Adenovirus Respiratory Infections Post Pandemic in Colombia: An Old Enemy With Increased Severity in Pediatric Population?

Gutiérrez-Tobar, Iván Felipe; Beltrán-Arroyave, Claudia Patricia; Díaz, Alejandro A.; Londoño, Juan Pablo; Jimenez, Karen L; Zamora, Carmen G; Camacho-Moreno, Germán; Álvarez-Olmos, Martha I.; Beltrán-Higuera, Sandra Jaqueline; Álvarez-Moreno, Carlos

doi:10.1097/inf.0000000000003827

Cited by 5 publications

(8 citation statements)

References 3 publications

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“…Previous studies have shown that 31 % of patients with adenovirus pneumonia can be complicated by PE, this being much more frequent in patients with a severe presentation (up to 79 %) [10]. This study was carried out during a peak of severe adenoviral infections in Colombia [8]. We detected adenovirus in 41 % of the samples, of which in almost half no related bacterial pathogen was documented.…”

Section: Discussionmentioning

confidence: 83%

“…In Colombia, recent reports have documented an increase in complications related to Streptococcus pneumoniae pneumonia due to serotype replacement [7] and circulation of more aggressive adenoviruses in children (including more pleural effusion cases) [8]. According to the literature, Pneumococcus has been reported more frequently in samples sent for PCR than in samples sent for culture [2, 9].…”

Section: Introductionmentioning

confidence: 99%

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Use of multiplex PCR in pleural effusion: is it necessary to change the paradigm of culture-based methods?

Londono-Ruiz,

Vargas-Garcia,

Cardenas-Muller

et al. 2023

Access Microbiology

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The microbiological diagnosis of pleural effusion is based largely on classical microbiology methods, but these methods have a high rate of false negative results. Some previous studies have shown improved diagnostic performance for pathogens such as Streptococcus pneumoniae using molecular biology methods. We present the use of a multiplex PCR platform (BIOFIRE FILMARRAY Pneumonia Panel) for the aetiological diagnosis of pleural effusion in paediatric pneumonia. We present a case series of 17 pleural fluid samples that were processed by culture-based microbiology and molecular biology methods. Microbiological isolation was successful in four cases (25 %) through traditional culture methods. In contrast, the molecular biology panels allowed for detection in 16 out of 17 cases (94 %). The results from these panels led to a change in management for nine out of the 17 cases (52 %). This study found an increase in aetiological diagnosis in complicated pneumonia in children by using molecular biology methods, which led to a significant change in patient management.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Use of multiplex PCR in pleural effusion: is it necessary to change the paradigm of culture-based methods?

Londono-Ruiz,

Vargas-Garcia,

Cardenas-Muller

et al. 2023

Access Microbiology

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“…Between 1997 and 2003, adenovirus was found in 2.6% of the analyzed samples; between 2009 and 2011, it was detected in 7.5% of samples from patients with lower respiratory tract disease (4). In hospitalized children with community-acquired pneumonia, adenovirus is responsible for more than 10% of the cases, and in 2022, it was the fourth most common respiratory virus in Colombia, with an isolation rate of 16.9% (1).…”

Section: Discussionmentioning

confidence: 99%

“…Most cases occur in children under five years of age and are usually self-limited or mild. However, more aggressive outbreaks have been described, generally associated with serotypes 3 and 7 1 . In Colombia and worldwide, the risk of common respiratory infections decreased temporarily due to the non-pharmacological place-preventive strategies during COVID-19.…”

mentioning

confidence: 99%

Brote de adenovirus grave en Colombia: experiencia de un hospital pediátrico de tercer nivel en 2022

Vélez-Tirado,

Castaño-Jaramillo,

Restrepo-Gualteros

et al. 2024

biomedica

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Introduction. During the SARS-CoV-2 pandemic, many countries experienced decreased respiratory virus circulation, followed by an out-of-season outbreak. In a pediatric hospital in Colombia, we observed a surge in severe adenovirus infections, leading to concerns about the impact of eased public health restrictions and immune debt in children under five years old.Objective. To describe the clinical characteristics of patients with severe adenovirus infection in a pediatric hospital in Colombia.Materials and methods. We reviewed the data of 227 patients with severe adenovirus infection at the Fundación Hospital Pediátrico La Misericordia.Results. A total of 196 patients were included in this study. The median age was two years, and 62% were male. Adenoviruses were isolated from all patients’ samples. Ninetyseven percent were admitted to the pediatric intensive care unit, 94% required respiratory support, and the in-hospital lethality rate was 11%.Conclusion. In 2022, there was an outbreak of severe adenovirus infections, affecting mainly children under five years of age, with higher-than-usual mortality.

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“…El virus sincitial respiratorio (VSR), virus de la influenza, rinovirus, parainfluenza, adenovirus y enterovirus son las principales causas de infecciones respiratorias en pacientes pediátricos que requieren hospitalización. 4 Como hemos venido comentando, se han observado múltiples variaciones en cuanto a la circulación de los diferentes virus, al inicio de la pandemia www.medigraphic.org.mx desde el punto de atención médica, el volumen de visitas a urgencias así como los ingresos hospitalarios asociados a infecciones por virus respiratorios distintos a SARS-CoV-2 disminuyeron de manera importante posterior a la implementación de medidas no farmacológicas, incluidas las exacerbaciones asmáticas. 1 Varios países, incluido Estados Unidos, han emitido recientemente alertas de salud debido a un aumento en la frecuencia y gravedad de las infecciones por VSR e influenza.…”

Section: Abreviaturasunclassified

El regreso de los virus respiratorios

Arias de la Garza,

Vargas García

2023

Revista Latinoamericana De Infectología Pediátrica

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Adenovirus Respiratory Infections Post Pandemic in Colombia: An Old Enemy With Increased Severity in Pediatric Population?

Cited by 5 publications

References 3 publications

Use of multiplex PCR in pleural effusion: is it necessary to change the paradigm of culture-based methods?

Use of multiplex PCR in pleural effusion: is it necessary to change the paradigm of culture-based methods?

Brote de adenovirus grave en Colombia: experiencia de un hospital pediátrico de tercer nivel en 2022

El regreso de los virus respiratorios

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