Adept green synthesis of Cu2O nanoparticles using Kiwi fruit (Actinidia deliciosa) juice and Studies on their cytotoxic activity and antimicrobial evaluation

Kodasi, Barnabas; Kamble, Ravindra R.; Manjanna, J.; Hoolageri, Swati R.; Bheemayya, Lokesh; Nadoni, Vishwa B.; Bayannavar, Praveen K.; Dixit, Shruti; Vootla, Shyam Kumar; Kumbar, Vijay

doi:10.1016/j.jtemin.2022.100044

Cited by 9 publications

(4 citation statements)

References 44 publications

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“…Following administering 1 M NaOH (30 ml) in a drop wise manner led the mixture to change the color extemporaneously from green to bright orange precipitate indicating the generation of Cu 2 O NPs (Scheme 1). 50 The mixture was stirred overnight to allow for entire nucleation and subsequent growth of NPs. The orange precipitate was subsequently rinsed with Milli‐Q water after being centrifuged for 20 min at 5,000 rpm.…”

Section: Methodsmentioning

confidence: 99%

Dexterous green synthesis of Cu₂O nanoparticles: An amenable catalyst for aqueous click reaction, antiproliferative, and wound healing applications

Nayak,

Kamble,

Shettar

et al. 2023

Applied Organom Chemis

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The implementation of green chemistry principles to nanotechnology is one of the primary topics in the interdisciplinary area of nanoscience, which is a field of research that is perpetually expanding. A method for synthesizing Cu2O nanoparticles from copper(II) salts in an adroit and tactical way by employing solid jaggery as an economical and readily available source of reducing and stabilizing agent has been established. The explicitly synthesized nanoparticles were also discovered to be effective catalysts for the azide‐alkyne Huisgen cycloaddition (click reaction) in an aqueous media as green solvent. The substrate scope entails synthesis of 1,4‐disubstituted 1,2,3‐triazoles with good to excellent yields. The formation of Cu2O NPs was corroborated by various physicochemical methods like UV‐Visible (UV–Vis), Fourier Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS), Zeta potential, Field Emission Scanning Electron Microscopy (FESEM), energy dispersive X‐ray spectroscopy, and X‐ray diffraction analyses. The Cu2O NPs were substantiated by evaluation using HeLa, MCF‐7, and MDAMB‐231 (IC50: 72.66 μg ml−1, 47.31, 63.44 μg ml−1) cancer cell lines and unveiled eminent anticancer activities. This study also enabled us to elucidate the effects of Cu2O NPs on wound healing and cell migration.

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Section: Methodsmentioning

confidence: 99%

Dexterous green synthesis of Cu₂O nanoparticles: An amenable catalyst for aqueous click reaction, antiproliferative, and wound healing applications

Nayak,

Kamble,

Shettar

et al. 2023

Applied Organom Chemis

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“…The kiwi fruits (Actinidia deliciosa) were washed and cleaned and then skin and seeds was peeled off, fruit was cut into small pieces. The blender was used to make the fruit juice, and it was filtered through several layers of sterile gauze, then the juice was sterilized by Millipore filter 0.45 µm to get sterilized juice 100% (Kodasi et al, 2023). then from this solution the concentrations 25, 50 and 75% were prepared.…”

Section: -Kiwi Fruit (Actinidia Deliciosa)mentioning

confidence: 99%

Invitro Determination Effectiveness of Acacia senegal and Juice of Actinidia deliciosa with Estimate Synergistic Effect Towards Some Pathogenic Bacteria of Human

Nayyef,

Yaseen,

Wahab

2023

J. Res. Appl. Sci. Biotechnol.

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Antimicrobial resistance is a real threat to human health in worldwide. One of these medicinal plants that are commonly used in addition to its source as food is also used as a treatment for some cases. Gum Arabic (GA) consider it protection against various bacterial infections. Kiwi fruit Commonly known as the, Actinidia deliciosa valuable medicinal properties such as its anti-inflammatory, anti-bacterial and anti-asthmatic efficacy. Gum Arabic in different concentrations (10,20,30 and 50)% also Actinidia deliciosa in concentrations (25,50,75 and 100)% were used to determine the effect and inhibition activity against 4 species of bacteria were isolated from the different sites of the human body's infection included Urinary tract Infection (UTI) ,skin infections (pus), and from stool (diarrhea), these bacteria were (Staphylococcus aureus ,Salmonella sp. , Klebsiella pneumonia and E. coli) and compared with inhibitory effect of some antibiotic discs (Trimethoprim/Sulfamethaxazole (25 µg), Ciprofloxacin 10 µg, Vancomycin (30µg), Norfloxacin (10 µg), and Lincomycin (15µg). Salmonella sp. most affected by gum Arabic with an inhibition rate of 10, while with kiwi fruits the inhibition rate was 8 compared to the used antibiotics, which showed resistance to it. The Minimum Inhibitory concentration (MIC) of gum Arabic against all bacterial species was at 10%, while MIC of kiwi fruit solution was at 25%. Minimum Inhibitory Concentration (MIC) of gum Arabic against bacterial isolates was 10% and 25% of kiwi fruit.30% of gum Arabic showed highest inhibition activity toward Klebsiella pneumoniae and E. coli at 15 and 10 mm but 50% of it showed highest activity toward Salmonella sp and Staphylococcus aureus at 12 and 16mm, 75% and 100% of Kiwi fruit juice was more effective against Klebsiella pneumoniae and E. coli at same measure inhibition zone at 9mm but Salmonella sp and Staphylococcus aureus were more affected by 75% Kiwi fruit juice at 11 and 12 mm respectively compared with other concentrations. The synergism effect of Gum Arabic (10 µg/ml) with Trimethoprim (25 µg/ml) was more effected against E. coli, the inhibition zone was at 12mm and Staphylococcus aureus was at 30mm, E. coli was resistant to Gum Arabic (10 µg/ml) and Triethoprime (25µg/ml) each of one alone, but Staphylococcus aureus bacteria the inhibition zone was at 9mm when treated with Gum Arabic (10 µg/ml) and resistant to Triethoprime (25µg/ml). in the same time Klebsiella pneumoniae and Salmonella sp. not affected with this synergism and Triethoprime (25µg/ml) aone, but they affected with Gum Arabic Acacia Senegal (10 µg/ml), the inhibition zones were 11 and 10 mm respectively.

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“…There are also composite nanoparticles, such as lactoferrin-chitosan-gellan, which have been shown to have excellent antimicrobial capacity against S. aureus due to their higher zeta potential and smaller size [ 16 ]. Iron oxide nanoparticles (FeO NP) have also been reported to have good antibacterial activity, inhibiting the growth of gram-negative, gram-positive bacteria and microfungi [ 17 ]; cuprous oxide nanoparticles (Cu 2 O), with inhibitory potential against S. aureus , E. coli , A. niger , and C. albicans [ 18 ]; and titanium dioxide nanoparticles (TiO 2 NPs) that offer to be promising agents for the development of technologies to control infections caused by C. parapsilosis and Prototheca ciferrii [ 19 ]. In the case of ZnO NPs, antiviral effects have been demonstrated against SARS-CoV-2, Influenza A, Herpes virus, and cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Enhanced antimicrobial efficacy of biogenic ZnO nanoparticles through UV-B activation: A novel approach for textile garment

Asmat-Campos,

Rojas-Jaimes,

Simbrón de la Cruz

et al. 2024

Heliyon

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Adept green synthesis of Cu2O nanoparticles using Kiwi fruit (Actinidia deliciosa) juice and Studies on their cytotoxic activity and antimicrobial evaluation

Cited by 9 publications

References 44 publications

Dexterous green synthesis of Cu₂O nanoparticles: An amenable catalyst for aqueous click reaction, antiproliferative, and wound healing applications

Dexterous green synthesis of Cu₂O nanoparticles: An amenable catalyst for aqueous click reaction, antiproliferative, and wound healing applications

Invitro Determination Effectiveness of Acacia senegal and Juice of Actinidia deliciosa with Estimate Synergistic Effect Towards Some Pathogenic Bacteria of Human

Enhanced antimicrobial efficacy of biogenic ZnO nanoparticles through UV-B activation: A novel approach for textile garment

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Adept green synthesis of Cu2O nanoparticles using Kiwi fruit (Actinidia deliciosa) juice and Studies on their cytotoxic activity and antimicrobial evaluation

Cited by 9 publications

References 44 publications

Dexterous green synthesis of Cu2O nanoparticles: An amenable catalyst for aqueous click reaction, antiproliferative, and wound healing applications

Dexterous green synthesis of Cu2O nanoparticles: An amenable catalyst for aqueous click reaction, antiproliferative, and wound healing applications

Invitro Determination Effectiveness of Acacia senegal and Juice of Actinidia deliciosa with Estimate Synergistic Effect Towards Some Pathogenic Bacteria of Human

Enhanced antimicrobial efficacy of biogenic ZnO nanoparticles through UV-B activation: A novel approach for textile garment

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Product

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Dexterous green synthesis of Cu₂O nanoparticles: An amenable catalyst for aqueous click reaction, antiproliferative, and wound healing applications

Dexterous green synthesis of Cu₂O nanoparticles: An amenable catalyst for aqueous click reaction, antiproliferative, and wound healing applications