"Adenoviruses": Group Name Proposed for New Respiratory-Tract Viruses

Enders, John F.; Bell, Joseph A.; Dingle, John H.; Francis, Thomas; Hilleman, Maurice R.; Huebner, Robert J.; Payne, A. M.-M.

doi:10.1126/science.124.3212.119

Cited by 163 publications

(33 citation statements)

References 16 publications

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“…Human adenovirus was isolated for the first time in 1953, when a spontaneous in vitro culture degeneration of some adenoidal tissues was observed [37]. Later, it was found that the etiologic agent responsible for this cytopathic effect was a virus, which was the reason for its being named "adenovirus" [101]. The various adenoviral serotypes can be found in distinct tissues, such as the upper respiratory tract, the conjunctiva, and the intestines.…”

Section: Adenoviral Vectorsmentioning

confidence: 99%

Gene Transfer Technology in Therapy: Current Applications and Future Goals

1999

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Gene therapy has attracted much interest since the first submissions of phase I clinical trials in the early 1990s, for the treatment of inherited genetic diseases. Preliminary results were very encouraging and prompted many investigators to submit protocols for phase I and phase II clinical trials for the treatment of inherited genetic diseases and cancer. The possible application of gene transfer technology to treat AIDS, cardiopathies, and neurologic diseases is under evaluation. Some viral vectors have already been used to deliver HIV-1 subunits to immunize volunteers who are participating in the AIDS vaccine programs in the USA. However, gene delivery systems still need to be optimized in order to achieve effective therapeutic interventions. The purpose of this review is to summarize the latest achievements in improving gene delivery systems, their current application in preclinical studies and in therapy, and the most pressing issues that must be addressed in the area of vector design.

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Section: Adenoviral Vectorsmentioning

confidence: 99%

Gene Transfer Technology in Therapy: Current Applications and Future Goals

1999

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“…The abundant structural component called hexon made the bulk of the protein shell which essentially acts as a coating protein. The penton base and the fiber control virion cell interaction that establishes the viral tropism (Enders et al, 1956;Glasgow et al, 2006;Walther and Stein, 2000). (Fig 3: Ad structure).…”

Section: Adenovirus Vector (Ad)mentioning

confidence: 99%

Features and properties of viral and non-viral gene delivery systems towards effective gene therapy

Shettima

Ibrahim

Abbas

2017

IJM

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Gene therapy has revolutionized the treatment of hereditary and genetic link disorders by consciously swapping, fixing, adding or deleting the genetic sequences responsible for the condition. The culprit cells are altered by inserting purposeful genes and incorporated into their genome for proper expression. Germ line therapy ensures the genotypic changes to be transferred to the next generation (offspring) while the somatic type adequately rest on corrective pedestals and as such not advantageous to the offspring. The earlier was constrained by technical difficulties as well as ethical consideration. The accomplishment of the therapeutic benefits of gene therapy requires a special ferry system "vectors". Vectors are designed to transfer the desired gene into its target cell without exposing it to some degrading enzymes, and must allow transcription to successfully take place. A model vector must not be immunogenic, it must not trigger high immune response detrimental to the patient and a specific tropism must be a pre-requisite. The choice of a vector should be based on safety, cost and availability as well as the accessibility of possible options. Mainly for viral carriers, host immune response trigger are the main concern. Viral vectors most frequently used in gene therapy include adenoviruses, retroviruses, poxviruses, adeno-associated viruses and herpes simplex viruses.

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“…Coxsackie A types [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] (40). Coxsackie B tvpes [1][2][3][4][5] (40).…”

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“…Until 1947, 60 viruses had been cataloged as producing illness in man (1) (2) in utilizing suckling mice for isolation of a pathogenic virus, other than poliovirus, from the stools of two upstate New York cases of suspected poliomyelitis opened the door to the identification, in the en¬ suing 10 years, of 19 Poliovirus types [1][2][3] (39). Coxsackie A types [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] (40).…”

mentioning

confidence: 99%