Adenoviruses

Foy, Hjordis M.; Grayston, J. T.

doi:10.1007/978-1-4613-3237-4_3

Cited by 4 publications

(3 citation statements)

References 79 publications

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“…This study was expected to be an investigation of the primary antibody response to vaccination because prior serological surveys suggested that few recruits would have been exposed to adenoviruses 4 and 7 prior to basic training (Foy & Grayston, 1982). The nature of the study changed when detectable antibodies to adenovirus 7 were found two days after inoculation in nearly all participants (91.7%), and IgG antibodies to adenovirus 4 were found at that time in more than half of the participants (58.3%).…”

Section: Discussionmentioning

confidence: 99%

“…It is not clear why the proportion of recruits with antibodies was so much higher than expected, but it may be that the viruses in question are becoming more widespread in the population at large. In some populations, such as Taiwan and Japan, the probability of past exposure in adults was much higher than in the United States in the 1960s (Foy & Grayston, 1982). Increased international travel and other factors may have produced wider dissemination of these viruses in the United States than was the case when the prevalence estimates for these viruses that guided the study design were determined.…”

Section: Discussionmentioning

confidence: 99%

“…The adenovirus inoculations that provided the challenge to the immune system are given routinely to all recruits the day of arrival at basic training. Previous serological surveys have indicated that most recruits could be expected to have had no prior exposure to these viruses prior to arrival at basic training (Foy & Grayston, 1982). These findings gave reason to believe that it would be possible to examine the primary antibody response to these inoculations.…”

Section: Introductionmentioning

confidence: 99%

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Neuroticism and antibody responses in military recruits.

Vickers¹,

Hervig²,

Rappaport³

et al. 1991

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Problem Research with animals suggests that inoculations given to protect against viruses may be ineffective when given during periods of high stress because stress-related down-regulation of the immune system impairs the immune response to vaccination. Objective This study was undertaken to quantify the effects of stress on antibody production in U.S. Navy recruits. The estimates were developed by comparing the antibody production of stresssusceptible recruits to that of stress-resistant recruits following routine inoculations during the challenging initial phases of training. Approach The 12 highest and 12 lowest scorers on a measure of emotionality and stresssusceptibility were selected from a larger sample. The neutralizing antibody responses to inoculations for adenovirsuses 4 and 7 given the day of arrival at the Recruit Training Command, San Diego, were determined two days after inoculation, then 23-25 days later, then again another 24-27 days later. Results Most recruits had detectable antibody levels two days after inoculation (91.8% for adenovirus 7; 58.4% for adenvirus 4). Among recruits with detectable antibodies two days after inoculation, stress-susceptible recruits had lower antibodies than stress-resistant recruits for both adenoviruses at the time of the first antibody measurement, but not for the two later measurements. Conclusions Antibody responses to booster shots may be sluggish in stress-susceptible individuals if given at a stressful time. This information suggests that it is desirable to allow sufficient time between inoculation and deployment to permit even stress-susceptible individuals to respond to booster shots given as part of preparations for deployment or other instances of potential exposures to important viruses. Additional studies to define the precise time course of antibody responses and determine whether the results generalize to initial inoculations and to other viral and bacterial pathogens would be useful for establishing vaccination policies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neuroticism and antibody responses in military recruits.

Vickers¹,

Hervig²,

Rappaport³

et al. 1991

PsycEXTRA Dataset

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Antigenic homogeneity of adenovirus types 1, 2, 5, and 6

Kaier

Wigand

1986

Journal of Medical Virology

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One hundred twenty strains of adenovirus types 1, 2, 5, and 6 (subgenus C), isolated at various times and places, were tested by neutralization and hemagglutination inhibition with two antisera of each type. Except for one type 5 strain they reacted largely type-specifically in both tests and neither qualitative nor quantitative differences were observed. Serologically intermediate strains were not found. The antigenic homogeneity is in contrast to the heterogeneity of the genomes of subgenus C adenoviruses.

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Evaluation of four methods for rapid detection of adenovirus

Trabelsi

Pozzetto

Mbida

et al. 1992

Eur. J. Clin. Microbiol. Infect. Dis.

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Four methods for rapid detection of adenovirus were evaluated by testing retrospectively 28 frozen clinical specimens from which an adenovirus strain had been isolated. After thawing all specimens were retested for the presence of adenovirus by conventional culture on KB cells and found to be positive. The four tests used for rapid detection of adenovirus were a 48-hour culture technique, and an immunoassay, a latex agglutination test and an immunofluorescence assay for direct detection of viral antigen using commercially available reagents. Of the 28 specimens all were positive in the 48-hour culture, 25 (89%) positive in the immunoassay and 10 (36%) positive in the latex agglutination test. Six of eight nasopharyngeal aspirate specimens were positive in the immunofluorescence assay. Twenty-five clinical specimens negative for adenovirus on conventional culture were also negative in the 48-hour culture technique. Overall, the rapid (48-hour) culture technique was 100% sensitive and 100% specific compared to conventional culture. The direct detection of viral antigen by immunoassay was less sensitive, however results were available within a few hours. Prospective comparative studies are warranted to determine whether these rapid techniques could replace conventional culture in the routine diagnosis of adenovirus infection.

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Adenoviruses

Cited by 4 publications

References 79 publications

Neuroticism and antibody responses in military recruits.

Neuroticism and antibody responses in military recruits.

Antigenic homogeneity of adenovirus types 1, 2, 5, and 6

Evaluation of four methods for rapid detection of adenovirus

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