2014
DOI: 10.2169/internalmedicine.53.1192
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Adenovirus Pneumonia Presenting with Nodular Shadows on Chest X-ray in Two Unrelated Allogeneic Bone Marrow Transplant Recipients

Abstract: Adenoviruses are increasingly recognized as important pathogens following allogeneic stem cell transplantation. We herein report two cases of disseminated adenovirus infection that presented with nodular shadows on chest X-ray after allogeneic bone marrow transplantation from unrelated donors. Both patients died of respiratory failure. Autopsies revealed adenovirus infection of multiple organs. Adenovirus infection should be suspected when nodular lung lesions of unknown origin appear in allogeneic stem cell t… Show more

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Cited by 4 publications
(2 citation statements)
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“…Moreover, 2 patients who died from severe pneumonitis and ARDS with a positive adenovirus PCR test did not have another apparent cause of respiratory illness. It was described that disseminated adenovirus infection can cause pulmonary consolidation, such as bacterial pneumonia [17,18]. Because of similar clinical and radiographic findings, adenovirus infection may be under-recognized as a cause of fatal pneumonia in immunocompromised patients with severe lymphopenia or lymphocyte dysfunction.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, 2 patients who died from severe pneumonitis and ARDS with a positive adenovirus PCR test did not have another apparent cause of respiratory illness. It was described that disseminated adenovirus infection can cause pulmonary consolidation, such as bacterial pneumonia [17,18]. Because of similar clinical and radiographic findings, adenovirus infection may be under-recognized as a cause of fatal pneumonia in immunocompromised patients with severe lymphopenia or lymphocyte dysfunction.…”
Section: Discussionmentioning
confidence: 99%
“…Ganciclovir, commonly used to treat CMV infections, has been suggested a possible treatment for HAdV infections [35]; however, there are currently no official recommendations. In our review, three patients received ganciclovir for the treatment of co-infections or as a prophylaxis against CMV infections [12,28], and one patient received the drug for the treatment of an HAdV infection [7]. Brincidofovir, an experimental oral lipid ester of cidofovir with less nephrotoxicity, is being tested as a possible treatment for HAdV infections (ClinicalTrials.gov Identifier: NCT02087306) [36] and has shown a favorable safety and tolerability profile in a recent study [37].…”
Section: Discussionmentioning
confidence: 99%