et al. 2008

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“…The use of recombinant cytokines has found its rationale in the immunobiology of this disease group and aims to enhance antitumor immunity (1,2). As an alternative to recombinant cytokines that are often associated with significant systemic side effects, we recently described adenovirusmediated (Ad-mediated) delivery of human IFN-γ gene directly into CL lesions, showing good tolerability together with promising efficacy (3). Adenoviral vectors belong to the most frequently used gene delivery systems due to their ability to transduce a broad spectrum of cells and package large sequences and their low production costs (4).…”

Section: Introductionmentioning

confidence: 99%

Type I IFN innate immune response to adenovirus-mediated IFN-γ gene transfer contributes to the regression of cutaneous lymphomas

Urosevic¹,

Fujii²,

Calmels³

et al. 2007

J. Clin. Invest.

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IntroductionPrimary cutaneous lymphomas (CLs) represent the second most common extranodal group of non-Hodgkin lymphomas and are characterized by an accumulation of clonal T or B lymphocytes preferentially homing to the skin (1). Most CLs are indolent diseases with good prognosis that display a chronic course, sometimes progressing over decades. This in turn creates an increasing need for treatment modalities that would effectively control the disease for a longer time period together with showing good tolerability. Immunotherapy is one such solution that currently belongs to the standard therapeutic armamentarium. The use of recombinant cytokines has found its rationale in the immunobiology of this disease group and aims to enhance antitumor immunity (1, 2). As an alternative to recombinant cytokines that are often associated with significant systemic side effects, we recently described adenovirusmediated (Ad-mediated) delivery of human IFN-γ gene directly into CL lesions, showing good tolerability together with promising efficacy (3). Adenoviral vectors belong to the most frequently used gene delivery systems due to their ability to transduce a broad spectrum of cells and package large sequences and their low production costs (4). The fact that they do not integrate into the host genome has made them attractive in cancer immunotherapy, where only

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“…[5][6][7][8][9][10][11][12][13][14][15][16] Much evidence supports that malignant T cells drive the immune dysregulation to impede antitumor immunity and that suppression of the patient's cellular immunity is associated with increased disease activity. [17][18][19][20][21][22] Two factors that seem to hold a central position in driving the immune dysregulation are signal transducer and activator of transcription 3 (Stat3) and the immunoregulatory cytokine interleukin-10 (IL-10). In keeping, the malignant activity of Stat3 and the expression of IL-10 increase during disease progression in parallel with the evolving immune dysregulation.…”

Section: Introductionmentioning

confidence: 99%

Staphylococcal enterotoxins stimulate lymphoma-associated immune dysregulation

Krejsgaard

Willerslev-Olsen

Lindahl

et al. 2014

Blood

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Adenovirus-mediated intralesional interferon-γ gene transfer induces tumor regressions in cutaneous lymphomas

Cited by 97 publications

References 31 publications

A Screen for Modifiers of Hedgehog Signaling inDrosophila melanogasterIdentifiesswmandmts

A Screen for Modifiers of Hedgehog Signaling inDrosophila melanogasterIdentifiesswmandmts

Type I IFN innate immune response to adenovirus-mediated IFN-γ gene transfer contributes to the regression of cutaneous lymphomas

Staphylococcal enterotoxins stimulate lymphoma-associated immune dysregulation

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