Adenylate Kinase Activity and Glutathione Concentration of Cerebrospinal Fluid in Different Neurological Disorders

Ronquist, Gunnar; Frithz, Göran

doi:10.1159/000115063

Cited by 29 publications

(18 citation statements)

References 3 publications

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“…As enzymes and other intracellular constituents of cerebral origin may be expected to appear in the cerebro spinal fluid (CSF) after ischemic injury of the brain [37,38], various investigations of CSF have been performed after CPR [35,36,[38][39][40][41][42][43][44], Edgren et al [20] demon strated the prognostic significance of CSF lactate and oth er biochemical parameters such as adenylate kinase activ ity which showed a good correlation between prediction and outcome at 24 h after CPR [20]. Karkela et al [35.…”

Section: Predictive Value Of Laboratory Parameters In Serum and Cerebmentioning

confidence: 99%

The Prognostication of Cerebral Hypoxia after Out-of-Hospital Cardiac Arrest in Adults

1997

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Early determination of outcome after out-of-hospital cardiopulmonary resuscitation is a common problem with great ethical, economic, social and legal consequences. Although there has been a fulminant development of emergency medicine during the last three decades, severe cerebral damage sometimes cannot be avoided. For neurological outcome prediction after cardiac arrest clinical neurological signs, electrophysiological examinations, neuroimaging tests, and laboratory parameters in serum and cerebrospinal fluid are used today, nevertheless, there still remains a considerable degree of uncertainty. However, although prognostic criteria which enable the clinician to stop treatment cannot be given at the present time, useful applications of early prognostication after cardiac arrest range from counseling of families, triage decisions, and do-not-resuscitate decisions to future clinical investigations of brain resuscitative measures.

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Section: Predictive Value Of Laboratory Parameters In Serum and Cerebmentioning

confidence: 99%

The Prognostication of Cerebral Hypoxia after Out-of-Hospital Cardiac Arrest in Adults

1997

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“…Sampling and handling of the CSF material, as well as the analytical procedure, have been described elsewhere. 11 Normal values are below 0.015 U/l (the lower limit of detection). As significant amounts of blood may contribute to the total adenylate kinase activity," 2 samples with blood contamination were discarded.…”

Section: Computed Tomographymentioning

confidence: 99%

“…Adenylate kinase is a predominantly cytoplasmic enzyme normally not found in the CSF, but which appears under conditions known to be associated with even slight changes of plasma membrane function. 11 Glutathione is an intracellular tripeptide found in the CSF in patients with major neurological signs.…”

mentioning

confidence: 99%

Ischemic edema in stroke. A parallel study with computed tomography and cerebrospinal fluid markers of disturbed brain cell metabolism.

Terént¹,

Ronquist²,

Bergström³

et al. 1981

Stroke

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SUMMARY Thirteen patients with stroke and one with TIA had repeated examinations with computed tomography (CT) of the head, examination of the cerebrospinal fluid (CSF) for adenylate kinase, glutathione, lactate, and albumin and clinical evaluations during the flrst fortnight after onset. In 9 patients with cerebral infarction edema shown on the CT scans was maximal on days 2-5, after which it diminished. In 2 patients with intracerebral hemorrhage the edema appeared early as a zone of low-attenuation around the highattenuation area. Most patients with large lesions deteriorated clinically during development of the edema. In 3 patients the CT scans were inconclusive, probably because the lesion was too small. Adenylate kinase activity was present in all CSF samples during the period 6 hours-S days, while glutathione was occasionally present in the CSF in 12 of the 14 patients. These findings are believed to indicate cell swelling and a leak in the plasma membrane. Based on these observations, it is suggested that initial ischemic edema is intracellular in patients with cerebral infarction, and that adenylate kinase in CSF is a sensitive marker for this type of edema.

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“…Although increased AK activity in the CSF of patients with neurological disease was reported [13][14][15]. further detailed study is necessary.…”

Section: Resultsmentioning

confidence: 95%

“…Further, Ronquist et al [12], and Ronquist and Frithz [13] reported that AK was consistently found in the CSF of patients with malignant brain tumors and cerebral infarction. However, Getaz et al [14] claimed that there was no clear correlation between the presence of disease in central nervous system (CNS) and enzyme activity.…”

Section: Resultsmentioning

confidence: 97%

Serum adenylate kinase activity and isoenzyme in acute cerebral vascular disease.

Endo

Iwata

Kuzuya

1989

J. Clin. Biochem. Nutr.

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SummarySerum adenylate kinase (AK) activity was measured in cerebral vascular diseases and the AK isoenzyme pattern was studied in the patients suffering from cerebral infarction, cerebral hemorrhage, myocardial infarction, and polymyositis. There was a significant difference in AK activity between the control subjects and patients with acute cerebral infarction. Serum AK activity showed a peak on the 2nd day to the 4th day after the stroke attack, maintained at high level for about one week, and decreased gradually thereafter. There were three isoenzymes (AK-1, AK-2, AK-3) of AK, and we found that the AK isoenzyme patterns were different in different disease. The AK isoenzyme patterns in patients with cerebral infarction and cerebral hemorrhage were different from those of control subjects. The AK-3 isoenzyme was dominant in the control subjects. The proportion of AK-1 isoenzyme was increased in cerebral infarction and cerebral hemorrhage compared with that for the control subjects, and the proportion of AK-2 isoenzyme was elevated in acute myocardial infarction and polymyositis. These results suggest that serum AK is a sensitive indicator of cerebral infarction and a useful marker to follow the course of patient recovery. Moreover, the analysis of AK isoenzymes is useful in the diagnosis of cerebral vascular diseases.Key Words: adenylate kinase, isoenzyme, cerebral vascular disease There are many reports concerning elevated creatine phosphokinase (CPK) activity and CPK isoenzymes in acute cerebral vascular diseases (CVD) [1][2][3]. Previously, we studied CPK activity and CPK isoenzymes in the early stage of cerebral infarction, and found that the CPK levels remained within the normal limit in many cases and the band of CPK-BB was not elevated. On the other hand,

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Adenylate Kinase Activity and Glutathione Concentration of Cerebrospinal Fluid in Different Neurological Disorders

Cited by 29 publications

References 3 publications

The Prognostication of Cerebral Hypoxia after Out-of-Hospital Cardiac Arrest in Adults

The Prognostication of Cerebral Hypoxia after Out-of-Hospital Cardiac Arrest in Adults

Ischemic edema in stroke. A parallel study with computed tomography and cerebrospinal fluid markers of disturbed brain cell metabolism.

Serum adenylate kinase activity and isoenzyme in acute cerebral vascular disease.

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