2001
DOI: 10.1074/jbc.m103923200
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Adenylyl Cyclase 3 Mediates Prostaglandin E2-induced Growth Inhibition in Arterial Smooth Muscle Cells

Abstract: Arterial smooth muscle cell (SMC) proliferation contributes to a number of vascular pathologies. Prostaglandin E 2 (PGE 2 ), produced by the endothelium and by SMCs themselves, acts as a potent SMC growth inhibitor. The growth-inhibitory effects of PGE 2 are mediated through activation of G-protein-coupled membrane receptors, activation of adenylyl cyclases (ACs), formation of cAMP, and subsequent inhibition of mitogenic signal transduction pathways in SMCs. Of the 10 different mammalian AC isoforms known toda… Show more

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Cited by 36 publications
(38 citation statements)
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“…9A) signal. Previous work with arterial smooth muscle established that although it expressed several AC isoforms, prostaglandin E 2 stimulated only AC-3 and that such stimulation was essential for inhibition of cell proliferation (27). This result highlights the likely importance of AC-3 in vascular smooth muscle, and its involvement in controlling a long-term response provides a satisfying link with our observation that transient Ca (100 nM, E, open bar).…”
Section: Ca 2ϩ Inhibition Of Adenylyl Cyclase 8941supporting
confidence: 68%
See 1 more Smart Citation
“…9A) signal. Previous work with arterial smooth muscle established that although it expressed several AC isoforms, prostaglandin E 2 stimulated only AC-3 and that such stimulation was essential for inhibition of cell proliferation (27). This result highlights the likely importance of AC-3 in vascular smooth muscle, and its involvement in controlling a long-term response provides a satisfying link with our observation that transient Ca (100 nM, E, open bar).…”
Section: Ca 2ϩ Inhibition Of Adenylyl Cyclase 8941supporting
confidence: 68%
“…In smooth muscle, such interactions are major determinants of both contractile activity and proliferation (27). Ca 2ϩ promotes contraction by stimulating phosphorylation of myosin light chain, whereas cGMP and cAMP, via their respective kinases, usually cause relaxation by either attenuating Ca 2ϩ signals or by more direct interactions with the contractile machinery (28 -31).…”
mentioning
confidence: 99%
“…1B). A short, possibly similar, Ac3 variant has previously been reported in male germ and smooth muscle cells (Gautier-Courteille et al, 1998;Wong et al, 2001). …”
Section: Expression Of Ac3 In the Olfactory Systemmentioning
confidence: 99%
“…Isolation and culture of murine SMCs. Normal murine SMCs were isolated from the thoracic aorta of male C57BL/6 mice via enzymatic digestion (13). Isolation of murine peritoneal macrophages.…”
Section: Methodsmentioning
confidence: 99%